[1]孟彦利,梁绿圆,张霞.基于巨噬细胞极化从“虚气留滞”探讨儿童狼疮性肾炎的发病及辨治[J].陕西中医,2026,(6):787-791.[doi:DOI:10.3969/j.issn.1000-7369.2026.06.012]
　Discussion on the pathogenesis and treatment of childhood lupus nephritis based on macrophage polarization from deficient qi and stagnation.Discussion on the pathogenesis and treatment of childhood lupus nephritis based on macrophage polarization from “deficient qi and stagnation”[J].,2026,(6):787-791.[doi:DOI:10.3969/j.issn.1000-7369.2026.06.012]
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基于巨噬细胞极化从“虚气留滞”探讨儿童狼疮性肾炎的发病及辨治

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年6期
页码:
787-791
栏目:
学术探讨
出版日期:
2026-06-05

文章信息/Info

Title:
Discussion on the pathogenesis and treatment of childhood lupus nephritis based on macrophage polarization from “deficient qi and stagnation”
作者:
孟彦利1; 2; 梁绿圆1; 2; 张霞1; 2
（1.河南中医药大学第一附属医院儿科医院,河南 郑州 450099；2.河南中医药大学儿科医学院,河南 郑州 450046）
Author(s):
Discussion on the pathogenesis and treatment of childhood lupus nephritis based on macrophage polarization from “deficient qi and stagnation”
(1.Pediatric Hospital,First Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450099，China;2.School of Pediatrics,Henan University of Traditional Chinese Medicine，Zhengzhou 450046，China)
关键词:
虚气留滞; 巨噬细胞极化; 狼疮性肾炎; 儿科; 中医
Keywords:
Deficient qi and stagnation; Macrophage polarization; Lupus nephritis; Pediatrics; Traditional Chinese medicine
分类号:
R 593.242
DOI:
DOI:10.3969/j.issn.1000-7369.2026.06.012
文献标志码:
A
摘要:
狼疮性肾炎是儿童常见的继发性免疫性肾小球疾病，目前发病机制尚未明确，中医认为总属本虚标实，与“虚气留滞”理论相通。巨噬细胞作为人体重要的免疫细胞，通过在不同微环境信号诱导下极化为不同表型，发挥免疫调节、维持稳态、组织修复等作用，与“虚气留滞”的临床征象相仿。基于此，结合狼疮性肾炎的发病特点及儿童的发育特点，本文认为巨噬细胞功能活动减退所致的“虚气”是狼疮性肾炎发病的基础，其极化失衡所致的“郁、瘀、毒、湿”等病理产物的“留滞”是推动狼疮性肾炎发生发展的重要环节。结合临床辨证施治，临证应“补虚”与“行滞”并举，急性活动期重除“滞”，轻补“虚”；修复缓解期重补“虚”，清余“滞”；慢性稳定期补本“虚”，防复“滞”。基于巨噬细胞极化从“虚气留滞”探讨儿童狼疮性肾炎的发病及辨治，有助于拓宽诊疗思路，指导临床实践，为后续精准干预提供创新方向，改善患儿长期预后。
Abstract:
Lupus nephritis,a prevalent secondary immune-related glomerular disorder in children,remains pathogenesis-unresolved in western medicine.Traditional Chinese Medicine (TCM)identifies it as a syndrome characterized by “root deficiency with surface excess”,aligning with the clinical concept of “deficient qi and stagnation”.Macrophages,vital immune cells that polarize into diverse phenotypes under microenvironmental signals,perform functions including immune regulation,homeostasis maintenance,and tissue repair—phenomena mirroring“deficient qi and stagnation”.This study proposes that diminished macrophage activity-induced “deficient qi” serves as the pathological foundation of lupus nephritis.The imbalance in macrophage polarization leads to the stagnation of pathological products such as “stagnation,stasis,toxicity,and dampness”,which critically drive disease progression.Clinical management should balance“tonifying deficiency” with “dispelling stagnation”:prioritizing “stasis removal” during acute flare-ups while emphasizing “deficiency tonification”;focusing on “deficiency replenishment” with residual“stasis clearance” in remission phases;and implementing “deficiency-based tonification” with “stasis prevention” in chronic stable states.Based on macrophage polarization,exploring the pathogenesis and treatment of lupus nephritis in children from “deficient qi and stagnation” is helpful to expand diagnostic pathways,guide clinical practice,and improve long-term prognosis for affected children.

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备注/Memo

备注/Memo:
国家自然基金资助项目（82474568）；中华中医药学会团体标准科研项目（20230904-BZ-CACM）；河南省中医学“双一流”创建科学研究专项（HSRP-DFCTCM-2023-2-10）
更新日期/Last Update: 2026-06-11