[1]崔志洁,高铸烨,姜众会,等.基于“脾主肌肉”理论探讨线粒体质量控制在心力衰竭合并肌少症中医药治疗中的价值[J].陕西中医,2025,46(6):795-799.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.015]
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基于“脾主肌肉”理论探讨线粒体质量控制在心力衰竭合并肌少症中医药治疗中的价值
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
795-799
栏目:
学术探讨
出版日期:
2025-06-05

文章信息/Info

作者:
崔志洁1高铸烨1姜众会1陈一帆1欧阳嘉慧1马丹2赵伶俐1杜天依3
(1.中国中医科学院西苑医院,北京100091;2.西苑医院苏州医院,江苏 苏州 215009;3.中国航天科工集团七三一医院,北京 100143)
关键词:
心力衰竭脾主肌肉线粒体质量控制肌少症线粒体动力学线粒体自噬
分类号:
R 541.6
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.015
文献标志码:
A
摘要:
心力衰竭是各类心血管疾病发展到终末期的临床综合征,心衰时肥大的心肌缺乏作为全身“泵”应有的力量,常易合并肌少症。肌少症是指与年龄相关的全身肌量减少和/或肌力下降或肌肉生理功能减退的一组临床综合征。线粒体质量控制通过协调生物发生、线粒体动力学(即线粒体裂变及融合)、线粒体自噬等过程来共同调控维持线粒体稳态。脾为“后天之本”,脾运化生成水谷精微,“脾主身之肌肉”,通过脾主升清的生理功能,升腾宣发清阳,输布精微物质于四肢,营养肌肉,肌肉活动轻盈有力。现代临床及动物实验等研究发现,“脾主肌肉失调”是心衰及肌少症的关键病因病机之一,也是线粒体质量控制相关功能紊乱这一病理机制的重要宏观表达。本文立足于“脾主肌肉”理论,探讨线粒体质量控制在心衰合并肌少症中的重要作用及中医药治疗的潜在优势。

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82274508);中国中医科学院科技创新工程重大攻关项目“心血管病中医健康状态监测预警与防控模式示范研究”(CI2021A00920);国家中医药传承创新团队项目(ZYYCXTD-C-202007)
更新日期/Last Update: 2025-06-09