[1]廖 敏,谭 洁,吉 滔,等.补肾健骨汤对绝经后骨质疏松症患者骨代谢指标及性激素水平影响研究[J].陕西中医,2023,(6):726-729.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.009]
　LIAO Min,TAN Jie,JI Tao,et al.Effect of Bushen Jiangu decoction on bone metabolic indexes and sex hormone levels in postmenopausal osteoporosis patients[J].,2023,(6):726-729.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.009]
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补肾健骨汤对绝经后骨质疏松症患者骨代谢指标及性激素水平影响研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年6期
页码:
726-729
栏目:
临床研究
出版日期:
2023-06-05

文章信息/Info

Title:
Effect of Bushen Jiangu decoction on bone metabolic indexes and sex hormone levels in postmenopausal osteoporosis patients
作者:
廖 敏1; 2; 谭 洁1; 吉 滔2; 谢菊英1; 3
(1.湖南中医药大学,湖南 长沙 410208; 2.宁乡市人民医院,湖南 宁乡 410600; 3.湘南学院附属医院,湖南 郴州 423000)
Author(s):
LIAO Min; TAN Jie; JI Tao; XIE Juying
(Hunan University of Traditional Chinese Medicine,Changsha 410208,China)
关键词:
绝经后骨质疏松症;  补肾健骨汤;  骨代谢指标;  性激素水平;  骨密度
Keywords:
Postmenopausal osteoporosis;  Bushen Jiangu decoction;  Bone Metabolism Index;  Sex hormone level;  Bone density
分类号:
R 681
DOI:
DOI:10.3969/j.issn.1000-7369.2023.06.009
文献标志码:
A
摘要:
目的:探讨补肾健骨汤对绝经后骨质疏松症(PMOP)患者骨代谢指标及性激素水平的影响。方法:选取100例PMOP患者为研究对象,随机分为观察组和对照组,两组均为50例。对照组给予常规治疗,观察组在对照组基础上加用自拟补肾健骨汤治疗。比较两组患者治疗前后骨代谢指标[骨钙素(OC)、碱性磷酸酶(BAP)、骨保护素(OPG)]、不同部位骨密度(腰椎、全髋、股骨颈)、性激素[雌二醇(E2)、促卵泡激素(FSH)、黄体生成素(LH)]水平、细胞因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、胰岛素样生长因子(IGF-1)]以及数字疼痛评分(NRS)、Oswestry功能障碍指数(ODI)。结果:治疗后两组OC、BAP、OPG水平均高于治疗前(P<0.05),且观察组OC、BAP、OPG水平高于对照组(P<0.05); 治疗后两组腰椎、全髋、股骨颈部位骨密度均高于治疗前(P<0.05),且观察组腰椎、全髋、股骨颈部位骨密度高于对照组(P<0.05); 治疗后两组E2水平高于治疗前,LH、FSH水平低于治疗前(P<0.05),且观察组E2水平高于对照组,LH、FSH水平低于对照组(P<0.05); 治疗后两组IL-6、TNF-α低于治疗前,IGF-1高于治疗前(P<0.05),且观察组IL-6、TNT-α低于对照组,IGF-1高于对照组(P<0.05); 治疗后两组NRS评分、ODI均低于治疗前(P<0.05),且观察组NRS评分以及ODI低于对照组(P<0.05)。结论:补肾健骨汤可有效调节骨代谢指标、性激素水平与细胞因子水平,增强骨密度,改善骨质疏松症状。
Abstract:
Objective:To investigate the effect of Bushen Jiangu decoction on bone metabolism and sex hormone levels in postmenopausal osteoporosis(PMOP)patients.Methods:100 patients with PMOP were selected as study objects and randomly divided into observation group and control group,with 50 cases in both groups.The control group was treated with routine treatment,and the observation group was treated with Bushen Jiangu decoction on the basis of control group.Compared the bone metabolism indexes [osteocalcin(OC),alkaline phosphatase(BAP),osteoptetin(OPG)],bone mineral density in different parts(lumbar spine,total hip,femoral neck),sex hormones [estradiol(E2),follicle stimulating hormone(FSH),luteinizing hormone(LH)],cytokines [interleukin-6(IL-6)] and tumor necrosis factor-α(TNF-α)、 Insulin like growth factor-1(IGF-1), Digital Pain Score(NRS), and Oswellian Dysfunction Index(ODI)between two groups before and after treatment.Results:The levels of OC,BAP and OPG in the two groups after treatment were higher than those before treatment(P<0.05),and the levels of OC,BAP and OPG in the observation group were higher than those in the control group(P<0.05).After treatment,the BMD of lumbar,total hip and femoral neck in the two groups were higher than that before treatment(P<0.05),and the BMD of lumbar,total hip and femoral neck in the observation group were higher than that in the control group(P<0.05).After treatment,the E2 level in the two groups was higher than that before treatment,and the LH and FSH levels were lower than that before treatment(P<0.05).The E2 level in the observation group was higher than that in the control group,and the LH and FSH levels were lower than that in the control group(P<0.05); IL-6 and TNF-α in two groups after treatment were lower than that before treatment and IGF-1 was higher than that before treatment(P<0.05),and IL-6 and TNF-α in the observation group were lower than those in the control group,and IGF-1 was higher than that in the control group(P<0.05).After treatment,the NRS score and ODI of the two groups were lower than those before treatment(P<0.05),and the NRS score and ODI of the observation group were lower than those in the control group(P<0.05).Conclusion:Bushen Jiangu decoction can effectively regulate bone metabolism index,sex hormone level and cytokine level,enhance bone density,improve osteoporosis symptoms.

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备注/Memo

备注/Memo:
基金项目:湖南省自然科学基金资助项目(2022JJ70124)
更新日期/Last Update: 2023-06-09