[1]车竹梅,张 芹,张 彤,等.五神针联合尼莫地平治疗老年中风后认知障碍肾精亏虚证疗效研究[J].陕西中医,2024,(3):407-410.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.028]
　CHE Zhumei,ZHANG Qin,ZHANG Tong,et al.Curative effect study on five mind points combined with nimodipine for treatment of Shenjing Kuixu syndrome of elderly cognitive impairment after stroke[J].,2024,(3):407-410.[doi:DOI:10.3969/j.issn.1000-7369.2024.03.028]
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五神针联合尼莫地平治疗老年中风后认知障碍肾精亏虚证疗效研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年3期
页码:
407-410
栏目:
针灸经络
出版日期:
2024-03-05

文章信息/Info

Title:
Curative effect study on five mind points combined with nimodipine for treatment of Shenjing Kuixu syndrome of elderly cognitive impairment after stroke
作者:
车竹梅1; 张 芹2; 张 彤1; 仇山波1
(1.扬州市中医院针灸科,江苏 扬州225127; 2.泰州市姜堰中医院康复科,江苏 泰州225599)
Author(s):
CHE Zhumei; ZHANG Qin; ZHANG Tong; QIU Shanbo
(Department of Acupuncture and Moxibustion,Yangzhou Hospital of Traditional Chinese Medicine,Yangzhou 225127,China)
关键词:
脑卒中;  五神针;  认知障碍;  血流动力学;  氧化应激
Keywords:
Stroke;  Five mind points;  Cognitive impairment;  Hemodynamics;  Oxidative stress efficacy
分类号:
R 255.2
DOI:
DOI:10.3969/j.issn.1000-7369.2024.03.028
文献标志码:
A
摘要:
目的:分析五神针联合尼莫地平对老年缺血性脑卒中后轻度认知障碍肾精亏虚证疗效。方法:老年中风后认知障碍患者122例,根据随机数字表法分为治疗组(n=61)、对照组(n=61)。两组中风后认知障碍患者依据指南行常规个体化方案,对照组服用尼莫地平片,治疗组于对照组基础上行五神针治疗。两组连续观察8周。比较两组认知障碍、日常生活活动能力、肾精亏虚证评分、临床疗效以及脑血流动力学、氧化应激损伤情况。结果:治疗组中风后认知障碍患者的总有效率93.44%高于对照组的80.33%,差异有统计学意义(P<0.05)。治疗8周后,两组简易智能量表、Barthel指数评分均升高,且治疗组高于对照组,差异有统计学意义(均P<0.05)。治疗8周后,两组肾精亏虚证评分减少,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗8周后,两组椎动脉、大脑中动脉阻力指数下降,且治疗组低于对照组,差异有统计学意义(均P<0.05)。治疗8周后,两组血清还原型谷胱甘肽水平升高,丙二醛下降,且治疗组上述指标改善更好,差异有统计学意义(均P<0.05)。结论:五神针治疗老年中风后认知障碍肾精亏虚证疗效较好,能有效改善患者认知障碍、日常生活活动能力、中医证候以及脑血流动力学,且能减轻氧化应激损伤。
Abstract:
Objective:To analyze efficacy of five mind points combined with nimodipine curative effect for Shenjing Kuixu syndrome of elderly cognitive impairment after stroke.Methods:122 elderly cognitive impairment after stroke were selected and divided into treatment group(n=61)and control group(n=61)according to random number table method.The two groups received routine individualized programs according to guidelines.The control group received nimodipine tablets,and the treatment group treated with five mind points on the basis of the control group.Both groups were observed for 8 weeks.Cognitive dysfunction,ability of daily living activities,score of syndrome of kidney essence deficiency,clinical efficacy,cerebral hemodynamics and oxidative stress injury were compared between the two groups.Results:The total effective rate of the treatment group 93.44%was higher than that in the control group 80.33%,difference statistically significant(P<0.05).After 8 weeks of treatment,scores of Mini-mental state examination and Barthel index were increased in the both groups,and more significantly in the treatment group,difference statistically significant(all P<0.05).After 8 weeks of treatment,scores of syndrome of kidney essence deficiency in the two groups were significantly decreased,and decrease more in the treatment group,difference statistically significant(P<0.05).After 8 weeks of treatment,the vertebral artery and middle cerebral artery resistance index decreased significantly in both groups,and decrease more significant in the treatment group,difference statistically significant(all P<0.05).After 8 weeks of treatment,serum level of glutathione was significantly increased and malondialdehyde level were significantly decreased in the two groups,and above indexes better improved in the treatment group,difference statistically significant(all P<0.05).Conclusion:The efficacy of five mind points on Shenjing Kuixu syndrome of elderly cognitive impairment after stroke,can effectively improve patients' cognitive impairment,ability of daily living activities,traditional Chinese medicine syndromes,improve cerebral hemodynamics,and reduce oxidative stress damage.

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备注/Memo

备注/Memo:
基金项目:江苏省科学技术厅基础研究项目(BK20200266)
更新日期/Last Update: 2024-03-08