[1]高 含,付宝慧,孙天昊,等.基于SIRT1信号通路探讨中医药治疗膜性肾病作用机制[J].陕西中医,2025,46(5):707-711.[doi:DOI:10.3969/j.issn.1000-7369.2025.05.029]
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基于SIRT1信号通路探讨中医药治疗膜性肾病作用机制
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年5期
页码:
707-711
栏目:
综 述
出版日期:
2025-05-05

文章信息/Info

作者:
高 含12付宝慧12孙天昊12吴若曦12杨洪涛12
(1.天津中医药大学第一附属医院,天津 300381; 2.国家中医针灸临床医学研究中心,天津 300381)
关键词:
膜性肾病 沉默信息调节因子 通路 中医药 足细胞 作用机制
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7369.2025.05.029
文献标志码:
A
摘要:
膜性肾病(MN)是成人肾病综合征最常见的病因之一,对肾脏健康构成严重威胁。在过去的十年间,MN患者数量显著增加。现在临床上治疗MN主要使用的药物是细胞毒素类,激素类以及免疫抑制的药品,这些药物具有一定的副作用,产生不良反应还会引起复发,所以寻求更好的治疗靶点找到更好的治疗策略很重要。SIRT1作为一个MN中的关键靶点发挥巨大的作用,在治疗足细胞损伤,参与氧化应激的方面,起到了至关重要的作用。中医药在MN治疗中显示出潜力,但基于SIRT1信号通路的中医药作用机制研究仍面临诸多挑战。临床研究受限于样本量小和观察时间短,难以准确评估中医药的疗效与安全性。未来研究需利用现代分子生物学技术,如基因编辑、蛋白质组学等,深入探究中医药成分对SIRT1信号通路的作用靶点与分子机制。同时,建立标准化的中医药研究体系,并开展多中心、大样本、长期临床研究,以全面揭示基于SIRT1信号通路的中医药治疗MN的作用机制,为MN的中医药防治提供更科学的依据和有效策略。本研究将立足于SIRT1信号通路,介绍中医药在防治MN方面的最新研究进展,旨在为MN的中医药临床诊治及有关研究提供思路。

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(82274441)
更新日期/Last Update: 2025-05-08