[1]李嘉欣,曲妮妮,项继静.基于“卫气理论”探讨支气管哮喘的免疫发病机制[J].陕西中医,2026,(4):512-516.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.015]
　LI Jiaxin,QU Nini,XIANG Jijing.Exploring the immunopathogenesis of bronchial asthma based on “Wei Qi theory”[J].,2026,(4):512-516.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.015]
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基于“卫气理论”探讨支气管哮喘的免疫发病机制

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年4期
页码:
512-516
栏目:
学术探讨
出版日期:
2026-04-05

文章信息/Info

Title:
Exploring the immunopathogenesis of bronchial asthma based on “Wei Qi theory”
作者:
李嘉欣1; 曲妮妮2; 项继静3
（1.辽宁中医药大学，辽宁 沈阳 110847；2.辽宁中医药大学附属医院，辽宁 沈阳 110000；3.沈阳市苏家屯区中心医院，辽宁 沈阳 110101）
Author(s):
LI Jiaxin1; QU Nini2; XIANG Jijing3
（1.Liaoning University of Traditional Chinese Medicine,Shenyang 110847，China;2.Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000，China;3.Shenyang Sujiatun District Central Hospital,Shenyang 110101，China）
关键词:
支气管哮喘; 卫气理论; 黏膜免疫; 时间节律; 细胞免疫
Keywords:
Bronchial asthma; Wei Qi theory; Mucosal immunity; Temporal rhythm; Cellular immunity
分类号:
R 256.12
DOI:
DOI:10.3969/j.issn.1000-7369.2026.04.015
文献标志码:
A
摘要:
支气管哮喘作为呼吸系统的常见疾病，其发病多被认为与现代免疫学机制密切相关，而中医“卫气”因与免疫系统在结构和功能上的相似性，为支气管哮喘的免疫发病机制提供独特的阐释框架。卫气循行于“皮毛”，其“屏障”“防御”和“监督”功能与气道上皮的黏膜免疫及细胞免疫等功能高度对应。卫气的昼夜规律与支气管哮喘凌晨及夜间好发的免疫节律相似。卫气卫外不固或运行失常均可导致哮喘发病。故提出在“卫气理论”指导下治疗哮喘，通过调气和卫，调节免疫平衡，增强免疫防御和自稳功能，以期提高哮喘的临床疗效，也是发挥中医“治未病”优势的所在。故本文旨在系统梳理卫气理论与哮喘免疫发病机制的内在联系，为中西医结合防治哮喘提供理论依据。
Abstract:
Bronchial asthma,as a common disease of the respiratory system,is mostly considered to be closed related to modern immunological mechanisms.In traditional Chinese medicine (TCM),the concept of “Wei Qi” offers a unique explanatory framework for understanding the immunopathogenesis of bronchial asthma,owing to its structural and functional resemblance to the immune system.Wei Qi circulates through the “skin and hair”,and its functions of “barrier”,“defense”,and “supervision” closely align with the mucosal and cellular immune functions of the airway epithelium.The diurnal rhythm of Wei Qi mirrors the immune rhythm observed in bronchial asthma,which tends to manifest more frequently in the early morning and at night.Deficiency or dysfunction of Wei Qi in its exterior-protecting and circulatory functions can result in the onset of asthma.It is proposed to treat asthma under the guidance of the “Wei Qi theory” by regulating Wei Qi,restoring immune balance,and enhancing immune defense and self-stabilizing functions,thereby improving the clinical efficacy of asthma treatment.This approach also capitalizes on the strength of TCM in “preventing disease”.Therefore,this article aims to systematically elucidate the intrinsic link between the Wei Qi theory and the immunopathogenesis of asthma,thereby providing a theoretical foundation for the integrated prevention and treatment of asthma using traditional Chinese and Western medicine.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82374378）；辽宁省自然科学基金资助项目（2024-MSLH-260）；辽宁省博士科研启动基金计划项目（2024-BS-145）
更新日期/Last Update: 2026-04-05