[1]符芸瑜,武素,谢媛.健脾渗湿解毒汤治疗尿酸性肾病湿热蕴结证临床研究[J].陕西中医,2025,46(6):766-770.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.009]
　FU Yunyu,WU Su,XIE Yuan.Clinical efficacy of Jianpi Shenshi Jiedu decoction in treating uric acid nephropathy with damp heat accumulation syndrome[J].,2025,46(6):766-770.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.009]
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健脾渗湿解毒汤治疗尿酸性肾病湿热蕴结证临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
766-770
栏目:
临床研究
出版日期:
2025-06-05

文章信息/Info

Title:
Clinical efficacy of Jianpi Shenshi Jiedu decoction in treating uric acid nephropathy with damp heat accumulation syndrome
作者:
符芸瑜; 武素; 谢媛
（广东省中医院海南医院 海南省中医院，海南 海口 570203）
Author(s):
FU Yunyu; WU Su; XIE Yuan
（Guangdong Provincial Hospital of Chinese Medicine,Hainan Hospital/Hainan Traditional Chinese Medicine Hospital，Haikou 570203,China）
关键词:
尿酸性肾病; 湿热蕴结证; 健脾渗湿解毒汤; 转化生长因子-β1; 炎性因子; 肾损伤分子-1; 肾功能; 氧化应激
Keywords:
Urinary acid nephropathy; Damp heat accumulation syndrome; Jianpi Shenshi Jiedu decoction; Transforming growth factor-β1; Inflammatory factors; Kidney injury molecule-1; Renal function; Oxidative stress
分类号:
R 692
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.009
文献标志码:
A
摘要:
目的：探讨健脾渗湿解毒汤治疗尿酸性肾病湿热蕴结证临床疗效，比较其对炎性因子及肾功能指标的影响。方法：选取确诊为尿酸性肾病的患者168例，中医证候属于湿热蕴结证。随机分为对照组和观察组各84例，对照组采用西医常规治疗，观察组采用西药联合健脾渗湿解毒汤治疗，两组均治疗28 d。结果：治疗后两组血清白介素-6（IL-6）、丙二醛（MDA）、转化生长因子-β1（TGF-β1）、白介素-1β（IL-1β）及尿肾损伤分子-1(KIM-1)降低，总抗氧化能力（TAOC）升高，组间结果比较，观察组上述实验室指标改善更显著（P<0.05）；肾功能方面，治疗后两组患者血尿酸（SUA）、肌酐（Scr）降低，内生肌酐清除率（CCr）升高，组间结果比较，观察组改善更显著（P<0.05）；观察组总有效率90.48%，高于对照组的73.81%（P<0.05）。结论：应用健脾渗湿解毒汤治疗尿酸性肾病湿热蕴结证患者可抑制炎性因子分泌，降低氧化应激损伤，改善肾功能，提高疗效。
Abstract:
Objective:To explore the clinical efficacy of Jianpi Shenshi Jiedu decoction in the treatment of urinary acidic nephropathy with damp heat accumulation syndrome,and to compare its effects on inflammatory factors and renal function indicators.Methods:A total of 168 patients diagnosed with uric acid nephropathy were selected,and the traditional Chinese medicine syndrome belongs to damp heat accumulation syndrome.Randomly divided into a control group and an observation group,with 84 cases in each group.The control group received conventional Western medicine treatment,while the observation group received a combination of Western medicine and Jianpi Shenshi Jiedu decoction treatment.Both groups were treated for 28 days.Results:After treatment,the levels of serum interleukin-6 (IL-6),malondialdehyde (MDA),transforming growth factor-β1(TGF-β1),interleukin-1β (IL-1β),and urinary kidney injury molecule-1 (KIM-1) decreased in both groups,while the total antioxidant capacity (TAOC) increased.Comparing the results between the groups,the observation group showed more significant improvement in the above laboratory indicators (P<0.05).In terms of renal function,after treatment,the serum uric acid (SUA) and creatinine of the two groups of patients decreased,and the endogenous creatinine clearance rate (CCr) increased.The results between the groups were compared,and the observation group showed more significant improvement (P<0.05).The total effective rate of the observation group was 90.48%,which was higher than the 73.81% of the control group (P<0.05).Conclusion:The application of Jianpi Shenshi Jiedu decoction in the treatment of patients with urinary acidic nephropathy with damp heat accumulation syndrome can inhibit the secretion of inflammatory factors,reduce oxidative stress damage,improve renal function,and enhance therapeutic efficacy.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82460907）；国家中医药管理局高水平中医药重点学科中医老年医学建设项目[琼卫中医函(2023)3号]
更新日期/Last Update: 2025-06-09