[1]陈广林,刘立俊,冯婷婷,等.温肾健脾方治疗绝经后骨质疏松性椎体骨折临床研究[J].陕西中医,2025,46(6):771-775.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.010]
　CHEN Guanglin,LIU Lijun,FENG Tingting,et al.Clinical study on postmenopausal osteoporotic vertebral fractures treated with Wenshen Jianpi decoction[J].,2025,46(6):771-775.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.010]
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温肾健脾方治疗绝经后骨质疏松性椎体骨折临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
771-775
栏目:
临床研究
出版日期:
2025-06-05

文章信息/Info

Title:
Clinical study on postmenopausal osteoporotic vertebral fractures treated with Wenshen Jianpi decoction
作者:
陈广林1; 刘立俊1; 2; 冯婷婷1; 任维龙1; 牛淑亮3; 马勇4; 郭杨4; KABYLSERIK Aibota3（哈萨克斯坦）; 于龙潭1
（1.潍坊市中医院，山东 潍坊261041；2.山东中医药大学第一临床医学院，山东 济南250199；3.新疆医科大学，新疆 乌鲁木齐830054；4.南京中医药大学附属医院，江苏 南京210029）
Author(s):
CHEN Guanglin1; LIU Lijun1; 2; FENG Tingting1; REN Weilong1; NIU Shuliang3; MA Yong4; GUO Yang4; KABYLSERIK Aibota3; YU Longtan1
(1.Weifang Hospital of Traditional Chinese Medicine,Weifang 261041,China;2.First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250199,China;3.Xinjiang Medical University,Urumqi 830054,China;4.Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029,China)
关键词:
绝经后骨质疏松症; 温肾健脾方; 椎体骨折; 骨密度; 骨转换标志物
Keywords:
Postmenopausal osteoporosis; Wenshen Jianpi decoction; Vertebral fractures; Bone mineral density; Bone turnover markers
分类号:
R 681
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.010
文献标志码:
A
摘要:
目的：探讨温肾健脾方对绝经后骨质疏松性椎体骨折患者的临床疗效及作用机制。方法：选取因绝经后骨质疏松性椎体骨折行PKP手术的患者57例，分为两组。对照组常规抗骨质疏松治疗，治疗组在此基础上加用温肾健脾方。分别于术前、术后6个月记录患者骨密度、Ⅰ型前胶原氨基末端肽（PⅠNP）、Ⅰ型胶原β-C-末端端肽(β-CTX)、铁蛋白、疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)，于术后3个月额外记录1次VAS、ODI。并在治疗结束后分析骨密度与β-CTX、PⅠNP、铁蛋白的相关性。结果：与术前比较，两组术后3个月的VAS、ODI显著好转，术后6个月各指标均显著好转（P＜0.05），且术后6个月VAS、ODI优于术后3个月（P＜0.05）。术前两组各指标比较差异无统计学意义（P＞0.05）；术后3个月，治疗组VAS、ODI明显优于对照组（P＜0.05）；术后6个月，治疗组骨密度、β-CTX、PⅠNP、铁蛋白、VAS、ODI均优于对照组（P＜0.05）。PⅠNP、β-CTX、铁蛋白与骨密度呈负相关，且三者存在正相关关系。结论：温肾健脾方能够显著提升绝经后骨质疏松症（PMOP）患者骨密度，对β-CTX、PⅠNP等关键骨代谢指标，以及铁蛋白的表达具有显著的改善作用。
Abstract:
Objective:To explore the clinical efficacy and mechanism of action of Wenshen Jianpi decoction in postmenopausal osteoporotic vertebral fracture patients.Methods:Fifty-seven patients with postmenopausal osteoporotic vertebral fractures who underwent PKP were divided into two groups.The control group received conventional anti-osteoporosis treatment,while the treatment group received Wenshen Jianpi decoction in addition to conventional treatment.Bone density,procollagen type Ⅰ N-terminal propeptide (PⅠNP),β-C-terminal telopeptide of type Ⅰ collagen (β-CTX),ferritin,Visual Analog Scale (VAS),and Oswestry Disability Index (ODI) were recorded before surgery and at 6 months postoperatively.VAS and ODI were additionally recorded at 3 months postoperatively.The correlation between bone density and β-CTX,PⅠNP,and ferritin was analyzed after treatment.Results:Compared with preoperative values,VAS and ODI scores in both groups improved significantly at 3 months postoperatively,and all indicators improved significantly at 6 months postoperatively (P<0.05).The 6 month postoperative VAS and ODI scores were better than those at 3 months postoperatively (P<0.05).There were no significant differences in preoperative indicators between the two groups (P>0.05).At 3 months postoperatively,the treatment group had significantly better VAS and ODI scores than the control group (P<0.05).At 6 months postoperatively,the treatment group had significantly better bone density,β-CTX,PⅠNP,ferritin,VAS,and ODI scores than the control group (P<0.05).PⅠNP,β-CTX,and ferritin were negatively correlated with bone density and positively correlated with each other.Conclusion:Wenshen Jianpi decoction can significantly increase bone density in postmenopausal osteoporosis (PMOP) patients and improve key bone metabolism indicators such as β-CTX and PⅠNP,as well as ferritin levels.

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备注/Memo

备注/Memo:
国家自然科学基金资助面上项目（81473692）；山东省中医药科技项目（ZR20240719）；山东省潍坊市卫生健康委员会科研项目（2022W022863）；山东省潍坊市科技发展计划项目（2021YX021,2023YX018）
更新日期/Last Update: 2025-06-09