[1]李牛牛,张俊立,刘亚军,等.基于“脑肠轴”探讨中药复方治疗胃食管反流病研究进展[J].陕西中医,2024,(4):570-573.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.031]
　LI Niuniu,ZHANG Junli,LIU Yajun,et al.Research progress in the treatment of gastroesophageal reflux disease with traditional Chinese medicine compound based on the “brain gut axis”[J].,2024,(4):570-573.[doi:DOI:10.3969/j.issn.1000-7369.2024.04.031]
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基于“脑肠轴”探讨中药复方治疗胃食管反流病研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年4期
页码:
570-573
栏目:
综 述
出版日期:
2024-04-05

文章信息/Info

Title:
Research progress in the treatment of gastroesophageal reflux disease with traditional Chinese medicine compound based on the “brain gut axis”
作者:
李牛牛1; 张俊立2; 刘亚军3; 郑瑾彤1(马来西亚); 赵 崧3
(1.南京中医药大学第一临床医学院,江苏 南京 210023; 2.南京中医药大学附属医院感染科,江苏 南京 210029; 3.南京中医药大学附属医院消化科,江苏 南京210029)
Author(s):
LI Niuniu; ZHANG Junli; LIU Yajun; ZHENG Jintong; ZHAO Song
(The First Clinical College of Nanjing University of Chinese Medicine,Nanjing 210023,China)
关键词:
胃食管反流病;  脑肠轴;  中药复方;  胃食管动力;  食管敏感性;  焦虑抑郁
Keywords:
Gastroesophageal reflux disease;  Brain gut axis;  Traditional Chinese medicine compound;  Gastroesophageal motility;  Esophageal sensitivity;  Anxiety and depression
分类号:
R 571
DOI:
DOI:10.3969/j.issn.1000-7369.2024.04.031
文献标志码:
A
摘要:
针对胃食管反流病(GERD),抑酸治疗为临床主要治疗措施,但尚不能充分缓解患者临床症状。中药具有多靶点、多通路、多层次的优势,可通过调节脑肠轴(BGA)上的多条通路,进而增强胃食管动力,降低内脏敏感性,改善不良情绪,维持免疫稳态,调控肠道菌群,从而发挥综合效应以治疗GERD。现系统阐述了BGA在GERD发病机制中起到的“神经-内分泌-免疫-微生物”网络桥接作用,并对中药复方从BGA的角度治疗GERD的机制进行系统分析与总结,以期为中医药防治GERD领域的研究人员提供思路和方向。
Abstract:
Acid suppression is the main method in gastroesophageal reflux disease(GERD)treatment,but the clinical symptoms can not be fully alleviated.Traditional Chinese medicine has shown the advantages of multi-target,multi-pathway and multi-level.It can enhance gastroesophageal motility,reduce visceral sensitivity,relieve adverse emotions,maintain immune homeostasis,and modify intestinal flora by regulating multiple pathways on the brain gut axis(BGA).Therefore,Traditional Chinese medicine exerts comprehensive effects in GERD treatments.This review systematically described the function of BGA in the pathogenesis of GERD as the “neuro-endocrino-immune-microbial” network bridging role.Moreover,it analyzed and summarized the mechanism of TCM compounds from the perspective of BGA,in order to provide novel ideas and directions for researchers in the field of TCM prevention and treatment of GERD.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81774243); 江苏省中医药管理局科技项目(JD2022SZ04)
更新日期/Last Update: 2024-04-10