[1]汪 静,李佩芳,高晓明,等.石冰醒脑丸联合电针治疗血管性痴呆疗效观察[J].陕西中医,2025,46(4):559-563.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.027]
　WANG Jing,LI Peifang,GAO Xiaoming,et al.Therapeutic efficacy of Shibing Xingnao pill combined with electroacupuncture in the treatment of vascular dementia[J].,2025,46(4):559-563.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.027]
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石冰醒脑丸联合电针治疗血管性痴呆疗效观察
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年4期
页码:
559-563
栏目:
针灸经络
出版日期:
2025-04-20

文章信息/Info

Title:
Therapeutic efficacy of Shibing Xingnao pill combined with electroacupuncture in the treatment of vascular dementia
作者:
汪 静; 李佩芳; 高晓明; 浦 芳; 刘 霞; 韦晓丽
(安徽中医药大学第二附属医院,安徽 合肥 230061)
Author(s):
WANG Jing; LI Peifang; GAO Xiaoming; PU Fang; LIU Xia; WEI Xiaoli
(The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230061,China)
关键词:
血管性痴呆;  石冰醒脑丸;  认知功能;  电针;  神经营养因子;  脑血流量
Keywords:
Vascular dementia;  Shibing Xingnao pill;  Cognitive function;  Electroacupuncture;  Neurotrophic factors;  Cerebral blood flow
分类号:
R 749.1
DOI:
DOI:10.3969/j.issn.1000-7369.2025.04.027
文献标志码:
A
摘要:
目的:观察石冰醒脑丸联合电针治疗血管性痴呆的临床疗效。方法:选取64例血管性痴呆的患者,按照随机数字表法分为电针组和联合组各32例,其中电针组脱失1例。电针组单纯进行电针治疗,1次/d,每周治疗6 d; 联合组在电针组的基础上联合石冰醒脑丸口服治疗,两组均连续治疗4周。分别在治疗前及治疗1周后观察两组患者中医证候积分、认知功能水平(MMSE评分)、日常生活能力(ADL评分)、大脑前动脉(ACA)、大脑中动脉(MCA)以及大脑后动脉(PCA)的血流速度、血清中枢神经特异性蛋白β(S-100β)、神经元特异性烯醇化酶(NSE)、神经生长因子(NGF)水平以及临床疗效的差异。结果:治疗后两组患者中医证候积分、血清S-100β以及NSE水平降低,且联合组低于对照组(均P<0.05); 治疗后两组患者MMSE评分、ADL评分、ACA、MCA、PCA血流量及血清NGF水平升高,且联合组高于对照组(均P<0.05); 联合组总有效率90.63%,高于对照组的74.19%(P<0.05)。结论:石冰醒脑丸联合电针能够显著提高VD患者的脑血流量,改善患者的血清神经因子水平,改善认知功能及生活能力水平,临床疗效显著。
Abstract:
Objective:To observe the clinical efficacy of Shibing Xingnao pill combined with electroacupuncture in treating vascular dementia.Methods:A total of 64 patients with vascular dementia were included,who were divided into either electroacupuncture group or combination group according to a random number table,each group was consist of 32 cases.One case was lost in electroacupuncture group.The electroacupuncture group was treated with electroacupuncture only once a day for 6 days per week.Combined group was treated with Shibing Xingnao pill orally on the basis of electroacupuncture group,and both groups were treated continuously for 4 weeks.Before treatment and after one week of treatment,the traditional Chinese medicine syndrome score,cognitive function level(MMSE score),ability of daily living(ADL score),blood flow velocity of anterior cerebral artery(ACA),middle cerebral artery(MCA),and posterior cerebral artery(PCA),serum levels of S-100β,NSE,NGF,and clinical efficacy differences between the two groups were observed.Results:After treatment,both groups showed a decrease in TCM syndrome scores,serum S-100β,and NSE levels,with the combination group having lower levels than the control group(all P<0.05).Additionally,after treatment,both groups exhibited increased MMSE scores,ADL scores,and cerebral blood flow in the ACA,MCA,and PCA,as well as elevated serum NGF levels,with the combination group surpassing the control group(all P<0.05).The overall effectiveness rate was 90.63% in the combination group,which was higher than the 74.19% in the control group(P<0.05).Conclusion:Shibing Xingnao pill combined with electroacupuncture can significantly improve the cerebral blood flow of VD patients,improve the serum neurotrophic factor levels,enhance cognitive function and ability of daily living,with significant clinical efficacy.

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备注/Memo

备注/Memo:
[基金项目]安徽省中医药传承创新科研项目(2022CCZD05); 安徽省高等学校科研计划项目(2024AH051015); 安徽中医药大学自然科学研究项目(2021EFYLC35)
更新日期/Last Update: 2025-04-08