[1]王玉梅,袁向东,李四保.止咳平喘糖浆联合异丙托溴铵治疗哮喘疗效及对患儿肺功能和内环境的影响*[J].陕西中医杂志,2019,(4):428-430.
　WANG Yumei,YUAN Xiangdong,LI Sibao..Curative effect of cough relieving asthma syrup combined with ipratropium bromide on children with asthma and its influence on pulmonary function and internal environment[J].,2019,(4):428-430.
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止咳平喘糖浆联合异丙托溴铵治疗哮喘疗效及对患儿肺功能和内环境的影响*
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年4期
页码:
428-430
栏目:
临床研究
出版日期:
2019-04-05

文章信息/Info

Title:
Curative effect of cough relieving asthma syrup combined with ipratropium bromide  on children with asthma and its influence on pulmonary function and internal environment
文章编号:
DOI:10.3969/j.issn.10007369.2019.04.006
作者:
王玉梅1; 袁向东1; 李四保
1.河南省商丘市第一人民医院（商丘 476100）；2.郑州大学第三附属医院儿内科（郑州450000）
Author(s):
WANG Yumei; YUAN Xiangdong; LI Sibao.
Shangqiu First People’s Hospital in Henan Province(Shangqiu 476100)
关键词:
止咳平喘糖浆; 异丙托溴铵; 哮喘; 儿童; 肺功能; 内环境; 联合治疗
Keywords:
Key words Cough relieving asthma syrup; Ipratropium bromide; Asthmatic; Children; pulmonary function; Internal environment; Combined therapy
分类号:
R562.25
文献标志码:
A
摘要:
摘 要 目的：探讨止咳平喘糖浆联合异丙托溴铵治疗哮喘患儿的疗效及对患儿肺功能和内环境的影响。方法：将哮喘患儿82例采用随机数字表法随机分为治疗组和对照组，给予对照组患儿异丙托溴铵治疗，治疗组患儿在对照组用药治疗基础上加以止咳平喘糖浆治疗，观察两组患儿治疗后的临床疗效、复发率以及肺功能和血清炎性细胞因子水平指标。结果：治疗组患儿治疗后的总有效率为92.7%，明显优于对照组的70.7%，差异比较具有统计学意义（P＜0.05）；治疗组患儿治疗后的肺功能指标FEV1、FEV1/FVC值为（93.6±16.6）L/s、（96.5±14.7）与对照组（76.5±8.3）L/s、（85.3±14.3）相比，差异比较具有统计学意义（P＜0.05）；治疗组患儿治疗后的血清炎性细胞因子水平指标：IL6、TNFα、VEGF等为（103.4±25.3）ng/L、（50.3±13.7）ng/L、（113.6±16.6）ng/L与对照组（121.4±25.5）ng/L、（71.3±13.5）ng/L、（165.4±25.2）ng/L相比，差异比较具有统计学意义（P＜0.05）；治疗患儿治疗后复发率为7.3%，明显低于对照组的26.8%，差异比较有统计学意义（P＜0.05）。结论： 止咳平喘糖浆联合异丙托溴铵治疗哮喘患儿的疗效显著、降低复发率，且能明显改善患儿肺功能，并调节内环境水平。
Abstract:
Abstract Objective：To investigate the rapeutic effect of cough relieving asthma syrup combined with ipratropium bromide on asthmatic children and its influence on pulmonary function and internal environment. Methods ：82 children with asthma were randomly divided into observation group and control group by random number table. The control group was treated with ipratropium bromide. The treatment group was treated with cough relieving asthma syrup on the basis of the treatment of the control group. The clinical efficacy，recurrence rate，pulmonary function and serum inflammatory cytokine levels of the two groups were observed. Results：After treatment，the total effective rate of the treatment group was 92.7%，significantly better than 70.7% of the control group，with significant difference (P＜0.05)；after treatment，the FEV1 and FEV1/FVC of the treatment group were (93.6±16.6) L/s，(96.5±14.7) and the control group were (76.5±8.3) L/s，(85.3±14.3)，with significant difference (P＜0.05). The levels of serum inflammatory cytokines in children after treatment were (103.4±25.3) ng/L，(50.3±13.7) ng/L，(113.6±16.6) ng/L and control group (121.4±25.5) ng/L，(71.3±13.5) ng/L，(165.4±25.2) ng/L. The recurrence rate of children after treatment was 7.3%，which was significantly lower than that of control group26.8%(P＜0.05). the difference was significant (P＜0.05).Conclusion：Cough relieving asthma syrup combined with ipratropium bromide in the treatment of children with asthma has significant curative effect，reduces the recurrence rate，and can significantly improve the pulmonary function of children with asthma，and regulate the level of internal environment. 

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备注/Memo

备注/Memo:
*河南省科技攻关项目（182102310160）
更新日期/Last Update: 2019-04-24