[1]王艳芬,马 琴,王 顺.肾康注射液联合穴位敷贴治疗慢性肾功能衰竭疗效及作用机制[J].陕西中医,2023,(5):595-599.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.012]
　WANG Yanfen,MA Qin,WANG Shun.Effects and mechanism of action of Shenkang injection combined with acupoint application on chronic renal failure[J].,2023,(5):595-599.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.012]
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肾康注射液联合穴位敷贴治疗慢性肾功能衰竭疗效及作用机制
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年5期
页码:
595-599
栏目:
临床研究
出版日期:
2023-05-05

文章信息/Info

Title:
Effects and mechanism of action of Shenkang injection combined with acupoint application on chronic renal failure
作者:
王艳芬; 马 琴; 王 顺
(新疆医科大学第一附属医院肾脏病中心,新疆 乌鲁木齐 830054)
Author(s):
WANG Yanfen; MA Qin; WANG Shun
(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
关键词:
慢性肾衰竭;  肾功能衰竭期;  肾康注射液;  穴位敷贴;  肾功能;  氧化应激
Keywords:
Chronic renal failure;  Renal failure;  Shenkang injection;  Acupoint application;  Renal function;  Oxidative stress
分类号:
R 692.5
DOI:
DOI:10.3969/j.issn.1000-7369.2023.05.012
文献标志码:
A
摘要:
目的:探讨肾康注射液联合穴位敷贴治疗慢性肾功能衰竭(CRF)的临床疗效及作用机制。方法:选取150例CRF患者,依据随机数字表法分为两组,各75例。对照组予肾康注射液治疗,治疗组予肾康注射液联合穴位敷贴治疗。比较两组总有效率、治疗前后症状体征积分、肾功能、氧化应激和肾纤维化指标。结果:治疗组总有效率92.00%高于对照组的74.67%(P<0.05)。治疗后两组症状体征有所缓解,且治疗组恶心呕吐、腰膝酸软、倦怠乏力、脘腹胀满、口渴不饮、食欲欠佳积分均低于对照组(P<0.05)。治疗后两组血肌酐(Scr)、血尿素氮(BUN)、血尿酸(UA)、活性氧(ROS)、丙二醛(MDA)、透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、半胱氨酸蛋白酶抑制蛋白C(Cys-C)均较治疗前降低,内生肌酐清除率(Ccr)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)较治疗前升高,且治疗组上述指标优于对照组(P<0.05)。治疗组总不良反应发生率为6.67%,与对照组的 14.67%比较差异无统计学意义(P>0.05)。结论:肾康注射液联合穴位敷贴治疗CRF疗效显著,可明显缓解患者临床症状,改善肾功能,其机制可能与该方能有效调节氧化应激、抑制肾纤维化进展有关。
Abstract:
Objective:To investigate the clinical efficacy and mechanism of action of Shenkang injection combined with acupoint application in the treatment of chronic renal failure(CRF).Methods:A total of 150 patients with CRF were selected and divided into two groups(75 patients each group)according to the random number table method.The control group was given Shenkang injection treatment,and the treatment group was added acupoint application treatment based on this.The total response rate,symptom sign scores before and after treatment,renal function,oxidative stress and renal fibrosis indexes were compared between the two groups.Results:The overall response rate of 92.00% in the treatment group was higher than that of 74.67% in the control group(P<0.05).The symptomatic signs of the two groups were alleviated after treatment,and the scores of nausea and vomiting,aching waist and knee,lassitude and fatigue,epigastric fullness,thirst and not drinking,and suboptimal appetite in the treatment group were lower than those in the control group(P<0.05).After treatment,serum creatinine(Scr),blood urea nitrogen(BUN),serum uric acid(UA),reactive oxygen species(ROS),malondialdehyde(MDA),hyaluronic acid(HA),type Ⅲ procollagen(PCⅢ),Cystain C(Cys-C)were decreased compared with before treatment in both groups,while endogenous creatinine clearance(Ccr),superoxide dismutase(SOD),and glutathione peroxidase(GSH-Px)were increased compared with before treatment,and the above indicators in the treatment group were better than those in the control group(P<0.05).The incidence of total adverse effects was 6.67% in the treatment group,which was not statistically different from 14.67% in the control group(P>0.05).Conclusion:Shenkang injection combined with acupoint application has a significant effect on CRF,which can significantly relieve the clinical symptoms of patients and improve renal function.Its mechanism may be related to the effective regulation of oxidative stress and inhibition of the progress of renal fibrosis.

参考文献/References:

[1] 陈如萍,刘 蕊,孙 遨,等.基于社区老年健康体检人群的慢性肾脏病流行病学调查[J].实用医学杂志,2021,37(13):1755-1760.
[2] 李永伟,李 慧,陈 婧,等.肾衰宁胶囊联合包醛氧淀粉治疗慢性肾功能衰竭患者的临床研究[J].中国临床药理学杂志,2020,36(21):3429-3432.
[3] 赵 亚,焦 剑,樊威伟.张大宁治疗慢性肾功能衰竭用药经验[J].中医杂志,2020,61(21):1867-1870.
[4] 何旭丽,徐军建.芪归益气活血汤治疗慢性肾衰竭气虚血瘀证疗效及对患者肾血流的影响[J].陕西中医,2021,42(1):51-53,60.
[5] 杨可新,张法荣.基于脑-肠轴探讨黑地黄丸治疗慢性肾衰竭脾虚证候的作用机制[J].中华中医药学刊,2020,38(5):92-96.
[6] 马 骥.实用内科学[M].12版.北京:人民卫生出版社,2005:2078-2094.
[7] 国家食品药品监督管理局.中药新药临床研究指导原则(试行)[S].北京:中国医药科学技术出版社,2002:163-164.
[8] 中华医学会.临床诊疗指南肾脏病学分册[M].北京:人民卫生出版社,2011:218-226.
[9] 王元真,陈兴强,赵汉儒.丹参多酚酸盐、前列地尔、谷胱甘肽三联疗法治疗慢性肾功能衰竭疗效及对患者eGFR水平的影响[J].陕西医学杂志,2018,47(10):1343-1345.
[10] 傅 奕,李 鑫,朱 莹,等.慢性肾功能衰竭用药规律及潜在机制分析[J].中国实验方剂学杂志,2022,28(6):151-158.
[11] 韩亚男,杨 文,高 乐,等.六味地黄丸合二至丸联合氯沙坦对老年慢性肾功能衰竭患者血液流变学及MCP-1、TGF-β1的影响[J].陕西中医,2021,42(12):1721-1723.
[12] 陈香美,李 平,孙雪峰,等.肾康制剂(肾康注射液、肾康栓)治疗慢性肾脏病合理应用专家共识[J].中国中西医结合杂志,2019,39(7):784-786.
[13] 莫嘉浩,綦向军,许洪彬,等.中药注射液治疗慢性肾功能不全的贝叶斯网状Meta分析[J].中国中药杂志,2021,46(2):454-466.
[14] 高 珊.穴位贴敷疗法配合中药复方治疗高血压肾病(CKD3-4期)的临床观察[D].沈阳:辽宁中医药大学,2018.
[15] Sun L,Xu H,Wang Y,et al.The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure[J].Aging(Albany NY),2020,12(18):18238-18250.
[16] 郑 玲,陈 立,库宝庆,等.新加肾元汤联合一体化治疗对慢性肾功能衰竭失代偿期患者的临床疗效[J].中成药,2021,43(4):1111-1113.
[17] 赵 亚,张勉之,樊威伟,等.国医大师张大宁治疗慢性肾功能衰竭微炎症状态经验[J].中华中医药杂志,2021,36(9):5278-5280.
[18] 强家维,靳贺超,梁胜然,等.益气活血通络方对糖尿病肾病大鼠肾组织RAGE/NOX4/ROS信号通路及氧化应激的影响[J].暨南大学学报:自然科学与医学版,2022,43(3):244-255.
[19] 董 俊,杨 莉,杨 蓓,等.前列地尔联合硫辛酸对糖尿病足患者纤维酶活性、抗氧化酶活性、血流动力学及血清炎症细胞因子的影响[J].中国老年学杂志,2022,42(3):550-553.
[20] 刘 瑶,李 伟.基于miRNA测序技术探讨黄芪-丹参药对干预自发性高血压大鼠肾损害的机制研究[J].中草药,2021,52(18):5599-5607.
[21] 杨 晖,邹 会,鲍燕芳,等.清热养阴化湿浊健脾活血法治疗慢性肾衰4～5期的临床效果及部分机制探讨[J].中华中医药学刊,2021,39(9):181-184.
[22] 许 丁,刘俊瑾,常壮鹏,等.黄芪甲苷对阿德福韦酯致肾损伤的保护作用和机制研究[J].中国医院药学杂志,2021,41(9):893-899.
[23] 周珊珊,艾中柱,李伟男,等.大黄抗肾脏纤维化的网络药理学及其活性成分的作用机制[J].中国实验方剂学杂志,2020,26(10):163-172.
[24] 陈莎莎,李 均.丹参酮ⅡA抗肾间质纤维化作用机制的研究进展[J].山东医药,2019,59(14):109-111.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81950132)
更新日期/Last Update: 2023-05-09