[1]周欣,王永莉,汪妍.滋癸益经汤联合激素治疗对脾肾阳虚型卵巢早衰患者相关激素水平及预后的影响[J].陕西中医,2025,46(12):1628-1631,1641.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.008]
　ZHOU Xin,WANG Yongli,WANG Yan.Effect of Zigui Yijing decoction combined with hormone therapy on hormone levels and prognosis in premature ovarian failure of spleen-kidney yang deficiency type[J].,2025,46(12):1628-1631,1641.[doi:DOI:10.3969/j.issn.1000-7369.2025.12.008]
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滋癸益经汤联合激素治疗对脾肾阳虚型卵巢早衰患者相关激素水平及预后的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年12期
页码:
1628-1631,1641
栏目:
临床研究
出版日期:
2025-12-05

文章信息/Info

Title:
Effect of Zigui Yijing decoction combined with hormone therapy on hormone levels and prognosis in premature ovarian failure of spleen-kidney yang deficiency type
作者:
周欣; 王永莉; 汪妍
（无锡市中医医院治未病科，江苏 无锡 214071）
Author(s):
ZHOU Xin; WANG Yongli; WANG Yan
（Department of Preventive Medicine,Wuxi Traditional Chinese Medicine Hospital,Wuxi 214071,China）
关键词:
卵巢早衰; 滋癸益经汤; 脾肾阳虚; 激素; 月经; 戊酸雌二醇
Keywords:
Premature ovarian failure; Zigui Yijing decoction; Spleen-kidney yang deficiency; Hormone; Menstruation; Estradiol valerate
分类号:
R 711.75
DOI:
DOI:10.3969/j.issn.1000-7369.2025.12.008
文献标志码:
A
摘要:
目的：研究滋癸益经汤联合激素对脾肾阳虚型卵巢早衰患者相关激素水平以及预后的影响。方法：选取脾肾阳虚型卵巢早衰患者80例，分为对照组和研究组，各40例，对照组患者接受激素治疗，研究组患者接受激素联合滋癸益经汤治疗，共治疗3个月。比较两组患者治疗前后中医症候积分、卵巢功能以及血清激素（卵泡生成素、睾酮、黄体生成素）水平，并比较两组患者临床治疗疗效、治疗后月经复潮率以及治疗期间不良反应。结果：研究组患者治疗后总有效率高于对照组患者（95.00% 与75.00%，P<0.05）。治疗后，对照组患者中医症候积分和血清激素水平均降低（P<0.05），但均显著高于研究组患者（P<0.05）。两组患者治疗后卵巢体积、卵泡数量和卵巢血流收缩期峰值流速均升高，且研究组患者治疗后各项卵巢功能均高于对照组患者（P<0.05）。研究组患者治疗后半年内月经复潮>2次患者比例显著高于对照组患者（45.00% 与 15.00%，P<0.05），但两组患者治疗期间不良反应总发生率比较无统计学差异（40.00% 与32.50%，P>0.05）。结论：滋癸益经汤对脾肾阳虚型卵巢早衰具有显著的临床疗效，可显著改善患者性激素水平，提高患者卵巢功能和月经复潮率，安全有效。
Abstract:
Objective:The study investigates the effects of Zigui Yijing decoction combined with hormones on hormone levels and prognosis in premature ovarian failure of the spleen-kidney yang deficiency type.Methods:A total of 80 patients with ovarian failure of spleen and kidney yang deficiency were selected and divided into control group and study group,each with 40 cases,and the patients in the control group received hormone therapy,and the study group received hormone combined with Zigui Yijing decoction for a total of 3 months.Before and after treatment,we compared the TCM syndrome score,ovarian function,serum levels of follicle stimulating hormone,testosterone and luteinizing hormone,the efficacy of treatment,menstrual resurgence rate after treatment and adverse reactions.Results:For the total effective rate,the study group was higher than control group (95.00% vs 75.00%,P<0.05).After treatment,the TCM syndrome scores and serum FSH,LH and T hormone levels of the control groups were decreased (P<0.05),and all strongly higher than the study group (P<0.05).The ovarian volume,the number of follicles and peak systolic flow velocity of ovarian blood flow were increased in the two groups (P<0.05),and the ovarian functions was higher in the study group (P<0.05).After treatment,the proportion of patients in the study group who had two menstrual cramps > two times within six months (45.00% vs 15.00%,P<0.05),but there was no significant difference in the overall incidence of adverse reactions between the two groups during treatment (40.00% vs 32.50%,P>0.05).Conclusion:Zigui Yijing decoction has a significant clinical effect on premature ovarian failure with spleen-kidney yang deficiency,which can significantly improve the level of sex hormones in patients,improve ovarian function and menstrual resurgence rate in patients,and is safe and effective.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82305147）
更新日期/Last Update: 2025-12-08