[1]徐爱平,王夜明,贺贤丽,等.破格救心汤加减治疗脓毒症心肌功能障碍疗效研究[J].陕西中医,2023,(7):877-880.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.011]
　XU Aiping,WANG Yeming,HE Xianli,et al.Clinical study on effect of modified Poge Jiuxin decoction on sepsis with myocardial dysfunction[J].,2023,(7):877-880.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.011]
点击复制

破格救心汤加减治疗脓毒症心肌功能障碍疗效研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年7期
页码:
877-880
栏目:
临床研究
出版日期:
2023-07-05

文章信息/Info

Title:
Clinical study on effect of modified Poge Jiuxin decoction on sepsis with myocardial dysfunction
作者:
徐爱平1; 王夜明1; 贺贤丽2; 游 莎1
(1.湖北省中西医结合医院,湖北 武汉430015; 2.武汉市中医医院,湖北 武汉430014)
Author(s):
XU Aiping; WANG Yeming; HE Xianli; YOU Sha
(Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Wuhan 430015,China)
关键词:
心肌功能障碍;  脓毒症;  破格救心汤;  炎症因子;  肾功能;  不良反应
Keywords:
Myocardial dysfunction;  Sepsis;  Poge Jiuxin decoction;  Inflammatory factor;  Kidney function;  Adverse effect
分类号:
R 542.2
DOI:
DOI:10.3969/j.issn.1000-7369.2023.07.011
文献标志码:
A
摘要:
目的:研究破格救心汤加减治疗脓毒症心肌功能障碍患者的临床疗效。方法:将70例脓毒症心肌功能障碍患者列为试验对象,以随机数字表法将其分为对照组(n=35)、观察组(n=35)。对照组予以西医常规治疗,观察组行破格救心汤加减。比较两组临床治疗效果以及治疗前后心功能指标、血浆脑钠尿肽(BNP)、血清炎症因子水平、肾功能、不良反应发生情况。结果:观察组治疗总有效率94.29%高于对照组74.29%,差异有统计学意义(P<0.05)。观察组治疗后左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、每分心输出量(CO)、BNP、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)改善程度均优于对照组(P<0.05)。治疗后两组患者白蛋白(Alb)、血肌酐(Scr)比较,差异无统计学意义(均P>0.05)。观察组在治疗期间出现2例腹泻、1例痛风; 对照组在治疗期间出现3例腹泻、1例痛风,两组患者均经对症治疗后好转; 两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:破格救心汤加减治疗脓毒症心肌功能障碍疗效较好,能改善患者心功能、炎症因子水平,促进康复。
Abstract:
Objective:To study clinical effect of modified Poge Jiuxin decoction on septic patients with myocardial dysfunction.Methods:70 patients with septic myocardial dysfunction were selected as the experimental subjects and divided into control group(n=35)and observation group(n=35)according to the random number table.The control group were treated with western medicine,and the observation group treated with modified Poge Jiuxin decoction.The clinical effects,cardiac function indexes,plasma brain natriuretic peptide(BNP),serum inflammatory factor levels,renal function,and incidence of adverse reactions before and after treatment were compared.Results:The total effective rate in the treatment group 94.29% was higher than that in the control group 74.29%,difference statistically significant(P<0.05).After treatment,the indexes of left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),cardiac output per minute(CO),BNP,interleukin -10(IL-10),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were better than those in the control group(P<0.05).After treatment,the data comparisons of albumin(Alb)and serum creatinine(Scr)showed no difference between the two groups(all P>0.05).Two cases of diarrhea one case of gout in the observation group and three cases of diarrhea one case of gout in the control group during the treatment were observed.The symptoms of the two groups were improved after symptomatic treatment.There was no significant difference in the incidence of adverse reactions between the two groups,difference not statistically significant(P>0.05).Conclusion:The modified Poge Jiuxin decoction has significant effect on the treatment of septic patients with myocardial dysfunction,which is conducive to improving cardiac function,levels of inflammatory factors and rehabilitation.

参考文献/References:

[1] 魏 巍,甘桂芬,童世君,等.血液净化联合乌司他丁对脓毒症急性肺损伤患者血清VEGF-内皮素受体及CRP-Hcy水平的影响[J].河北医药,2022,44(9):1346-1349.
[2] 化学胜,曹 磊,王岳鹏.rh-BNP联合左西孟旦对老年脓毒症患者心肌功能障碍的临床疗效及安全性评价[J].同济大学学报:医学版,2022,43(1):100-106.
[3] 龙 敏,张玉琴,岳 煜,等.黄连解毒汤联合西药治疗脓毒症心肌损伤疗效研究[J].陕西中医,2022,43(3):329-333.
[4] 中国医师协会急诊医师分会,中国研究型医院学会休克与脓毒症专业委员会.中国脓毒症/脓毒性休克急诊治疗指南[J].感染、炎症、修复,2019,20(1):3-22.
[5] Rhodes A,Evans LE.Surviving sepsis campaign:International guidelines for management of sepsis and septic shock[J].Intensive Care Med,2017,43(3):304-377.
[6] 朱 弢,郑伟青,黄伟剑.破格救心汤加减治疗急性心肌梗死PCI术后伴心源性休克疗效及对血清指标的影响[J].浙江中医杂志,2021,56(12):880-881.
[7] 王育怀,刘嘉琪,何志广,等.破格救心汤治疗急性心力衰竭的疗效观察[J].中国中医急症,2021,30(10):1808-1811.
[8] 陆小强,黄惠铁,何成辉.破格救心汤联合西药治疗慢性肺源性心脏病并心力衰竭的临床观察[J].内蒙古中医药,2021,40(9):22-23.
[9] 邓贤斌,陈路军,方艳琳,等.破格救心汤的圆运动解析及临床应用拓展[J].中医药导报,2021,27(9):183-186.
[10] 朱登攀.破格救心汤加减在急性心肌梗死合并心源性休克PCI术后患者中的应用观察[J].实用中西医结合临床,2021,21(16):11-12.
[11] 李丽萍,张平平,王东强,等.中医清热解毒治法在脓毒症中的应用[J].中国中医急症,2020,29(5):867-869.
[12] 张育芳,张 谦,王忆梅.中医方剂在脓毒症辅助治疗中的辨证应用[J].陕西中医,2019,40(8):1105-1108.
[13] 卢振峰.益气扶正、化瘀解毒法对脓毒症凝血功能障碍影响的临床探讨[J].世界最新医学信息文摘,2019,19(5):197,206.
[14] 黄亚秀,李少萍,黄永莲,等.破格救心汤治疗脓毒性心肌病(心肾阳虚证)的临床研究[J].中国中医急症,2021,30(7):1178-1181.
[15] 王月峰,张翠利,张天栋,等.破格救心汤加减对心力衰竭模型大鼠心肌能量代谢的干预作用及机制研究[J].中国中医基础医学杂志,2021,27(5):745-748.
[16] 李春霞.破格救心汤联合针刺治疗慢性肺源性心脏病临床研究[J].四川中医,2021,39(5):69-73.
[17] 黄亚秀,李少萍,黄永莲,等.破格救心汤治疗脓毒性休克的疗效观察[J].中国中医急症,2021,30(3):488-491.
[18] 王 铮,禄文博,郝如斌,等.基于“阳微阴弦”理论探讨破格救心汤在脓毒性心肌病治疗中的应用[J].中国中西医结合急救杂志,2022,29(2):238-241.
[19] 吴河山,马志仁,刘守亮,等.加味破格救心汤2号对阳虚水泛兼血瘀型慢性肺心病患者血液流变学和心功能的影响[J].西部中医药,2022,35(7):65-67.
[20] 杨李旺,杨 蓉,赵焕新,等.黄连解毒汤通过诱导自噬减轻脓毒症小鼠肝损伤[J].中国试验方剂学杂志,2022,28(5):71-76.
[21] 付智慧,赵灵灵,周 霖,等.基于网络药理学探讨大承气汤治疗脓毒症的作用机制及关键靶点通路验证[J].中国中药杂志,2021,46(20):5351-5361.
[22] 王 婷,韦小碗,杨 亮,等.脓毒症患者血清PCT、CRP、IL-6和IL-10水平检测及临床意义[J].陕西医学杂志,2020,49(11):1510-1514.
[23] 何 芸,张卫卫,孔祥云.血清白细胞介素-6、肿瘤坏死因子-α、活性氧在食管癌术后并发心房颤动患者体内表达水平及检测意义[J].陕西医学杂志,2022,51(7):816-819.
[24] 杨海茹,张文宁.B超定位引导穿刺冲洗治疗肝脓肿疗效及对患者血清IL-6、IL-8、TNF-α因子水平的影响[J].陕西医学杂志,2019,48(11):1474-1476,1499.

相似文献/References:

[1]曹 佳,杨华英,何 艺,等.姜黄素通过激活SIRT1调节脓毒症小鼠模型的认知功能障碍研究*[J].陕西中医,2020,(3):301.
　CAO Jia,YANG Huaying,HE Yi,et al.Curcumin regulates cognitive dysfunction in sepsis mice by activating SIRT1[J].,2020,(7):301.
[2]李秀娟,肖亚平,周 钰.电针改善小鼠脓毒症后认知功能障碍作用及机制研究[J].陕西中医,2021,(2):139.[doi:DOI:10.3969/j.issn.1000-7369.2020.02.001]
　LI Xiujuan,XIAO Yaping,ZHOU Yu.Effect and mechanism of electroacupuncture on cognitive dysfunction after sepsis in mice[J].,2021,(7):139.[doi:DOI:10.3969/j.issn.1000-7369.2020.02.001]

备注/Memo

备注/Memo:
基金项目:湖北省卫生健康委员会科研项目(WJ2019F168)
更新日期/Last Update: 2023-07-10