[1]张敬周,刘金豹,许 波,等.基于网络药理学探讨葛根桂枝牛膝汤治疗痛风性关节炎作用机制[J].陕西中医,2023,(4):519-523.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.026]
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基于网络药理学探讨葛根桂枝牛膝汤治疗痛风性关节炎作用机制
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年4期
页码:
519-523
栏目:
方药纵横
出版日期:
2023-04-05

文章信息/Info

作者:
张敬周1刘金豹12许 波12刘 源1李 刚12
(1.山东中医药大学,山东 济南 250014; 2.山东中医药大学附属医院,山东 济南 250014)
关键词:
痛风性关节炎 葛根桂枝牛膝汤 网络药理学 信号通路 靶点 活性成分
分类号:
R 684.3
DOI:
DOI:10.3969/j.issn.1000-7369.2023.04.026
文献标志码:
A
摘要:
目的:采用网络药理学方法探讨葛根桂枝牛膝汤治疗痛风性关节炎(GA)的作用机制。方法:采用TCMSP和TCMID数据库检索、筛选葛根桂枝牛膝汤的主要活性成分及对应靶标蛋白,与已知调控GA的蛋白靶标取交集作为候选预测靶标蛋白并绘制蛋白互作网络图。采用DAVID数据库对预测靶标进行GO功能分析以及KEGG通路富集分析。结果:葛根桂枝牛膝汤方中共有143个活性成分。葛根桂枝牛膝汤中的槲皮素、β-谷甾醇、7-O-甲基异琥珀酸醇、山柰酚、豆甾醇、美迪紫檀素、7-甲氧基-2-甲基异黄酮等成分可能通过IL-17信号通路、Th17细胞分化、TNF信号通路、VEGF信号通路、MAPK信号通路、坏死性凋亡通路等调控TNF、IL-6、VEGFA、IL-1β、EGFR等靶点治疗GA。结论:葛根桂枝牛膝汤可通过多组分、多靶点和多信号通路在GA的治疗中发挥抗炎和镇痛作用。

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备注/Memo

备注/Memo:
基金项目:山东省重点研发计划项目(2016GSF202022)
更新日期/Last Update: 2023-04-10