[1]安致稳,阴雅男,李 卓,等.子午流注针法联合中药熏蒸治疗水样液缺乏性干眼症疗效研究[J].陕西中医,2023,(9):1297-1301.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.033]
　AN Zhiwen,YIN Yanan,LI Zhuo,et al.The curative effect of meridian ebb injection acupuncture combined with traditional chinese medicine fumigation on dry eye caused by water sample deficiency[J].,2023,(9):1297-1301.[doi:DOI:10.3969/j.issn.1000-7369.2023.09.033]
点击复制

子午流注针法联合中药熏蒸治疗水样液缺乏性干眼症疗效研究
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年9期
页码:
1297-1301
栏目:
针灸经络
出版日期:
2023-09-05

文章信息/Info

Title:
The curative effect of meridian ebb injection acupuncture combined with traditional chinese medicine fumigation on dry eye caused by water sample deficiency
作者:
安致稳; 阴雅男; 李 卓; 杨玉青
(唐山市中医医院眼科,河北 唐山 063000)
Author(s):
AN Zhiwen; YIN Yanan; LI Zhuo; YANG Yuqing
(Department of Ophthalmology,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China)
关键词:
干眼症;  水样液缺乏性;  子午流注针法;  中药熏蒸;  泪膜稳定性;  泪液分泌量
Keywords:
Dry eye;  Water sample deficiency;  Meridian ebb injection acupuncture;  Traditional Chinese medicine fumigatio;  Tear film stability;  Tear secretion
分类号:
R 777.16
DOI:
DOI:10.3969/j.issn.1000-7369.2023.09.033
文献标志码:
A
摘要:
目的:探讨子午流注针法联合中药熏蒸治疗水样液缺乏性干眼症的疗效及对患者泪膜稳定性的影响。方法:依据随机数字表法分配原则将110例水样液缺乏性干眼症患者分为对照组(55例)和治疗组(55例)。对照组给予聚乙二醇滴眼液进行治疗,治疗组在对照组基础上给予子午流注针法联合中药熏蒸进行治疗,两组均持续治疗6周。比较两组治疗6周后的临床疗效,对比两组治疗前及治疗6周后的症状积分、泪膜稳定性、细胞因子、视觉相关生命质量及治疗期间的安全性。结果:治疗组治疗6周后的总有效率为94.55%,高于对照组的78.18%(P<0.05)。治疗6周后,两组眼干涩、异物感、视疲劳、畏光、眼红、眼胀痛、泪液分泌量(SIT)、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分及血清基质金属蛋白酶-9(MMP-9)、白细胞介素-1β(IL-1β)、泪液白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)水平与治疗前比较均降低,治疗组低于对照组(P<0.05); 两组视力障碍、活动障碍、一般健康状况评分与治疗前比较均升高,治疗组高于对照组(P<0.05)。两组治疗期间均未出现腹泻、眼部刺激、过敏等情况。结论:子午流注针法联合中药熏蒸可明显调节水样液缺乏性干眼症患者血清细胞因子水平,缓解机体炎症,提高泪膜稳定性,改善临床症状,进而可促进患者视觉相关生命质量的提高,疗效显著,安全性良好。
Abstract:
Objective:To investigate the curative effect of meridian ebb injection acupuncture combined with traditional Chinese medicine fumigation on dry eye caused by water sample deficiency and its influence on tear film stability of patients.Methods:According to the principle of random number table,110 patients with dry eye syndrome caused by water sample deficiency were divided into control and treatment group with 55 case in each.The control group and the treatment group were treated with polyethylene glycol eye drops,meridian ebb injection acupuncture combined with traditional Chinese medicine fumigation and polyethylene glycol eye drops.Both groups continued to be treated for 6 weeks. Between the two groups,the clinical efficacy after 6 weeks of treatment,the score of symptom,tear film stability,cytokine,visual-related quality of life before and after 6 weeks of treatment and the safety during treatment were compared.Results:The rate of total effective in the treatment group was 94.55%,higher than after 6 weeks of treatment 78.18% in the control group(P<0.05).After 6 weeks of treatment,the scores of dry eye,foreign body sensation,visual fatigue,photophobia,redness,eye swelling and pain,tear secretion(SIT),tear film rupture time(BUT),corneal fluorescein staining(FL)and serum levels of matrix metalloproteinase-9(MMP-9),interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor in tear-α(TNF-α),hypersensitive C-reactive protein(hs-CRP)in the both groups were lower than before,the treatment group was lower(P<0.05).The scores of visual impairment,activity impairment and general health status in the both groups were higher than before,the treatment group was lower(P<0.05).No diarrhea,eye irritation,allergy,etc.in the two groups during the treatment.Conclusion:Meridian ebb injection acupuncture combined with traditional Chinese medicine fumigatio could significantly regulate the level of serum cytokines in patients with dry eye caused by water sample deficiency,alleviate the inflammation of the body,improve the stability of the patient's tear film,improve the clinical symptoms,and further promote the improvement of patients' visual-related quality of life,with significant curative effect and with higher safety.

参考文献/References:

[1] 朱佳丽,李卫红.重组人表皮生长因子联合氟米龙滴眼液对儿童干眼症临床效果、眼表功能和生活质量的影响[J].贵州医药,2022,46(12):1938-1939.
[2] Postnikoff CK,Huisingh C,Mc GG,et al.Leukocyte distribution in the open eye tears of normal and dry eye subjects[J].Curr Eye Res,2018,43(10):1253-1259.
[3] 李 欣,刘玉秋,臧冬晓,等.丹栀逍遥散加减联合聚乙二醇滴眼液治疗干眼症疗效观察[J].四川中医,2022,40(2):165-168.
[4] 朱华英,项敏泓,陈 峰,等.针刺配合中药及人工泪液治疗肝肾阴亏型泪液缺乏性干眼症的疗效观察[J].上海针灸杂志,2019,38(4):421-428.
[5] 赵 丽,胡小凤,许邦丽.中药熏蒸联合人工泪液治疗干眼症的临床观察及对患者视觉相关生命质量的影响[J].世界中医药,2019,14(4):903-906.
[6] 杨翔宇,王兴才,彭旭明.温针灸联合子午流注纳子针法对老年腰椎管狭窄症患者疗效及相关炎症因子的影响[J].中医药导报,2022,28(11):41-44,50.
[7] 中华医学会眼科学分会角膜病学组.干眼临床诊疗专家共识(2020年)[J].中华眼科杂志,2020,56(12):907-911.
[8] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:251-253.
[9] 陈 军,李 静.子午流注反克开穴法浅析[J].长春中医药大学学报,2009,25(3):322,346.
[10] 中华人民共和国卫生部.中医新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:89-90.
[11] 刘祖国.干眼[M].北京:人民卫生出版社,2017:83.
[12] Suner IJ,Kokame GT,Yu E,et al.Responsiveness of nei vfq-25 to changes in visual acuity in neovascular amd:Validation studies from two phase 3 clinical trials[J].Investigative Ophthalmology & Visual Science,2009,50(8):3629-3635.
[13] 孙 明,王蔚文.临床疾病诊断及疗效判定标准[M].北京:中国科学技术文献出版社,2010:55-57.
[14] 马文婷,赵 铭,王 升,等.自体血清联合玻璃酸钠治疗白内障术后干眼症疗效及对患者泪液炎症因子的影响[J].陕西医学杂志,2022,51(9):1129-1132.
[15] 任娜欣.芪明颗粒联合氟米龙滴眼液治疗儿童中重度干眼症的疗效观察[J].陕西中医,2018,39(1):26-28.
[16] Lubis RR,Gultom MTH.The correlation between daily lens wear duration and dry eye syndrome[J].Open Access Maced J Med Sci,2018,6(5):829-834.
[17] 张 蕊,李 能,来 坚.“过眼热”针刺治疗干眼症患者临床疗效[J].辽宁中医杂志,2022,49(7):181-184.
[18] 刘 婧,韩德雄,王 超,等.埋线调节水液缺乏型干眼症泪液分泌状况的临床研究[J].中华中医药杂志,2020,35(1):476-479.
[19] 王少琴,刘丽彬.子午流注纳子法结合温通针法对缺血性脑卒中患者下肢肢体功能康复及脑血流水平的影响[J].陕西中医,2022,43(4):523-526.
[20] 许 宁,吴冬梅,陶 冶,等.针刺联合中药熏蒸治疗干眼症的临床观察[J].中国临床医生杂志,2020,48(11):1377-1378.
[21] 余秋燕,岳丽菁,唐 敏.中药熏服治疗肝郁脾虚型干眼症的临床疗效观察[J].广州中医药大学学报,2022,39(3):551-555.
[22] 郭康杰,李建超,王芮文.迎香穴透刺鼻通穴治疗干眼症临床观察及对炎症因子水平影响[J].吉林中医药,2021,41(4):481-484.
[23] Nikseresht T,Abdi A,Khatony A.Effectiveness of polyethylene cover versus polyethylene cover with artificial tear drop to prevent dry eye in critically ill patients:A randomized controlled clinical trial[J].Clin Ophthalmol,2019,13(12):2203-2210.
[24] 张丹丹,杨迎新,马朝廷,等.中药熏蒸疗法治疗干眼症的临床效果分析[J].沈阳药科大学学报,2021,38(S2):75.
[25] 左建霞,冯艳霞,孙朝晖,等.中药熏眼联合睑板腺按摩治疗白内障术后干眼症疗效观察[J].现代中西医结合杂志,2021,30(15):1637-1641,1646.

相似文献/References:

[1]葛莉莉.玻璃酸钠滴眼液联合中药外熏治疗干眼症疗效及安全性Meta分析[J].陕西中医,2021,(10):1474.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.040]
　GE Lili.A Meta-analysis of the efficacy and safety of sodium hyaluronate eye drops combined with herbal fumigation in the treatment of dry eye disease[J].,2021,(9):1474.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.040]
[2]魏文娟,韩治华,杨永红,等.中药穴位离子导入联合眼部刮痧治疗泪液分泌减少型干眼症临床研究[J].陕西中医,2023,(1):115.[doi:DOI:10.3969/j.issn.1000-7369.2023.01.028]
　WEI Wenjuan,HAN Zhihua,YANG Yonghong,et al.Clinical study of traditional Chinese medicine acupoint iontophoresis combined with eye scraping treatment in aqueous tear-deficient dry eye[J].,2023,(9):115.[doi:DOI:10.3969/j.issn.1000-7369.2023.01.028]
[3]常彩霞,王新军,王开琦,等.润眼明目方熏蒸联合睑板腺按摩治疗干眼症临床研究[J].陕西中医,2023,(3):324.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.012]
　CHANG Caixia,WANG Xinjun,WANG Kaiqi,et al.Clinical study on Runyan Mingmu decoction fumigation combined with meibomian gland massage for xerophthalmia[J].,2023,(9):324.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.012]

备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研项目(2021390)
更新日期/Last Update: 2023-09-08