[1]赵德敏,梁锦铃,高玖妹,等.中医药调控JAK2/STAT3信号通路治疗子宫内膜异位症研究进展[J].陕西中医,2025,46(4):568-571,576.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.029]
　ZHAO Demin,LIANG Jinling,GAO Jiumei,et al.Research progress on the regulation of JAK2/STAT3 signaling pathway by traditional Chinese medicine in the treatment of endometriosis[J].,2025,46(4):568-571,576.[doi:DOI:10.3969/j.issn.1000-7369.2025.04.029]
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中医药调控JAK2/STAT3信号通路治疗子宫内膜异位症研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年4期
页码:
568-571,576
栏目:
综 述
出版日期:
2025-04-20

文章信息/Info

Title:
Research progress on the regulation of JAK2/STAT3 signaling pathway by traditional Chinese medicine in the treatment of endometriosis
作者:
赵德敏1; 梁锦铃1; 高玖妹1; 张 新1; 孙 淼2; 马 明2; 徐 芳2
(1.黑龙江中医药大学,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040)
Author(s):
ZHAO Demin1; LIANG Jinling1; GAO Jiumei1; ZHANG Xin1; SUN Miao2; MA Ming2; XU Fang2
(1.Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China; 2.The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)
关键词:
子宫内膜异位症;  JAK2/STAT3信号通路;  中药单体;  中药复方;  针刺;  炎症反应
Keywords:
Endometriosis;  JAK2/STAT3 signaling pathway;  Chinese medicine monomer;  Chinese herbal compound;  Acupuncture;  Inflammatory response
分类号:
R 711.71
DOI:
DOI:10.3969/j.issn.1000-7369.2025.04.029
文献标志码:
A
摘要:
综述中医药调控Janus蛋白酪氨酸激酶2(JAK2)/信号转导和转录活因子3(STAT3)通路干预子宫内膜异位症(EMT)机制的进展。EMT异位内膜细胞的增殖、迁移和侵袭等可能与JAK2/STAT3通路有关。JAK2/STAT3通路的异常活化状态表现为EMT免疫失调、血管新生和炎症反应上调,介导异位内膜细胞的黏附-侵袭-血管形成。中药治疗EMT可通过抑制JAK2/STAT3信号通路调控包括JAK2、STAT3、肿瘤坏死因子-α、白细胞介素-17和血管内皮生长因子等靶基因的表达,调控机体异常免疫应答,抑制血管新生,减轻炎症反应。
Abstract:
To review the progress of Chinese medicine to modulate the mechanism of Janus protein tyrosine kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)pathway to intervene in endometriosis(EMT).Proliferation,migration,and invasion of ectopic endothelial cells of EMT may be related to the JAK2/STAT3 pathway.The aberrant activated state of the JAK2/STAT3 pathway manifests itself as EMT immune dysregulation,neovascularization,and upregulation of inflammatory responses mediate the adhesion-invasion-angiogenesis of ectopic endothelial cells.Traditional Chinese medicine treatment of EMT can regulate the abnormal immune response,inhibit neovascularization,and attenuate the inflammatory response by inhibiting the expression of target genes including JAK2,STAT3,tumor necrosis factor-α(TNF-α),interleukin-17(IL-17),and vascular endothelial growth factor(VEGF)through the inhibition of the JAK2/STAT3 signaling pathway.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助面上项目(82174195); 国家自然科学基金青年基金资助项目(82004401); 黑龙江省自然科学基金资助项目(LH2023H061); 黑龙江省中医药科研项目(ZHY2023-018)
更新日期/Last Update: 2025-04-08