[1]涂泽宇,李映虹,褚天璐,等.中药通过脂质代谢重编程治疗胃癌的研究进展[J].陕西中医,2026,(1):120-125.[doi:DOI:10.3969/j.issn.1000-7369.2026.01.022]
　TU Zeyu,LI Yinghong,CHU Tianlu,et al.Research progress of traditional Chinese medicine in the treatment of gastric cancer through lipid metabolism reprogramming[J].,2026,(1):120-125.[doi:DOI:10.3969/j.issn.1000-7369.2026.01.022]
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中药通过脂质代谢重编程治疗胃癌的研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年1期
页码:
120-125
栏目:
综 述
出版日期:
2026-01-05

文章信息/Info

Title:
Research progress of traditional Chinese medicine in the treatment of gastric cancer through lipid metabolism reprogramming
作者:
涂泽宇1; 2; 李映虹1; 2; 褚天璐1; 2; 官恒超1; 2; 束昕妍1; 2; 滕钰浩1; 3; 徐媛媛1; 3; 舒鹏1; 2; 3
（1.南京中医药大学附属医院，江苏 南京 210029；2.南京中医药大学，江苏 南京 210029；3.江苏省中医院,江苏 南京 210029）
Author(s):
TU Zeyu1; 2; LI Yinghong1; 2; CHU Tianlu1; 2; GUAN Hengchao1; 2; SHU Xinyan1; 2; TENG Yuhao1; 3; XU Yuanyuan1; 3; SHU Peng1; 2; 3
(1.Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing 210029，China;2.Nanjing University of Traditional Chinese Medicine,Nanjing 210029，China;3.Traditional Chinese Medicine Hospital of Jiangsu Province,Nanjing 210029，China)
关键词:
胃癌; 脂质代谢; 中药; 中药复方; 作用机制
Keywords:
Gastric cancer; Lipid metabolism; Traditional Chinese medicine; Chinese medicine compounds; Mechanism of action
分类号:
R 735.2
DOI:
DOI:10.3969/j.issn.1000-7369.2026.01.022
文献标志码:
A
摘要:
胃癌（GC）是发生于胃黏膜上皮和腺上皮的恶性肿瘤，其早期诊断率低，死亡率高，临床治疗时首选手术切除，并配合放化疗、靶向治疗等综合治疗。脂质代谢重编程是恶性肿瘤的显著特征之一，通过调控脂质代谢相关蛋白、酶、基因及通路的改变，在GC的增殖、迁移、侵袭和耐药等过程中发挥着重要作用。中药在GC治疗过程中应用广泛，研究发现，中药有效成分和中药复方可以通过调节脂质代谢重编程诱导GC细胞发生凋亡或铁死亡，进而抑制其增殖、迁移、侵袭及耐药性。通过系统归纳中药有效成分和中药复方调控GC脂质代谢重编程的机制和临床效果，可为后续开展实验研究和药物研发奠定理论基础。
Abstract:
Gastric cancer (GC) is a malignant tumor that occurs in the gastric mucosal epithelium and glandular epithelium,with low early diagnosis rates and high mortality.The first choice in clinical treatment is surgical resection,combined with radiochemotherapy,targeted therapy,and other comprehensive treatments.Lipid metabolic reprogramming is one of the significant characteristics of malignant tumors.By regulating changes in lipid metabolism-related proteins,enzymes,genes,and pathways,it plays a crucial role in the proliferation,migration,invasion,and drug resistance of GC.Traditional Chinese medicine is widely used in the treatment of GC.Research has found that the active components of traditional Chinese medicine and traditional Chinese medicine compound preparations can induce apoptosis or ferroptosis in GC cells by regulating lipid metabolic reprogramming,thereby inhibiting their proliferation,migration,invasion,and drug resistance.By systematically summarizing the mechanisms and clinical effects of traditional Chinese medicine active components and traditional Chinese medicine compound preparations in regulating lipid metabolic reprogramming in GC can lay a theoretical foundation for subsequent experimental research and drug development.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82374539）；江苏省中医药科技发展计划重点项目（ZD202214）；江苏省中医药领军人才培养对象项目（SLJ0327）；南京中医药大学胃癌临床专病研究院项目（LCZBYJYZZ2024-001）
更新日期/Last Update: 2026-01-08