[1]唐运媛,林奕,吴东升,等.加味芍药汤联合艾灸对湿热型溃疡性结肠炎患者外周血中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值的影响[J].陕西中医,2025,46(6):782-786.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.012]
　TANG Yunyuan,LIN Yi,WU Dongsheng,et al.Effects of modified Shaoyao decoction combined with moxibustion on peripheral blood neutrophil to lymphocyte ratio and platelet to lymphocyteratio in patients with ulcerative colitis of dampness-heat type[J].,2025,46(6):782-786.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.012]
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加味芍药汤联合艾灸对湿热型溃疡性结肠炎患者外周血中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
782-786
栏目:
临床研究
出版日期:
2025-06-05

文章信息/Info

Title:
Effects of modified Shaoyao decoction combined with moxibustion on peripheral blood neutrophil to lymphocyte ratio and platelet to lymphocyteratio in patients with ulcerative colitis of dampness-heat type
作者:
唐运媛1; 2; 林奕1; 吴东升1; 余艳兰1; 2
（1.湖南中医药大学第一附属医院肛肠科，湖南 长沙 410007；2.湖南中医药大学，湖南 长沙 410208）
Author(s):
TANG Yunyuan1; 2; LIN Yi1; WU Dongsheng1; YU Yanlan1; 2
（1.Department of Proctology,the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China;2.Hunan University of Chinese Medicine,Changsha 410208,China）
关键词:
溃疡性结肠炎; 加味芍药汤; 络病学说; 艾灸; 中性粒细胞与淋巴细胞比值; 血小板与淋巴细胞比值
Keywords:
Ulcerative colitis; Modified Shaoyao decoction; Collateral disease theory; Moxibustion; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio
分类号:
R 574.6
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.012
文献标志码:
A
摘要:
目的：“络病学说”指导艾灸联合加味芍药汤对（湿热型）溃疡性结肠炎（UC）患者外周血中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）的影响。方法：选取UC患者100例为研究对象，按随机数字表法分为对照组与研究组，各50例。对照组接受美沙拉秦，研究组在对照组基础上采用加味芍药汤联合艾灸治疗。比较两组临床效果及中医症候积分、血常规(NLR、PLR)水平、肠道黏膜屏障功能[二胺氧化酶（DAO）、D-乳酸（D-LA）和内毒素（ET）]。结果：治疗后两组总有效率比较，研究组（90.00%）高于对照组(70.00%,P＜0.05）；治疗后，中医症候积分比较两组均有所降低，且研究组低于对照组（P＜0.05）；治疗后，NLR、PLR水平比较，两组有所下降，且研究组低于对照组（P＜0.05）；治疗后，DAO、D-LA和ET水平比较，两组有所下降，且研究组低于对照组（P＜0.05）；两组不良反应发生率比较差异无统计学意义（P>0.05）。结论：“络病学说”指导艾灸联合加味芍药汤可有效减轻UC（湿热型）患者临床症状，提高治疗效果，降低炎症水平。
Abstract:
Objective:To explore the effects of moxibustion combined with modified Shaoyao decoction on peripheral blood neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with ulcerative colitis (UC,dampness-heat type) based on collateral disease theory.Methods:According to random number table method,100 patients with UC were divided into control group (n=50,mesalazine) and study group (n=50,modified Shaoyao decoction combined with moxibustion on basis of control group).The clinical effect,scores of TCM symptoms,blood routine (NLR,PLR) and intestinal mucosal barrier function [diamine oxidase (DAO),D-lactic acid (D-LA),endotoxin (ET)] in the two groups were compared.Results:After treatment,total response rate was higher in study group (90.00%) than control group (70.00%,P<0.05).After treatment,scores of TCM symptoms were decreased in both groups,which were lower in study group (P<0.05).After treatment,NLR and PLR were decreased in both groups,which were lower in study group (P<0.05).After treatment,levels of DAO,D-LA and ET were decreased in both groups,which were lower in study group (P<0.05).The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05).Conclusion:Moxibustion based on collateral disease theory combined with modified Shaoyao decoction can effectively relieve clinical symptoms,improve curative effect and reduce inflammation level in patients with UC (dampness-heat type).

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备注/Memo

备注/Memo:
湖南省卫生健康委员会科研立项课题（202204134275）
更新日期/Last Update: 2025-06-09