[1]陈 梅,陈 茜,党慧敏,等.补肾调经方联合脱氢表雄酮治疗卵巢储备功能减退临床研究[J].陕西中医,2025,46(2):188-191,196.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.008]
　CHEN Mei,CHEN Qian,DANG Huimin,et al.Clinical efficacy of Bushen Tiaojing formula combined with dehydroepiandrosterone in the treatment of diminished ovarian reservation patients[J].,2025,46(2):188-191,196.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.008]
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补肾调经方联合脱氢表雄酮治疗卵巢储备功能减退临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年2期
页码:
188-191,196
栏目:
临床研究
出版日期:
2025-02-05

文章信息/Info

Title:
Clinical efficacy of Bushen Tiaojing formula combined with dehydroepiandrosterone in the treatment of diminished ovarian reservation patients
作者:
陈 梅1; 陈 茜1; 党慧敏2; 李美和3; 刘艳巧2
(1.西安交通大学第一附属医院生殖医学科,陕西 西安 710061; 2.西安交通大学第二附属医院中医科,陕西 西安 710004; 3.西安交通大学第一附属医院肾脏移植科,陕西 西安 710061)
Author(s):
CHEN Mei1; CHEN Qian1; DANG Huimin2; LI Meihe3; LIU Yanqiao2
(1.Department of Reproductive Medicine,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China; 2.Department of Traditional Chinese Medicine,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China; 3.Department of Kidney Transplantation,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)
关键词:
卵巢储备功能减退;  补肾调经方;  脱氢表雄酮;  促卵泡生成素;  抗缪勒管激素
Keywords:
Diminished ovarian reservation;  Bushen Tiaojing formula;  Dehydroepiandrosterone;  Follicle-stimulating hormone;  Anti-Mullerian hormone
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2025.02.008
文献标志码:
A
摘要:
目的:探究自拟补肾调经方联合脱氢表雄酮(DHEA)治疗卵巢储备功能减退(DOR)的临床疗效。方法:选择74例观察期未进行激素补充治疗(HRT)的DOR患者,其中试验组40例予以补肾调经方联合DHEA治疗; 对照组34例予以DHEA治疗,疗程均为3个月经周期,比较两组患者的性激素(FSH、LH、E2、T)、抗缪勒管激素(AMH)、卵巢体积、基础窦卵泡(AFC)、改良Kupperman量表总积分及中医症状评分的变化。结果:试验组治疗后FSH明显低于治疗前及同期对照组(P<0.05),而LH、E2、T及AMH在两组间差异无统计学意义(P>0.05); 试验组治疗后AFC明显高于治疗前及同期对照组(P<0.05),而卵巢体积两组间差异无统计学意义(P>0.05); 试验组治疗后改良Kupperman量表总积分明显低于治疗前及同期对照组(P<0.05); 试验组治疗后部分中医症状评分明显低于治疗前及同期对照组(P<0.05)。结论:补肾调经方联合DHEA治疗DOR可获得满意疗效,明显优于单独DHEA治疗。
Abstract:
Objective:To observe the clinical efficacy of Bushen Tiaojing formula combined with dehydroepiandrosterone(DHEA)on the treatment of diminished ovarian reservation patients.Methods:A retrospective analysis was used,a total of 74 patients with diminished ovarian reservation(DOR)who refused hormone replacement therapy(HRT)were divided into two groups.The experimental group with 40 cases was treated with Bushen Tiaojing formula combined with DHEA,the control group with 34 cases was treated with DHEA,both groups were treated for 3 menstrual cycle.The hormone levels(FSH、LH、E2、T),the anti-Müllerian hormone(AMH),the changes of ovarian volume,the antral follicle counting(AFC),the improved Kupperman total score and the traditional Chinese medicine symptoms were compared in the two groups.Results:After treatment,the levels of FSH in experimental group were significantly lower than before treatment and the same period in the control group(P<0.05),the levels of LH,E2,T and AMH had no obvious difference between the two groups(P>0.05); the AFC in experimental group were significantly higher than before treatment and the same period in the control group(P<0.05),the changes of ovarian volume had no obvious difference between the two groups(P>0.05); the improved Kupperman total score in experimental group was significantly lower than the treatment before and the same period in the control group(P<0.05); the part of traditional Chinese medicine symptoms score in experimental group was significantly lower than the treatment before and the same period in the control group(P<0.05).Conclusion:Bushen Tiaojing formula combined with DHEA achieved remarkable curative effect in the treatment of DOR,which was better than DHEA therapy alone.

参考文献/References:

[1] PATRIZIO P,VAIARELLI A,LEVI SETTI P E,et al.How to define,diagnose and treat poor responders? Responses from a worldwide survey of IVF clinics[J].Reprod Biomed Online,2015,30(6):581-592.
[2] 韩玉芬,程淑蕊,敬文娜,等.卵巢储备功能减退的预测及治疗[J].中国计划生育学杂志,2017,18(2):117.
[3] MASSIMO T,MARIA V C,DOMENICO B,et al.Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old[J].Reproductive Biology and Endocrinology,2015,13:18.
[4] 田沛哲,李蕾,范英英,等.卵巢储备功能减退的研究进展[J].中华实用诊断与治疗杂志,2021,35(7):4.
[5] 张吟,徐小凤.卵巢储备功能下降的病因病机初探[J].黑龙江中医药,2009,12(4):3-4.
[6] 庞爱凤,王佩娟,卢燕.补肾活血法治疗应激导致卵巢功能减退[J].长春中医药大学学报,2013,22(6):3.
[7] FERRARETTI A P,MARCA A L,FAUSER B C,et al.ESHRE consensus on the definition of “poor response” to ovarian stimulation for in vitro fertilization:The Bologna criteria[J].Human Reproduction,2011,26(7):1616-1624.
[8] 曹泽毅.中华妇产科学(下册)[M].北京:人民卫生出版社,1999:2281.
[9] 国家中医药管理局.24个专业104个病种中医诊疗方案(试行)[M].北京:国家中医药管理局医政司,2012:43.
[10] 周均霞,贺春,赵玲玲,等.多囊卵巢综合征合并亚临床甲状腺功能减退患者的内分泌特征[J].河北医药,2023,45(3):427-429.
[11] 胡淑玲,王韫琪,田丹.温经汤加减治疗肾虚血瘀型卵巢储备功能减退疗效及对患者子宫动脉血流和卵巢功能的影响[J].陕西中医,2023,44(10):1395-1399.
[12] 康华,马建新,王旭初,等.疏肝滋肾方治疗肝郁肾虚型卵巢储备功能减退临床研究[J].河北中医,2023,45(10):1627-1630,1634.
[13] 郁琦.早发性卵巢功能不全诊治进展[J].中国实用妇科与产科杂志,2018,34(3):241-242.
[14] 孙海翔,丁利军.卵巢衰老的临床干预新进展[J].生殖医学杂志,2018,27(3):199-213.
[15] 王悦竹,刘雁峰,曹一鸣,等.补肾疏肝方治疗卵巢储备功能减退70例临床观察[J].中华中医药杂志,2020,35(11):5883-5886.
[16] 薛红梅,金萍,李孟邻,等.李月梅“通元针法”辅助卵巢储备功能下降患者IVF-ET经验[J].中医学报,2020,35(6):125-128.
[17] 邱美江,谢秀梅.加味四物二仙汤治疗卵巢储备功能减退临床研究[J].陕西中医,2022,42(7):860-862.
[18] 江华峰,孙晓溪.脱氢表雄酮(DHEA)在卵巢储备功能低下妇女中的应用进展[J].生殖与避孕,2020,34(4):306-310.
[19] TARTAGNI M,CICINELLI M V,BALDINI D,et al.Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in woman younger than 40 years old[J].Reprod Biol Endocrinol,2015,13:18.
[20] GAT I,BLANCO M S,BALAKIER H,et al.The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve[J].Gynecol Endocrinol,2016,32:534-537.
[21] 刘亚娟,赵俐.卵巢储备功能下降的中医病因病机和治疗研究进展[J].江西中医药,2022,53(12):4.
[22] 王如芯,谈勇,胡溢清.谈勇治疗卵巢储备功能减退经验探析[J].中医药临床杂志,2021,33(6):1060-1063.
[23] 范美玲,杨攀,吴小燕,等.针灸治疗卵巢早衰疗效的Meta分析[J].云南中医学院学报,2018,41(6):63-69.
[24] 薛春.中医针药联合5E康复管理模式对腹腔镜全子宫切除患者卵巢功能的影响[J].长春中医药大学报,2020,36(6):4.
[25] 陈思达,梁雪芳,刘永波,等.国医大师刘敏如辨治经水早断诸证(卵巢功能减退性疾病)经验[J].吉林中医药,2024,44(2):170-173.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金青年科学基金资助项目(81703797); 国家中医药管理局项目[国中医药人教函(2022)75号]
更新日期/Last Update: 2025-02-08