[1]韩昕璘,翟文生,翟盼盼,等.中药调控JAK/STAT信号通路干预狼疮性肾炎机制研究进展[J].陕西中医,2025,46(9):1284-1288.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.027]
　HAN Xinlin,ZHAI Wensheng,ZHAI Panpan,et al.Research progress on the mechanism of traditional chinese medicine regulates JAK/STAT signaling pathway in treatment of lupus nephritis[J].,2025,46(9):1284-1288.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.027]
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中药调控JAK/STAT信号通路干预狼疮性肾炎机制研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年9期
页码:
1284-1288
栏目:
综 述
出版日期:
2025-09-05

文章信息/Info

Title:
Research progress on the mechanism of traditional chinese medicine regulates JAK/STAT signaling pathway in treatment of lupus nephritis
作者:
韩昕璘1; 2; 翟文生1; 2; 翟盼盼1; 2; 任相阁1; 2; 禹欣1; 2; 张智菲1; 2
（1.河南中医药大学第一附属医院儿科医院，河南 郑州 450000；2.河南中医药大学儿科医学院，河南 郑州 450000)
Author(s):
HAN Xinlin1; 2; ZHAI Wensheng1; 2; ZHAI Panpan1; 2; REN Xiangge1; 2; YU Xin1; 2; ZHANG Zhifei1; 2
(1.The Pediatric Hospital of the First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000，China;2.School of Pediatric Medicine of Henan University of Traditional Chinese Medicine,Zhengzhou 450000，China)
关键词:
系统性红斑狼疮; JAK/STAT信号通路; 狼疮性肾炎; 炎症反应; 免疫应答; 细胞凋亡
Keywords:
Systemic lupus erythematosus; JAK/STAT Signal pathway; Lupus nephritis; Inflammatory response; Immune response; Apoptosis
分类号:
R 593.241
DOI:
DOI:10.3969/j.issn.1000-7369.2025.09.027
文献标志码:
A
摘要:
狼疮性肾炎(LN)是继发性肾小球肾炎，是系统性红斑狼疮（SLE）累及肾脏的严重并发症，迄今发病机制尚未完全明确，可能与免疫功能异常、遗传因素及病毒感染有关。LN治疗周期长，药物毒不良反应明显，复发率高，目前亟待研究中医药对其治疗效果，以期提高LN患者生命质量。Janus激酶/信号转导子和转录激活子（JAK/STAT）信号通路在LN疾病进展中具有关键作用，磷酸化的STAT信号表达可能与LN发病机制密切相关。本文以JAK/STAT信号通路为切入点，总结其在炎症反应、免疫应答、细胞凋亡等方面对LN的调节作用，综合近年来中药单体及其化合物和中药制剂调控JAK/STAT信号通路治疗LN机制研究，认为中药调控JAK/STAT信号通路对LN防治具有重大意义，以期为LN的防治及药物研发提供参考。
Abstract:
Lupus nephritis (LN) is a secondary glomerulonephritis and a serious complication of systemic lupus erythematosus (SLE) affecting the kidneys.The pathogenesis of LN is not yet fully understood,and may be related to immune dysfunction,genetic factors,and viral infections.LN has a long treatment cycle,significant drug toxicity and side effects,and a high recurrence rate.Currently,there is an urgent need to study the therapeutic effect of traditional Chinese medicine on LN patients in order to improve their quality of life.The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway plays a crucial role in the progression of LN disease,and phosphorylated STAT signal expression may be closely related to the pathogenesis of LN.This paper takes the JAK/STAT signaling pathway as the entry point,summarizes its regulatory effects on LN in inflammatory responses,immune responses,apoptosis,and other aspects,and synthesizes recent research on the mechanisms of traditional Chinese medicine monomers,their compounds,and traditional Chinese medicine preparations in regulating the JAK/STAT signaling pathway for LN treatment.It is concluded that the regulation of the JAK/STAT signaling pathway by traditional Chinese medicine holds significant importance for the prevention and treatment of LN,with the aim of providing references for LN prevention,treatment,and drug development.

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备注/Memo

备注/Memo:
国家自然科学基金资助面上项目(82274577)
更新日期/Last Update: 2025-09-08