[1]郭传琦,艾 健.温肾泄浊汤治疗慢性肾衰竭73例疗效研究[J].陕西中医,2023,(9):1237-1240.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.018]
　GUO Chuanqi,AI Jian.Effect of Wenshen Xiezhuo decoction on chronic renal failure[J].,2023,(9):1237-1240.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.018]
点击复制

温肾泄浊汤治疗慢性肾衰竭73例疗效研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年9期
页码:
1237-1240
栏目:
临床研究
出版日期:
2023-09-05

文章信息/Info

Title:
Effect of Wenshen Xiezhuo decoction on chronic renal failure
作者:
郭传琦; 艾 健
(秦皇岛市中医医院,河北 秦皇岛 066000)
Author(s):
GUO Chuanqi; AI Jian
(Qinhuangdao Chinese Medicine Hospital,Qinhuangdao 066000,China)
关键词:
慢性肾衰竭;  温肾泄浊汤;  血液透析;  肾功能;  氧化应激;  营养状况
Keywords:
Chronic kidney failure;  Wenshen Xiezhuo decoction;  Hemodialysis;  Kidney function;  Oxidative stress;  Nutritional status
分类号:
R 692.5
DOI:
DOI:10.3969/j.issn.1000-7369.2023.09.018
文献标志码:
A
摘要:
目的:研究温肾泄浊汤治疗慢性肾衰竭的疗效及对患者肾功能、氧化应激指标与营养状况的影响。方法:146例慢性血液透析肾衰竭患者随机分为对照组(73例)和观察组(73例)。对照组采用血液透析进行治疗,观察组采用血液透析、温肾泄浊汤进行治疗,两组均治疗4周。统计分析两组临床疗效、中医症状积分、氧化应激指标、营养状态指标及肾功能。结果:治疗4周后,观察组总有效率更高(P<0.05)。治疗4周后与治疗前比较,两组恶心、呕吐、肢体困重、食少纳呆、脘腹胀满、口中黏腻评分、血清丙二醛(MDA)、晚期氧化蛋白产物(AOPP)、透明质酸(HA)、转化生长因子-β1(TGF-β1)、血肌酐(Scr)、尿素氮(BUN)水平及24 h尿蛋白(24 h-UTP)水平均降低,观察组相对更低(P<0.05)。治疗4周后与治疗前比较,两组血清超氧化物歧化酶(SOD)、总抗氧化能力(TAC)、白蛋白(ALB)、血红蛋白(HGB)、转铁蛋白(TRF)、骨形成蛋白-7(BMP-7)水平及主观综合性营养评分、肾小球滤过率(eGFR)均升高,观察组相对更高(P<0.05)。结论:温肾泄浊汤可改善慢性肾衰竭患者中医症状,抑制机体氧化应激,缓解患者肾纤维化,提高机体营养状态及肾功能,具有较好的治疗效果。
Abstract:
Objective:To study the therapeutic effect of Wenshen Xiezhuo decoction on chronic renal failure and its influence on renal function,oxidative stress index and nutritional status of patients.Methods:146 patients with chronic renal failure were divided into the control group(73 cases)and the observation group(73 cases).The control group was treated with hemodialysis,and the observation group was treated with hemodialysis and warm Wenshen Xiezhuo decoction.Both groups were treated for 4 weeks.Clinical efficacy,TCM symptom score,oxidative stress index,nutritional status index and renal function of the two groups were analyzed.Results:After 4 weeks of treatment,the total effective rate of the observation group was higher(P<0.05).After 4 weeks of treatment,compared with before treatment,scores of nausea,vomiting,body weight,eating less and eating less,abdominal distension,mouth viscosity,levels of serum malondialdehyde(MDA),advanced oxidized protein product(AOPP),hyaluronic acid(HA),transforming Growth factor-β1(TGF-β1),blood creatinine(Scr),urea nitrogen(BUN)levels and 24 h urinary protein(24 h-UTP)decreased in both groups,the observation group was lower(P<0.05).After 4 weeks of treatment,compared with before treatment,levels of serum SOD,TAC,albumin(ALB),hemoglobin(HGB),transferrin(TRF),bone morphogenetic protein-7(BMP-7),subjective comprehensive nutrition score and glomerular filtration rate(eGFR)in two groups increased,and the observation group was higher(P<0.05).Conclusion:Wenshen Xiezhuo decoction could improve the symptoms of traditional Chinese medicine of patients with chronic renal failure,inhibit the oxidative stress of the body,relieve the renal fibrosis of patients,improve the nutritional state of the body and kidney function,and had a good therapeutic effect.

参考文献/References:

[1] 王元真,陈兴强,赵汉儒.丹参多酚酸盐、前列地尔、谷胱甘肽三联疗法治疗慢性肾功能衰竭疗效及对患者eGFR水平的影响[J].陕西医学杂志,2018,47(10):1343-1345.
[2] 周承朋,柳书芬,唐小勇,等.肾衰竭患者血清sFlt-1、血肌酐表达情况及其临床意义研究[J].陕西医学杂志,2017,46(9):1296-1298.
[3] 白 石,毕丽丽.血液透析联合血液灌流治疗对慢性肾衰竭患者临床疗效、肾功能及炎性因子的影响研究[J].贵州医药,2022,46(5):701-702.
[4] 王艳文,李小会,陈丽名,等.活用“去宛陈莝”理论治疗慢性肾衰竭[J].吉林中医药,2022,42(1):28-32.
[5] 刘宵琴,刘力沛,杨小冬.参芪降浊方口服及熏蒸汽浴治疗慢性肾衰竭脾虚湿浊证52例[J].环球中医药,2022,15(9):1672-1676.
[6] 范 菁,远 方.益肾泄浊汤治疗肾虚湿浊型慢性肾衰竭的临床研究[J].现代中西医结合杂志,2022,31(4):480-484.
[7] 张晓霞,赵 莲,朱日霞,等.家属参与式护理管理模式对慢性肾衰竭腹膜透析患者及家属的干预效果研究[J].长春中医药大学学报,2021,37(4):864-867.
[8] 王海燕.肾脏病学[M].北京:人民卫生出版社,2008:47-52.
[9] 王 钢,陈以平,邹燕勤.现代中医肾脏病学[M].北京:人民卫生出版社,2003:54-58.
[10] 李慧灵,张建德,叶 静,等.加味玉液汤治疗气阴两虚型糖尿病肾病慢性肾衰竭疗效及对患者微炎症状态的影响[J].陕西中医,2022,43(8):1064-1067.
[11] Cigremis Y,Ozen H,Durhan M,et al.Effects of caffeic acid phenethyl ester use and inhibition of p42/44 map kinase signal pathway on caveolin 1 gene expression and antioxidant system in chronic renal failure model of rats[J].Drug Chem Toxicol,2023,46(2):197-208.
[12] 张志勇,李明旭,于 海,等.自动化腹膜透析对终末期肾衰竭患者心功能和临床症状的影响[J].陕西医学杂志,2020,49(9):1130-1133.
[13] 魏 华,王佳丽,杨玉霞.百令胶囊对慢性肾衰竭腹膜透析患者营养状况及微炎症状态的影响[J].陕西中医,2019,40(6):764-766.
[14] 李 丹,谷学梅.血液透析用于慢性肾功能衰竭合并急性心力衰竭临床治疗的价值评价[J].陕西医学杂志,2018,47(9):1161-1163.
[15] 郑 栓,万红波,郑建国,等.健脾补肾活血泄浊方联合杂合式血液净化疗法对慢性肾衰竭患者肾功能及血清CD4+/CD8+水平的影响[J].陕西中医,2019,40(2):188-191.
[16] 王 波,肖 健,刘正萌,等.黄芪益肾颗粒联合腹膜透析对慢性肾衰竭肾功能及血清miR-30a、Hcy、CysC表达影响[J].中华中医药学刊,2022,40(6):161-165.
[17] 吴睿轩,胡振奋.益肾泄浊汤联合基础治疗肾虚湿浊证慢性肾脏病3～5期疗效及对血清FGF23和Klotho蛋白及钙磷代谢的影响[J].中华中医药学刊,2021,39(11):228-232.
[18] 陈岳尧,黎海翔,符妹丽.尿毒清颗粒保留灌肠辅助西医基础疗法治疗慢性肾衰竭临床疗效及对患者肾功能、氧化应激、免疫功能的影响[J].湖北中医药大学学报,2022,24(4):33-36.
[19] 赵文娟,夏世国,王 秦.百令胶囊辅助维持性血液透析对慢性肾衰竭尿毒症期患者微炎症状态及残余肾功能的影响[J].中国中西医结合肾病杂志,2022,23(11):1013-1015.
[20] 蒋宏伟,杜浩昌,杜 渊.黄葵胶囊联合复方α酮酸片治疗慢性肾衰竭的疗效及对Scr、BUN水平影响[J].中华中医药学刊,2021,39(9):244-248.

相似文献/References:

[1]郑 栓,万红波,郑建国,等.健脾补肾活血泄浊方联合杂合式血液净化疗法对慢性肾衰竭患者 肾功能及血清CD4+/CD8+水平的影响*[J].陕西中医,2019,(2):188.
　ZHENG Shuan,WAN Hongbo,ZHENG Jianguo,et al.Effect of Jianpi Bushen Huoxue Xiezhuo decoction combined with hybrid blood purification therapy on renal function and serum CD4+/CD8+ levels in patients with chronic renal failure[J].,2019,(9):188.
[2]张春艳,李 浩,李 娜,等.肾浊清颗粒含药血清对肾小管上皮细胞TGFβ/Smads信号传导的影响*[J].陕西中医,2019,(10):1323.
　ZHANG Chunyan,LI Hao,LI Na,et al.Effect of Shenzhuoqing granulecontaining serum on TGFβ/Smads signal transduction in renal tubular epithelial cells[J].,2019,(9):1323.
[3]王世卫,韩 佳,马民凯△,等.健脾补肾活血化瘀法治疗慢性肾功能衰竭疗效及对患者肾功能的影响*[J].陕西中医,2020,(11):1598.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.022]
[4]陈小燕,杨敏生,曹 雯.肾衰复元汤治疗慢性肾衰竭疗效观察[J].陕西中医,2021,(10):1397.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.018]
[5]李慧灵,张建德,叶 静,等.加味玉液汤治疗气阴两虚型糖尿病肾病慢性肾衰竭疗效及对患者微炎症状态的影响[J].陕西中医,2022,(8):1064.[doi:DOI:10.3969/j.issn.1000-7369.2022.08.018]
[6]王艳芬,马 琴,王 顺.肾康注射液联合穴位敷贴治疗慢性肾功能衰竭疗效及作用机制[J].陕西中医,2023,(5):595.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.012]
　WANG Yanfen,MA Qin,WANG Shun.Effects and mechanism of action of Shenkang injection combined with acupoint application on chronic renal failure[J].,2023,(9):595.[doi:DOI:10.3969/j.issn.1000-7369.2023.05.012]
[7]刘文君,王亿平,吕 伟,等.益气护肾方佐治慢性肾衰竭3～5期肾气虚夹瘀临床研究[J].陕西中医,2024,(8):1056.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.010]
　LIU Wenjun,WANG Yiping,LYU Wei,et al.Clinical efficacy of Yiqi Hushen decoction adjuvant therapy on patients with stage 3～5 chronic renal failure with syndrome of kidney deficiency and blood stasis[J].,2024,(9):1056.[doi:DOI:10.3969/j.issn.1000-7369.2024.08.010]
[8]罗玉芳,李怀玉,吕森浩,等.肾衰泄浊汤对腺嘌呤致肾阳虚型慢性肾衰竭大鼠下丘脑-垂体-肾上腺轴的影响[J].陕西中医,2024,(9):1161.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.002]
　LUO Yufang,LI Huaiyu,LYU Senhao,et al.Effects of Shenshuai Xiezhuo decoction on HPA axis in rats with chronic renal failure of kidney-yang deficiency caused by adenine[J].,2024,(9):1161.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.002]

备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研计划项目(2020374); 河北省秦皇岛市科技局科研计划项目(202004A102)
更新日期/Last Update: 2023-09-08