[1]孙青凤,杨君君,任亚娟,等.暖宫消癥散结汤联合中药灌肠治疗子宫腺肌症疗效及对患者痛经症状积分、子宫内膜厚度和血清CA125水平的影响[J].陕西中医,2023,(6):742-745.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.013]
　SUN Qingfeng,YANG Junjun,REN Yajuan,et al.Efficacy of Nuangong Xiaozheng Sanjie decoction combined with traditional Chinese medicine enema on adenomyosis and its effects on dysmenorrhea symptom score,endometrial thickness and serum CA125 level[J].,2023,(6):742-745.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.013]
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暖宫消癥散结汤联合中药灌肠治疗子宫腺肌症疗效及对患者痛经症状积分、子宫内膜厚度和血清CA125水平的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年6期
页码:
742-745
栏目:
临床研究
出版日期:
2023-06-05

文章信息/Info

Title:
Efficacy of Nuangong Xiaozheng Sanjie decoction combined with traditional Chinese medicine enema on adenomyosis and its effects on dysmenorrhea symptom score,endometrial thickness and serum CA125 level
作者:
孙青凤; 杨君君; 任亚娟; 谭兴民
(四川省中西医结合医院,四川 成都 610041)
Author(s):
SUN Qingfeng; YANG Junjun; REN Yajuan; TAN Xingmin
(Sichuan Integrative Medicine Hospital,Chengdu 610041,China)
关键词:
子宫腺肌症;  暖宫消癥散结汤;  中药灌肠;  寒凝血瘀证;  子宫内膜厚度;  子宫体积;  血清糖类抗原125
Keywords:
Adenomyosis;  Nuangong Xiaozheng Sanjie decoction;  Traditional Chinese medicine enema;  Cold coagulation and blood stasis syndrome;  Endometrial thickness;  Uterine volume;  Carbohydrate antigen 125
分类号:
R 711.74
DOI:
DOI:10.3969/j.issn.1000-7369.2023.06.013
文献标志码:
A
摘要:
目的:探究暖宫消癥散结汤联合中药灌肠治疗子宫腺肌症的临床疗效,以及对患者痛经、子宫内膜厚度和血清糖类抗原125(CA125)水平的影响。方法:选取70例子宫腺肌症患者,且中医证型为寒凝血瘀证,按照随机数字表法分为观察组和对照组各35例。对照组患者予口服优思明片联合中药灌肠治疗,观察组患者在对照组基础上加予暖宫消癥散结汤,两组均治疗21 d。比较两组患者临床有效率、中医症状积分、子宫内膜厚度、子宫体积、子宫压触痛、血清CA125。记录治疗期间不良反应。结果:治疗后,观察组临床有效率88.57%高于对照组68.57%(P<0.05); 治疗后,两组中医症状各主症及次症积分均降低(P<0.05),且观察组治疗后积分低于对照组(P<0.05); 治疗后,两组子宫内膜厚度、子宫体积、子宫压触痛评分均降低(P<0.05),且观察组治疗后上述指标均低于对照组(P<0.05); 治疗后,两组血清CA125水平均下降(P<0.05),且观察组治疗后CA125低于对照组(P<0.05); 两组均未见明显不良反应。结论:暖宫消癥散结汤联合中药灌肠治疗子宫腺肌症能取得更好的临床疗效,改善患者症状,降低血清CA125水平和子宫内膜厚度。
Abstract:
Objective:To explore the clinical efficacy of Nuangong Xiaozheng Sanjie decoction combined with traditional Chinese medicine enema in the treatment of adenomyosis and its effects on dysmenorrhea,endometrial thickness and serum CA125 level.Methods:70 patients with adenomyosis were selected with TCM syndrome type of cold coagulation and blood stasis syndrome,and they were divided into observation group(n=35)and control group(n=35)by the random number table method.The patients in the control group were treated with oral Yasmin tablets combined with traditional Chinese medicine enema while the patients in the observation group were additionally given Nuangong Xiaozheng Sanjie decoction on the basis of the control group.Both groups were treated for 21 days.The clinical effective rate,TCM symptoms scores,endometrial thickness,uterine volume,uterine tenderness and serum carbohydrate antigen 125(CA125)were compared between the two groups of patients.Adverse reactions during treatment were recorded.Results:After treatment,the clinical effective rate in observation group(88.57%)was higher than that in control group(68.57%,P<0.05).After treatment,the scores of primary and secondary TCM symptoms in the two groups were decreased(P<0.05),and the scores in observation group after treatment were lower than those in control group(P<0.05).The endometrial thickness,uterine volume and uterine tenderness score after treatment were reduced in the two groups(P<0.05),and the above indicators after treatment were lower in observation group compared with those in control group(P<0.05).After treatment,the level of serum CA125 in both groups was declined(P<0.05),and the CA125 level in observation group after treatment was lower compared with that in control group(P<0.05).There were no obvious adverse reactions in the two groups.Conclusion:Nuangong Xiaozheng Sanjie decoction combined with traditional Chinese medicine enema can achieve good clinical efficacy in the treatment of adenomyosis,improve the symptoms,and reduce the level of serum CA125 and endometrial thickness.

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备注/Memo

备注/Memo:
基金项目:四川省中医药管理局科技技术研究专项课题(2018LC007)
更新日期/Last Update: 2023-06-09