[1]王凤池,HONG Munsoon(韩国),王玲玲,等.育肾培元内外同治法治疗卵巢储备功能减退临床研究[J].陕西中医,2026,(3):317-322.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.005]
　WANG Fengchi,HONG Munsoon,WANG Lingling,et al.Clinical study on kidney-tonifying and internal-external treatment for diminished ovarian reserve[J].,2026,(3):317-322.[doi:DOI:10.3969/j.issn.1000-7369.2026.03.005]
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育肾培元内外同治法治疗卵巢储备功能减退临床研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年3期
页码:
317-322
栏目:
临床研究
出版日期:
2026-03-05

文章信息/Info

Title:
Clinical study on kidney-tonifying and internal-external treatment for diminished ovarian reserve
作者:
王凤池1; HONG Munsoon1(韩国); 王玲玲2; 谭丽1; 张婷婷1
（1.上海中医药大学附属岳阳中西医结合医院，上海 200437；2.上海市北蔡社区卫生服务中心，上海 201204）
Author(s):
WANG Fengchi1; HONG Munsoon1; WANG Lingling2; TAN Li1; ZHANG Tingting1
(1.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;2.Community Health Service Center in Beicai Town,Pudong New District,Shanghai 201204,China)
关键词:
卵巢储备功能减退; 育肾培元; 内外同治; 加味养精种玉汤; 穴位敷贴; 炎症因子
Keywords:
Diminished ovarian reserve; Kidney-tonifying; Internal-external treatment; Jiawei Yangjing Zhongyu decoction; Acupoint application;  Inflammatory factor
分类号:
R 271.9
DOI:
DOI:10.3969/j.issn.1000-7369.2026.03.005
文献标志码:
A
摘要:
摘要 目的：观察加味养精种玉汤联合穴位敷贴治疗卵巢储备功能减退（DOR）患者的临床疗效，探讨育肾培元、内外同治法对性激素水平、卵泡发育及炎症因子的影响。方法：将64例DOR患者1∶1随机分为试验组、对照组，两组均予加味养精种玉汤治疗，试验组联合助阳方穴位敷贴综合治疗。治疗3个月后，比较两组性激素水平、炎症因子指标、超声评价指标、月经情况评分、中医证候评分和总有效率。结果：治疗后，试验组促卵泡刺激素（FSH）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-21（IL-21）、白细胞介素-1β（IL-1β）、转化生长因子-β1（TGF-β1）水平、中医证候评分均较对照组降低（P＜0.05或P＜0.01），抗缪勒管激素（AMH）、总有效率均较对照组升高（P＜0.05）。试验组窦卵泡计数（AFC）治疗后较治疗前升高（P＜0.01），雌二醇（E2）治疗后较治疗前有升高（P＜0.05），试验组与对照组月经情况评分治疗后均较治疗前降低（P＜0.01）。结论：育肾培元内外同治法可以降低DOR患者的FSH水平，改善AMH、E2水平及炎症状态，改善卵泡数，疗效优于单纯内服加味养精种玉汤治疗。
Abstract:
Objective:This study assessed the clinical response to Jiawei Yangjing Zhongyu decoction combined with acupoint application in patients with diminished ovarian reserve (DOR),and explored the effects of kidney-tonifying and internal-external treatment on sex hormone levels,follicular development,and inflammatory factors.Methods:Sixty-four DOR patients who met the inclusion criteria were randomized in a 1∶1 manner into the experimental and control groups.Both groups received Jiawei Yangjing Zhongyu decoction,while the experimental group received additional treatment with acupoint application of a Yang-tonifying formula.After three months of treatment,sex hormone levels,inflammatory factor markers,ultrasound evaluation indicators,menstrual status scores,TCM syndrome scores,and total effective rate were compared between the two groups.Results:After treatment,the experimental group showed significantly lower levels of FSH,TNF-α,IL-6,IL-21,IL-1β,TGF-β1,TGF-β1 TCM syndrome score compared to the control group (P<0.05 or P<0.01),while AMH and the total effective rate were significantly higher (P<0.05).Compared with pre-treatment levels,AFC in the experimental group increased after treatment (P<0.01),and E2 also increased after treatment (P<0.05).Both groups exhibited reductions in menstrual status scores after the intervention (P<0.01).Conclusion:The combined internal and external treatment method of nourishing the kidneys and strengthening the body can reduce FSH levels,improve AMH and E2 levels and inflammatory status,and improve follicle counts in patients with DOR.Its efficacy is superior to that of simply taking the modified Yangjing Zhongyu decoction internally.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82374499）；国家中医药管理局高水平中医药重点学科建设项目（ZYYZDXK-2023065）；中医医院临床数据标准应用示范研究项目（GHC-2024-WTBS-005）
更新日期/Last Update: 2026-03-05