[1]杨 艺,王 伟,寇然冰,等.外泌体在消化系统疾病中的作用机制及中药干预研究进展[J].陕西中医,2023,(10):1478-1481,1486.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.033]
　YANG Yi,WANG Wei,KOU Ranbing,et al.Mechanism of exosomes in digestive system diseases and research progress of traditional Chinese medicine intervention[J].,2023,(10):1478-1481,1486.[doi:DOI:10.3969/j.issn.1000-7369.2023.10.033]
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外泌体在消化系统疾病中的作用机制及中药干预研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年10期
页码:
1478-1481,1486
栏目:
综 述
出版日期:
2023-10-05

文章信息/Info

Title:
Mechanism of exosomes in digestive system diseases and research progress of traditional Chinese medicine intervention
作者:
杨 艺; 王 伟; 寇然冰; 王佑辉; 路士华
(山东中医药大学附属医院,山东 济南 250014)
Author(s):
YANG Yi; WANG Wei; KOU Ranbing; WANG Youhui; LU Shihua
(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)
关键词:
消化系统疾病;  外泌体;  中药单体;  中药复方;  信号通路
Keywords:
Digestive system diseases;  Exosomes;  Traditional Chinese medicine monomer;  Traditional Chinese medicine compound;  Signal channel
分类号:
R 57
DOI:
DOI:10.3969/j.issn.1000-7369.2023.10.033
文献标志码:
A
摘要:
通过干预信号通路、激活炎症因子、干扰免疫反应、抑制细胞转化等途径,外泌体在消化系统领域发挥着不可或缺的作用,如反流性食管炎、胃溃疡、炎症性肠病、病毒性结肠炎、病毒性肝炎、胰腺炎等消化系统疾病及食管肿瘤、胃癌、结肠癌等消化系统肿瘤的发生发展均在一定程度上与外泌体密切相关。并且,相关实验数据和临床经验证实,中药因具有多途径、多靶点、双向调节等特点,中药单体或复方可通过干预外泌体途径,起到治疗消化系统疾病的作用。然而,针对具体疾病的相关研究仍较少,且尚无系统阐述。现通过对外泌体在消化系统疾病中的作用机制及中药的干预作用进行文献检索并加以综述,以期为中医药治疗消化系统疾病提供新的思路与方法。
Abstract:
Exosomes play an indispensable role in the field of digestive system by interfering with signal pathway,activating inflammatory factors,interfering with immune response and inhibiting cell transformation.The occurrence and development of digestive system diseases such as reflux esophagitis,gastric ulcer,inflammatory bowel disease,viral colitis,viral hepatitis,pancreatitis and digestive system tumors such as esophageal tumor,gastric cancer and colon cancer are closely related to exosomes to some extent.Moreover,relevant experimental data and clinical experience have confirmed that Chinese medicine has the characteristics of multi-channel,multi-target and two-way regulation,and single or compound Chinese medicine can play a role in treating digestive system diseases by interfering with exosomes.However,there are still few studies on specific diseases,and there is no systematic exposition.This paper aims to provide new ideas and methods for the treatment of digestive system diseases with traditional Chinese medicine by searching and summarizing the literature on the mechanism of exosomes in digestive system diseases and the intervention effect of traditional Chinese medicine.

参考文献/References:

[1] Pegtel DM,Gould SJ.Exosomes[J].Annu Rev Biochem,2019,88(5):487-514.
[2] 马 骞,朱 军,蔡梦珊,等.基于exoRBase外泌体数据库结直肠癌竞争性内源RNA网络构建及富集分析[J].陕西医学杂志,2021,50(7):797-801.
[3] Uemura R,Murakami Y,Hashimoto A,et al.Expression of serum exosomal and esophageal microrna in rat reflux esophagitis[J].Int J Mol Sci,2017,18(8):1611-1620.
[4] Lin M,Zhou C,He S,et al.The research advances of exosomes in esophageal cancer[J].Biomark Med,2019,13(8):685-695.
[5] Shi S,Huang X,Ma X,et al.Research of the mechanism on miRNA193 in exosomes promotes cisplatin resistance in esophageal cancer cells[J].PLoS One,2020,15(5):125-127.
[6] Fu M,Gu J,Jiang P,et al.Exosomes in gastric cancer:Roles,mechanisms,and applications[J].Mol Cancer,2019,18(1):41-43.
[7] Kahroba H,Hejazi MS,Samadi N.Exosomes:From carcinogenesis and metastasis to diagnosis and treatment of gastric cancer[J].Cell Mol Life Sci,2019,76(9):1747-1758.
[8] Liu H,Li PW,Yang WQ,et al.Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs[J].BMC Cancer,2019,19(1):129-134.
[9] Zhang H,Wang L,Li C,et al.Exosome-induced regulation in inflammatory bowel disease[J].Front Immunol,2019,10(8):1464-1468.
[10] Liu T,Zhang X,Du L,et al.Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer[J].Mol Cancer,2019,18(1):43-48.
[11] 纳 璐,耿盼盼,周 艳,等.MiR-125b-1-3p在轮状病毒复制中的作用研究[J].中华微生物学和免疫学杂志,2021,41(6):433-439.
[12] 杜 静.RV-vsRNA1755靶定轮状病毒VP3调控病毒复制的研究[D].北京:北京协和医学院,2020.
[13] Li S,Li S,Wu S,et al.Exosomes modulate the viral replication and host immune responses in HBV infection[J].Biomed Res Int,2019,32(1):2103-2110.
[14] Yang X,Li H,Sun H,et al.Hepatitis B virus-encoded microrna controls viral replication[J].J Virol,2017,91(10):919-928.
[15] Babuta M,Furi I,Bala S,et al.Dysregulated autophagy and lysosome function are linked to exosome production by micro-RNA 155 in alcoholic liver disease[J].Hepatology,2019,70(6):2123-2141.
[16] Liu G,Ouyang X,Sun Y,et al.The miR-92a-2-5p in exosomes from macrophages increases liver cancer cells invasion via altering the AR/PHLPP/p-AKT/β-catenin signaling[J].Cell Death Differ,2020,27(12):3258-3272.
[17] Zheng H,Wang JJ,Zhao LJ,et al.Exosomal miR-182 regulates the effect of RECK on gallbladder cancer[J].World J Gastroenterol,2020,26(9):933-946.
[18] Jimenez-Alesanco A,Marcuello M,Pastor-Jimenez M,et al.Acute pancreatitis promotes the generation of two different exosome populations[J].Sci Rep,2019,9(1):1988-1996.
[19] Guo C,He J,Song X,et al.Pharmacological properties and derivatives of shikonin:A review in recent years[J].Pharmacol Res,2019,149(3):104-121.
[20] 王延蛟.mRNA/piRNA/piwi在DEN诱导肝癌中的表达及紫草素对肝癌细胞生物学行为的影响[D].乌鲁木齐:新疆医科大学,2021.
[21] 滕 然,蒋益兰.活血化瘀在防治恶性肿瘤转移中的应用[J].陕西中医,2020,41(7):941-944.
[22] Yang Y,Zhang L,La X,et al.Salvianolic acid a inhibits tumor-associated angiogenesis by blocking GRP78 secretion[J].Naunyn Schmiedebergs Arch Pharmacol,2019,392(4):467-480.
[23] Xiong W,Bai X,Xiao H,et al.Effects of Astragaloside Ⅳ on exosome secretion and its microRNA-126 expression in human endothelial progenitor cells[J].Zhonghua Shao Shang Za Zhi,2020,36(12):1183-1190.
[24] Chang JH,Lin CH,Shibu MA,et al.Cryptotanshinone(Dsh-003)from salvia miltiorrhiza bunge inhibits prostaglandin E2-induced survival and invasion effects in HA22T hepatocellular carcinoma cells[J].Environ Toxicol,2018,33(12):1254-1260.
[25] Liang L,Zhao L,Wang Y,et al.Treatment for hepatocellular carcinoma is enhanced when norcantharidin is encapsulated in exosomes derived from bone marrow mesenchymal stem cells[J].Mol Pharm,2021,18(3):1003-1013.
[26] Peng Y,Fan JY,Xiong J,et al.miR-34a Enhances the susceptibility of gastric cancer to platycodin D by targeting survivin[J].Pathobiology,2019,86(5):296-305.
[27] Lin LT,Choong CY,Tai CJ.Solanine attenuated hepatocarcinoma migration and invasion induced by acetylcholine[J].Integr Cancer Ther,2020,19(5):1534-1542.
[28] Wang Y,Zhao L,Yuan W,et al.A natural membrane vesicle exosome-based sinomenine delivery platform for hepatic carcinoma therapy[J].Curr Top Med Chem,2021,10(6):578-589.
[29] Ye Q,Zhou Y,Zhao C,et al.Salidroside inhibits CCl4-Induced liver fibrosis in mice by reducing activation and migration of HSC induced by liver sinusoidal endothelial cell-derived exosomal SphK1[J].Front Pharmacol,2021,12(1):677-686.
[30] 董宏丹.黄芩苷对结肠癌HT-29细胞移植瘤小鼠IL-6/STAT3信号转导通路的影响[J].陕西中医,2021,42(6):696-700.
[31] Tao Y,Zhan S,Wang Y,et al.Baicalin,the major component of traditional Chinese medicine scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs[J].Sci Rep,2018,8(1):132-146.
[32] 彭 娜,卢美君,康马飞,等.白藜芦醇抑制重组人白细胞介素11促进肺腺癌转移灶形成实验研究[J].陕西医学杂志,2020,49(4):401-404.
[33] Liu X,Wang S,Xu J,et al.Extract of stellerachamaejasme L(ESC)inhibits growth and metastasis of human hepatocellular carcinoma via regulating microRNA expression[J].BMC Complement Altern Med,2018,18(1):99-110.
[34] Kim TW,Lee SY,Kim M,et al.DSGOST regulates resistance via activation of autophagy in gastric cancer[J].Cell Death Dis,2018,9(6):649-656.
[35] Chen C,Yao X,Xu Y,et al.Dahuang Zhechong pill suppresses colorectal cancer liver metastasis via ameliorating exosomal CCL2 primed pre-metastatic niche[J].J Ethnopharmacol,2019,238(3):16-28.
[36] 李晶晶,季 青,刘 煊,等.滋阴化痰方通过调控外泌体对小鼠胃癌的干预作用[J].国际中医中药杂志,2021,43(5):472-476.
[37] 冯小可,林贞妍,刘 璇,等.化痰消瘀方逆转胃癌前病变效果及对胃液外泌体miRNA表达的影响[J].现代中西医结合杂志,2021,30(9):936-939,970.
[38] 刘佳琴,罗 吉,李勇敏,等.健脾消癌方对结肠癌外泌体诱导HFL1活化成CAFs的影响[J].中国实验方剂学杂志,2020,26(22):40-46.
[39] Dang Y,Xu J,Zhu M,et al.Gan-Jiang-Ling-Zhu decoction alleviates hepatic steatosis in rats by the miR-138-5p/CPT1B axis[J].Biomed Pharmacother,2020,127(9):110-127.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年基金资助项目(81904128); 山东省博士后创新计划项目(202003069)
更新日期/Last Update: 2023-10-09