[1]曾美琪,陈亚玲,许静,等.通督益脑针法联合补阳还五汤治疗血管性认知障碍疗效研究[J].陕西中医,2025,46(7):979-982,1001.[doi:DOI:10.3969/j.issn.1000-7369.2025.07.023]
　ZENG Meiqi,CHEN Yaling,XU Jing,et al.Effect study on Tongdu Yinao acupuncture combined with Buyang Huanwu decoction in treatment of vascular cognitive impairment[J].,2025,46(7):979-982,1001.[doi:DOI:10.3969/j.issn.1000-7369.2025.07.023]
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通督益脑针法联合补阳还五汤治疗血管性认知障碍疗效研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年7期
页码:
979-982,1001
栏目:
针灸经络
出版日期:
2025-07-05

文章信息/Info

Title:
Effect study on Tongdu Yinao acupuncture combined with Buyang Huanwu decoction in treatment of vascular cognitive impairment
作者:
曾美琪; 陈亚玲; 许静; 罗颖慧; 周文娟
（湖南中医药大学第一附属医院，湖南 长沙 410007）
Author(s):
ZENG Meiqi; CHEN Yaling; XU Jing; LUO Yinghui; ZHOU Wenjuan
（The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China）
关键词:
血管性认知障碍; 通督益脑针法; 补阳还五汤; 认知功能; 生活自理能力; 血流动力学; 中医证候积分
Keywords:
Vascular cognitive impairment; Tongdu Yinao acupuncture; Buyang Huanwu decoction; Cognitive function; Activity of daily living; Hemodynamics; TCM syndrome score
分类号:
R 245.31
DOI:
DOI:10.3969/j.issn.1000-7369.2025.07.023
文献标志码:
A
摘要:
目的：探讨通督益脑针法联合补阳还五汤治疗血管性认知障碍（VCI）疗效。方法：采用前瞻性随机对照研究方法，将103例VCI患者根据信封法随机分为两组，对照组51例、针药组52例。对照组在对症治疗基础上予以补阳还五汤治疗；针药组在对照组基础上，另予通督益脑针法治疗。比较两组患者治疗前后同型半胱氨酸（Hcy）、神经元特异性烯醇化酶（NSE）、血管内皮生长因子（VEGF）水平、大脑前动脉（ACA）和大脑中动脉（MAC）的平均血流速度（Vm）、蒙特利尔认知评估量表（MoCA）评分、简易精神状态检查量表（MMSE）评分、日常生活能力量表（ADL）评分、中医证候积分、临床疗效、不良反应。结果：治疗后，两组患者的Hcy、NSE水平均低于治疗前，VEGF水平高于治疗前，且针药组的变化幅度大于对照组（均P＜0.05）。治疗后，两组患者的ACA、MAC的Vm均优于治疗前，且针药组优于对照组（均P＜0.05）。治疗后，两组患者的MoCA、MMSE及ADL评分高于治疗前，且针药组高于对照组（均P＜0.05）。治疗后，两组患者的主证、次证和总积分低于治疗前，且针药组低于对照组（均P＜0.05）。针药组的临床疗效总有效率高于对照组（P＜0.05）。两组不良反应经比较，差异无统计学意义（P＞0.05）。结论：通督益脑针法联合补阳还五汤治疗VCI可减轻症状，调节Hcy、NSE及VEGF水平，促进认知功能和生活自理能力改善。
Abstract:
Objective:To investigate therapeutic effect of Tongdu Yinao acupuncture combined with Buyang Huanwu decoction on vascular cognitive impairment(VCI).Methods:A prospective randomized controlled study was employed.A total of 103 patients with VCI were randomly assigned into two groups by the envelope methods:51 cases in the control group and 52 cases in the acupuncture-medicine group.On the basis of symptomatic treatment,the control group were treated with Buyang Huanwu decoction,while the acupuncture-medicine group in addition to the treatment of the control group were further treated with Tongdu Yinao acupuncture.The levels of homocysteine (Hcy),neuron-specific enolase (NSE),vascular endothelial growth factor (VEGF),the mean blood flow velocity (Vm) of the anterior cerebral artery (ACA) and middle cerebral artery (MAC),the scores of montreal cognitive assessment scale (MoCA),Mini-Mental state examination(MMSE),activities of daily living scale(ADL),traditional Chinese medicine syndrome scores,clinical efficacy,and adverse reactions were compared between the two groups before and after treatment.Results:After treatment,the levels of Hcy and NSE in both groups were decreased compared with those before treatment,while the level of VEGF was increased,and magnitudes of change in the acupuncture-medicine group were greater than those in the control group (P＜0.05).After treatment,the Vm of ACA and MAC in both groups were improved compared with those before treatment,and the acupuncture-medicine group showed better improvement than those in the control group(all P＜0.05).After treatment,the scores of MoCA,MMSE,and ADL in both groups were elevated compared with those before treatment,and the acupuncture-medicine group had higher scores than the control group (all P＜0.05).After treatment,the scores of primary symptoms,secondary symptoms and the total scores in both groups were reduced compared with those before treatment,and the acupuncture-medicine group had lower scores than the control group(all P＜0.05).The total effective rate of clinical efficacy in the acupuncture-medicine group was higher than that in the control group (P＜0.05).There was no statistically significant difference in adverse reactions between the two groups (P＞0.05).Conclusion:Tongdu Yinao acupuncture combined with Buyang Huanwu decoction in the treatment of VCI can alleviate symptoms,regulate the levels of Hcy,NSE,and VEGF,promote improvement of cognitive function and activities of daily living.

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备注/Memo

备注/Memo:
湖南省中医药科研计划项目（D2022021）
更新日期/Last Update: 2025-07-09