[1]屈建敏,王 刚.手足综合征中医研究进展[J].陕西中医,2024,(10):1438-封3.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.033]
　QU Jianmin,WANG Gang.Progress of Chinese medicine research on hand-foot syndrome[J].,2024,(10):1438-封3.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.033]
点击复制

手足综合征中医研究进展
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年10期
页码:
1438-封3
栏目:
综 述
出版日期:
2024-10-05

文章信息/Info

Title:
Progress of Chinese medicine research on hand-foot syndrome
作者:
屈建敏1; 王 刚2
(1.陕西中医药大学,陕西 咸阳 712046; 2.陕西中医药大学第二附属医院,陕西 咸阳 712000)
Author(s):
QU Jianmin; WANG Gang
(Shaanxi University of Chinese Medicine,Xianyang 712046,China)
关键词:
恶性肿瘤;  手足综合征;  血痹;  研究进展;  辨证论治
Keywords:
Malignant tumor;  Hand-foot syndrome;  Blood paralysis;  Research progress;  Holistic diagnosis and treatment
分类号:
R 273
DOI:
DOI:10.3969/j.issn.1000-7369.2024.10.033
文献标志码:
A
摘要:
手足综合征(HFS)是恶性肿瘤治疗中常见的不良反应之一,随着抗肿瘤药物的广泛使用,其发病率逐渐升高。HFS严重影响患者日常社交、生活,甚至导致药物减量或提前停药,延误治疗。现代医学对其病因及发病机制认识尚未完全明确,疗效评价缺乏统一标准,且针对性系统治疗方法效果较差。中医学将HFS归属于“血痹”范畴,认为其病位在手足,以虚为主,本虚标实,虚实夹杂,治疗具有显著优势。现梳理近年来中医药治疗HFS相关文献,从病因病机和辨证论治方面总结中医药治疗现状,中医药临床将其分为内治法、外治法和内外合治法,以期为今后中医药治疗HFS提供临床依据和参考。
Abstract:
Hand-foot syndrome(HFS)is one of the common adverse reactions in the treatment of malignant tumors,and its incidence has gradually increased with the widespread use of antineoplastic drugs.HFS seriously affects patients' daily socialization and life,and even leads to drug dosage reduction or early discontinuation,delaying treatment.Modern medical knowledge of its etiology and pathogenesis is not yet completely clear,the evaluation of therapeutic efficacy lacks a unified standard,and the effect of targeted systemic treatment methods is poor.Chinese medicine classifies HFS under the category of “blood paralysis”,which is considered to be a disease of the hands and feet,with deficiency as the main cause,the underlying deficiency and the mixture of deficiency and reality,and the treatment has significant advantages.We now combed through the literature related to the treatment of HFS with Chinese medicine in recent years and summarized the current status of its treatment in terms of etiology,pathogenesis and evidence-based treatment,which was classified into internal,external and combined internal and external treatments,with a view to providing clinical bases and references for the treatment of HFS with Chinese medicine in the future.

参考文献/References:

[1] 席晨曦,强万敏,王书蕊,等.化学治疗引起的手足综合征管理现状及研究进展[J].护理与康复,2023,22(5):94-97.
[2] CHEN J,WANG Z.How to conduct integrated pharmaceutical care for patients with hand-foot syndrome associated with chemotherapeutic agents and targeted drugs[J].Journal of Oncology Pharmacy Practice,2021,27(4):919-929.
[3] 刘淑娟,王薇.紫杉类药物所致周围神经病变免疫炎症机制研究进展[J].陕西医学杂志,2022,51(4):511-513.
[4] TAKAHASHI Y,TAKEI Y,MACHIDA S,et al.Efficacy and toxicity of pegylated liposomal doxorubicin as therapy for recurrent ovarian cancer in relation to the number of previous chemotherapy regimens:Comparison with gemcitabine[J].Journal of Obstetrics and Gynaecology Research,2021,47(2):551-559.
[5] 曹绍华,王庆庆,张金冉.索拉非尼联合卡培他滨治疗肝细胞肝癌疗效及对患者血清miR-212和miR-132水平的影响[J].陕西医学杂志,2020,49(5):615-618.
[6] CHEN R,YANG L,HU S,et al.Apatinib plus 5-fluorouracil as a third or subsequent-line treatment option for metastatic colorectal cancer:A phase-Ⅱ,single-arm,prospective study[J].Annals of Translational Medicine,2022,10(2):100.
[7] ZHAO Y,SU W,LIANG G,et al.High dose and hepatobiliary dysfunction are associated with hand-foot syndrome in patients with lymphoma using pegylated liposomal doxorubicin:A retrospective study[J].BMC Pharmacology and Toxicology,2021,22(1):63.
[8] 胡圣涓,杨婕,孙韬.从《金匮要略》探讨骨髓抑制的中医辨治[J].陕西中医,2023,44(7):925-928.
[9] 裴育莹.抗癌药物所致手足综合征的中医分型及其相关因素分析[D].北京:北京中医药大学,2019.
[10] 贾立群,贾英杰,陈冬梅,等.手足综合征中医辨证分型及治法方药专家共识[J].中医杂志,2022,63(6):595-600.
[11] 赵高菲,王海龙.从瘀论治抗肿瘤药物相关手足综合征[J].基层中医药,2022,1(9):68-72.
[12] 郭勇.恶性肿瘤及并发症中西医结合治疗[M].北京:人民军医出版社,2014:230-233.
[13] 楚瑞阁,郑舞,梅丽俊,等.阿帕替尼所致手足综合征的中医证候分布特点研究[J].中国中医药现代远程教育,2023,21(17):57-59.
[14] 许博文,张潇潇,李杰,等.基于“诸湿肿满,皆属于脾”分级辨治手足综合征[J].辽宁中医杂志,2023,50(5):46-49.
[15] 韩莹莹,李杰,曹璐畅,等.基于玄府理论探讨手足综合征论治[J].天津中医药大学学报,2023,42(5):670-675.
[16] 陈晨.补阳还五汤对急性脑梗死患者血管内皮生长因子、血管生成素-2及神经功能影响的研究[J].陕西中医,2019,40(1):28-30.
[17] 孙杰.基于NF-κB/NLRP3信号通路探讨补阳还五汤对HUVECs炎症的保护作用[D].沈阳:辽宁中医药大学,2023.
[18] 霍晓克,贾彦焘.黄芪桂枝五物汤在肿瘤治疗的临床应用概况[J].中医肿瘤学杂志,2022,4(3):71-75.
[19] 周晓艳,徐基平.加味当归饮子治疗卡培他滨化疗后手足综合征疗效观察[J].中医临床研究,2022,14(16):111-114.
[20] 李韬芝,贾立群,邵文博,等.热毒蕴结型手足综合征临床论治经验撷菁[J].中日友好医院学报,2022,36(4):235-236.
[21] 宣立功,肖琳,姚蕾.安罗替尼对晚期非小细胞肺癌患者中医证型及演变特征的影响[J].中国临床研究,2021,34(7):950-953.
[22] 田佳月.中药膏方对使用安罗替尼肿瘤患者症状改善情况的临床研究[D].北京:北京中医药大学,2022.
[23] 闫玉.芩连解毒膏治疗卡培他滨所致手足综合征临床观察[D].张家口:河北北方学院,2022.
[24] 何倩.清热凉血通络膏治疗抗肿瘤药物所致气滞热瘀型手足综合征的临床观察[D].南京:南京中医药大学,2021.
[25] 李宁,王莹雪,刘赳,等.玉肤解毒膏治疗结直肠癌患者卡培他滨化疗所致手足综合征的疗效观察[J].现代生物医学进展,2023,23(7):1274-1278.
[26] 秦蔚然,焦智民,温艳艳,等.芩紫手足霜外涂治疗手足综合征临床疗效观察[J].实用中西医结合临床,2023,23(3):70-72.
[27] 吴春泉,吴衍伟,周文辉,等.如意金黄散治疗抗肿瘤药物之手足综合征临床研究[J].光明中医,2023,38(10):1903-1905.
[28] 王琪,梁惠.红花愈肤洗剂治疗卡培他滨导致结直肠癌患者手足综合征的临床疗效观察[J].中国处方药,2023,21(2):146-148.
[29] 王杨.活血通络方泡浴治疗抗癌药物相关手足综合征(气虚血瘀型)的临床观察[D].乌鲁木齐:新疆医科大学,2021.
[30] 毛晓峰,黄鋆文.黄芪桂枝五物汤加减中药功能性手套预防化疗相关手足综合征29例[J].浙江中医杂志,2023,58(9):663.
[31] 周玉球,韦炜,黄波,等.督脉灸联合中药泡洗及护理干预对卡培他滨相关性手足综合征的预防效果[J].当代护士(上旬刊),2022,29(5):89-91.

相似文献/References:

[1]万晓燕.芪术茯苓汤治疗恶性肿瘤化疗后白细胞减少临床研究[J].陕西中医,2019,(1):100.
　WAN Xiaoyan..Clinical study of Qizhu Fuling decoction in the treatment of malignant tumor after chemotherapy of white blood cell reduction[J].,2019,(10):100.
[2]任 伟,王巧云.参丹散结胶囊联合核磁共振引导下的高强度聚焦超声消融 治疗妇科恶性肿瘤骨转移临床研究*[J].陕西中医,2019,(5):648.
　REN Wei,WANG Qiaoyun..Effect of Danshen Sanjie capsule combined with magnetic resonance imaging guided high intensity focused ultrasound ablation in the treatment of gynecologic malignant tumor bone metastasis[J].,2019,(10):648.
[3]刘包欣子,金志超,邵 杰,等.王瑞平教授运用解毒散结对药治疗恶性肿瘤经验[J].陕西中医,2021,(11):1601.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.025]
　LIU Baoxinzi,JIN Zhichao,SHAO Jie,et al.Professor WANG Ruiping's experience in treating malignant tumors with paired detoxification and Sanjie herbs[J].,2021,(10):1601.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.025]
[4]简小兰,蒋益兰,蒋盛昶.蒋益兰教授治疗恶性肿瘤骨转移经验[J].陕西中医,2022,(5):620.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.018]
　JIAN Xiaolan,JIANG Yilan,JIANG Shengchang.Experiences from Professor JIANG Yilan in treating bone metastasis of malignant tumour[J].,2022,(10):620.[doi:DOI:10.3969/j.issn.1000-7369.2022.05.018]
[5]陈 玉,肖海娟,王惠玲,等.基于伏邪理论探讨恶性肿瘤发病机制[J].陕西中医,2022,(12):1760.[doi:DOI:10.3969/j.issn.1000-7369.2022.12.026]
[6]梁奡晟雄,周红光.温滋解毒法治疗恶性肿瘤理论探讨[J].陕西中医,2023,(7):913.[doi:DOI:10.3969/j.issn.1000-7369.2023.07.020]
[7]丁艳琦,郝皖蓉,冷玉玲,等.草灵丹加减联合温经浴袋改善恶性肿瘤患者高凝状态临床观察[J].陕西中医,2024,(5):646.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.016]
　DING Yanqi,HAO Wanrong,LENG Yuling,et al.Clinical efficacy of modified Caoling pill combined with warming meridian bath bag on improving hypercoagulable state in patients with malignant tumors[J].,2024,(10):646.[doi:DOI:10.3969/j.issn.1000-7369.2024.05.016]
[8]殷华芳,奚 蕾,沈卫东,等.名中医沈伟生基于“治未病”理念防治恶性肿瘤经验[J].陕西中医,2024,(10):1411.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.026]
　YIN Huafang,XI Lei,SHEN Weidong,et al.Shen Weisheng's experience in preventing and treating malignant tumors based on concept of “Preventive treatment of disease” theory[J].,2024,(10):1411.[doi:DOI:10.3969/j.issn.1000-7369.2024.10.026]

备注/Memo

备注/Memo:
基金项目:陕西省中医药管理局科研课题(2021-ZZ-LC006,2019-GJ-LC013); 西安市西咸新区名中医李彩霞传承工作室建设项目(202103); 秦都李氏药火针流派传承工作室建设项目[陕中医药发(2018)40号]
更新日期/Last Update: 2024-10-08