[1]邹晨冉,吴蓓,苏梦焱,等.基于浊瘀互结理论与中性粒细胞胞外诱捕网关联性探讨痛风性关节炎病机[J].陕西中医,2026,(2):213-217.[doi:DOI:10.3969/j.issn.1000-7369.2026.02.012]
　ZOU Chenran,WU Bei,SU Mengyan,et al.Pathogenesis of gouty arthritis explored based on correlation between turbidity and blood stasis and extracellular trap of neutrophils[J].,2026,(2):213-217.[doi:DOI:10.3969/j.issn.1000-7369.2026.02.012]
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基于浊瘀互结理论与中性粒细胞胞外诱捕网关联性探讨痛风性关节炎病机

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年2期
页码:
213-217
栏目:
学术探讨
出版日期:
2026-02-05

文章信息/Info

Title:
Pathogenesis of gouty arthritis explored based on correlation between turbidity and blood stasis and extracellular trap of neutrophils
作者:
邹晨冉1; 吴蓓1; 苏梦焱1; 刘康楠1; 郑书佳1; 杜冰洁1; 周子朋2
（1.河南中医药大学，河南 郑州 450000；2.河南省中医院，河南 郑州 450003）
Author(s):
ZOU Chenran1; WU Bei1; SU Mengyan1; LIU Kangnan1; ZHENG Shujia1; DU Bingjie1; ZHOU Zipeng2
（1.Henan University of Traditional Chinese Medicine,Zhengzhou 450000，China；2.Henan Provincial Hospital of Traditional Chinese Medicine，Zhengzhou 450003，China）
关键词:
痛风性关节炎; 浊瘀互结; 中性粒细胞胞外诱捕网; 尿酸盐; 恶性循环
Keywords:
Gouty arthritis; Turbidity and blood stasis intermingled; Neutrophil extracellular traps; Urate; Vicious circle
分类号:
R 971
DOI:
DOI:10.3969/j.issn.1000-7369.2026.02.012
文献标志码:
A
摘要:
痛风性关节炎（GA）是一种由嘌呤代谢失调、单钠尿酸盐(MSU)晶体沉积引发的炎症性关节疾病，属中医学“白虎历节”范畴，其核心病机为“浊瘀互结”。近年来研究发现，中性粒细胞胞外诱捕网（NETs）在痛风性关节炎的发病机制中起着关键作用。基于中医“浊瘀”理论，结合现代免疫学中NETs的研究，系统探讨二者在痛风性关节炎发生发展中的内在联系。MSU晶体作为“浊邪”的微观体现，通过激活Toll样受体及NLRP3炎症小体通路，诱导中性粒细胞发生NETosis，形成以DNA为骨架并镶嵌多种颗粒蛋白的NETs，这一过程体现了“因浊致瘀”的病理演变。NETs凭借其独特的生物学特性，在疾病过程中呈现双重作用。急性期，通过其黏滞特性捕获MSU晶体，释放组蛋白、髓过氧化物酶等毒性成分，加剧局部炎症反应和微循环障碍，表现为典型的红、肿、热、痛症状。慢性期，通过促进纤维化和持续炎症，参与痛风石的形成过程。NETs导致的微循环障碍可引起组织缺氧和组织液pH值下降，进而促使尿酸盐析出，形成“因瘀增浊”的恶性循环。这一发现从现代免疫学角度深化了对“浊瘀互结”理论科学内涵的认识，不仅为理解痛风性关节炎“反复发作，缠绵难愈”的临床特点提供了新的理论依据，也为中西医结合防治该病提供了潜在的作用靶点和研究方向。
Abstract:
Gouty arthritis (GA) is an inflammatory joint disease caused by purine metabolism disorder and monosodium urate (MSU) crystal deposition,which falls within the category of White Tiger Arthralgia in traditional Chinese medicine.Its core pathogenesis is congestion and stasis interlocking.Recent studies have found that neutrophil extracellular traps (NETs) play a key role in the pathogenesis of gouty arthritis.Based on the congestion and stasis theory in traditional Chinese medicine and the research on NETs in modern immunology,this paper systematically explores the intrinsic connection between the two in the occurrence and development of gouty arthritis.MSU crystals,as the microscopic manifestation of congestion,activate Toll-like receptors and NLRP3 inflammasome pathways,inducing neutrophils to undergo NETosis and form NETs with DNA as the framework and various granular proteins embedded.This process reflects the pathological evolution of congestion leading to stasis.NETs,with their unique biological characteristics,exhibit a dual role in the disease process.In the acute phase,they capture MSU crystals through their adhesive properties,release toxic components such as histones and myeloperoxidase,intensify local inflammatory responses and microcirculation disorders,and present typical symptoms of redness,swelling,heat,and pain.In the chronic phase,they promote fibrosis and persistent inflammation,participating in the formation of tophi.The microcirculation disorders caused by NETs can lead to tissue hypoxia and a decrease in tissue fluid pH,further promoting the precipitation of urate salts,forming a stasis increasing congestion vicious cycle.This discovery deepens the understanding of the scientific connotation of the congestion and stasis interlocking theory from the perspective of modern immunology,not only providing a new theoretical basis for understanding the clinical characteristics of gouty arthritis such as repeated attacks and difficult to cure,but also offering potential targets and research directions for the integrated prevention and treatment of this disease in traditional Chinese and Western medicine.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（81874456）；国家中医临床研究基地专项课题（2021JDZX2123）；国家老中医第七批师承学术继承人（国中医人教函〔2022〕76号）；河南省中医药科学研究专项课题（2024ZY1011）
更新日期/Last Update: 2026-02-09