[1]张淼,柳静,潘宇琛,等.散结滋阴法治疗儿童卵巢囊肿疗效观察[J].陕西中医,2025,46(9):1189-1192,1197.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.007]
　ZHANG Miao,LIU Jing,PAN Yuchen,et al.The clinical efficacy of the method of dispersing knots and nourishing yin in treating ovarian cysts in girls[J].,2025,46(9):1189-1192,1197.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.007]
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散结滋阴法治疗儿童卵巢囊肿疗效观察

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年9期
页码:
1189-1192,1197
栏目:
临床研究
出版日期:
2025-09-05

文章信息/Info

Title:
The clinical efficacy of the method of dispersing knots and nourishing yin in treating ovarian cysts in girls
作者:
张淼; 柳静; 潘宇琛; 冯锴
（国家儿童医学中心 首都医科大学附属北京儿童医院中医科，北京100045)
Author(s):
ZHANG Miao; LIU Jing; PAN Yuchen; FENG Kai
(Department of Traditional Chinese Medicine，National Center for Children’s Health，Beijing Children’s Hospital，Capital Medical University，Beijing 100045，China)
关键词:
卵巢囊肿; 青春期前儿童; 临床特点; 性早熟; 桂枝茯苓丸; 散结滋阴法
Keywords:
Ovarian cyst; Prepubertal girls; Clinical characteristics; Precocious puberty; Guizhi Fuling pill; Method of dispersing knots and nourishing Yin
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2025.09.007
文献标志码:
A
摘要:
目的：总结青春期前儿童卵巢囊肿（OC）临床特点，观察散结滋阴法治疗OC儿童临床疗效，对儿童第二性征、生长发育的影响。方法：选取OC（未达到手术指征）儿童95例作为研究对象，对照组（47例），观察组（48例），对照组脱落1例，观察组脱落2例，两组均有46例入组。对照组予桂枝茯苓丸(汤剂)治疗，观察组应用散结滋阴法治疗。比较两组治疗后的临床疗效，比较两组儿童治疗前后卵巢囊肿大小，子宫、卵巢容积、骨龄提前变化程度及性激素（E2）水平。结果：观察组总有效率显著高于对照组(P<0.05)；两组儿童治疗后E2水平均明显下降(P<0.01)，且观察组显著低于对照组(P<0.01)；两组儿童卵巢囊肿体积、子宫及卵巢容积较治疗前均明显缩小(P<0.05)，且观察组显著低于对照组(P<0.01)，观察组中29例治疗后卵巢囊肿完全消失。治疗后观察组骨龄提前明显减少(P<0.05)，显著优于对照组(P<0.05)。结论：散结滋阴法对OC儿童具有显著的干预作用，可有效减小卵巢囊肿体积，甚至消除卵巢囊肿，显著降低血清E2水平，减小子宫、卵巢容积，控制第二性征，延缓骨龄成熟速度，安全性高。
Abstract:
Objective:To summarise the clinical characteristics of prepubertal girls with ovarian cysts,and to observe the clinical efficacy of the method of dispersing knots and nourishing yin in treating ovarian cysts in girls,and its effect on the secondary sexual characteristics and growth and development of girls.Methods:95 cases of girls with ovarian cysts (not meeting surgical indications) were selected as the study subjects,control group (47 cases),observation group (48 cases),1 case of detachment in the control group,and 2 cases of detachment in the observation group,and 46 cases of girls in both groups were enrolled in the study.Guizhi Fuling pill (soup) was administered to the control group,while the observation group received treatment for knot dispersal and yin nourishment.A comparison was made between the two girl groups’ clinical effectiveness,focusing on ovarian cysts,uterus,ovary size,bone age progression,and sex hormone (E2) levels pre and post-treatment.Results:Findings revealed that the observation group’s overall effective rate,markedly surpassing the control group’s.Post-treatment,there was a significant reduction in the E2 levels of girls in both groups (P<0.01),with the observation group being markedly less than the control group (P<0.01).Additionally,the ovarian cysts,uterus,and ovary volume of girls in both groups notably diminished compared to the pre-treatment phase (P<0.05),moreover size of the observation group was much smaller in comparison to that of the control group(P<0.01).Notably,29 cases in the observation group had ovarian cysts completely disappeared after treatment.There was a notable decrease in bone age progression in the observation group (P<0.05),markedly surpassing the control group’s progress (P<0.05).Conclusion:The method of dispersing knots and nourishing yin has a significant intervention effect on ovarian cysts in girls,which can effectively reduce the volume of ovarian cysts or even eliminate them,significantly reduce E2 levels,reduce uterine and ovarian volume,control secondary sexual characteristics,and delay the rate of bone age maturation,with a high degree of safety.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82405475）；北京中医药薪火传承“新3+3”工程项目（2023-ZYSF-01)
更新日期/Last Update: 2025-09-08