[1]邵翠丽,周晋华△,杨勤军,等.周晋华运用环磷酰胺联合中药紫杉治疗晚期肺癌经验*[J].陕西中医杂志,2020,(2):223-225.
　SHAO Cuili,ZHOU Jinhua,YANG Qinjun,et al.ZHOU Jinhua treats advanced lung cancer with cyclophosphamide and purple shirt[J].,2020,(2):223-225.
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周晋华运用环磷酰胺联合中药紫杉治疗晚期肺癌经验*
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2020年2期
页码:
223-225
栏目:
名老中医经验
出版日期:
2020-02-05

文章信息/Info

Title:
ZHOU Jinhua treats advanced lung cancer with cyclophosphamide and purple shirt
文章编号:
DOI:〖HT5K〗10.3969/j.issn.10007369.2020.02.023
作者:
邵翠丽1; 周晋华2△; 杨勤军1; 陈思思1
1.安徽中医药大学(合肥 230038); 2.安徽中医药大学第一附属医院(合肥 230038)
Author(s):
SHAO Cuili; ZHOU Jinhua; YANG Qinjun; et al.
Anhui University of Traditional Chinese Medicine(Hefei 230038)
关键词:
肺癌;  晚期;  低剂量化疗;  环磷酰胺;  紫杉;  姑息性治疗
Keywords:
Lung cancer;  Late stage;  Low dose chemotherapy;  Cyclophosphamide;  Purple shirt;  Palliative treatment
分类号:
R734.2
文献标志码:
A
摘要:
肺癌多是邪祟之物郁结留滞致使人体气血运行不畅所致,周晋华主任认为肺癌的发生与正虚邪害密不可分,而晚期肿瘤患者虚多实少,全身为虚,当以脾虚为主,“得脾胃者得中央,得中央者得天下”,局部为实,故当以缓治,固脾胃之本培人体之元,周晋华主任运用低剂量规律口服环磷酰胺联合中药紫杉片解毒散结配伍,佐以益气健脾之法治疗晚期肺癌患者,发现对身体基础状况较差的老年肿瘤患者有良好的效果,此法是从姑息性治疗角度运用中西医结合的方法将静脉化疗药环磷酰胺改为口服,在提高老年患者对化疗药物的耐受性,减轻化疗副作用方面有一定的优势,为临床治疗晚期肺癌提供一种新思维。
Abstract:
Lung cancer is mostly caused by stagnation of evil things,resulting in poor circulation of Qi and blood.According to director ZHOU Jinhua,the occurrence of lung cancer is closely related to the damage of positive deficiency and evil.However,in the late stage of tumor patients,the deficiency is more and less,and the whole body is deficiency.When spleen deficiency is the main factor,“the one who has the spleen and stomach gets the center,the one who has the center gets the world”,and the part is the solid factor.Therefore,it is necessary to cultivate the human body based on the principle of slow treatment and strengthening the spleen and stomach,Director ZHOU Jinhua used low-dose regular oral cyclophosphamide combined with Chinese medicine yew tablet detoxification powder,combined with the method of benefiting qi and invigorating the spleen to treat the hopeless patients with advanced lung cancer.He found that it had good effect on the elderly patients with poor basic condition of body.This method is to change the intravenous chemotherapy drug cyclophosphamide into oral one from the perspective of palliative treatment by using the method of combination of Chinese and western medicine to improve the tolerance of elderly patients to chemotherapy drugs and reduce the side effects of chemotherapy has certain advantages,which provides a new thinking for the clinical treatment of advanced lung cancer.

参考文献/References:

[1] Gkiozos I,Charpidou A,Syrigos K.Developments in the treatment of Non-small cell lung cancer[J].Anticancer Research,2007,27(4C):2823-2827.
[2] Torre LA,Bray F,Siegel RL,et al.Global cancer statistics,2012[J].Ca A Cancer Journal for Clinicians,2015,65(2):87-108.
[3] Zheng RS,Zeng HM,Zhang SW,et al.Estimates of cancer incidence and mortality in China,2013[J].Chinese Journal of Cancer,2017,36(8):384-389.
[4] 曹启生,韩溢洪,秦 毅,等.分层治疗晚期非小细胞肺癌160例[J].长江大学学报:自然版,2018,15(4):61-63.
[5] 张 静,刘素勤,张 洁,等.晚期非小细胞肺癌二线治疗不同方案的疗效及成本效益分析[J].临床肿瘤学杂志,2012,17(10):908-911.
[6] 康欣梅,张清媛,佟丹丹,等.低剂量化疗抑制肺癌血管生成的研究[J].中国肺癌杂志,2005,8(3):181-185.
[7] 王晓艳,方红明,王 颖,等.电针对非小细胞肺癌姑息化疗患者免疫功能的影响[J].现代实用医学,2016,28(8):1009-1011.
[8] D'Antonio C,Passaro A,Gori B,et al.Bone and brain metastasis in lung cancer:recent advances in therapeutic strategies [J].Ther Adv Med Oncol,2014,6(3):101-114.
[9] 周建红,李桂生,李高峰,等.多西他赛联合卡培他滨在晚期非小细胞肺癌二线化疗中的疗效及安全性观察[J].实用临床医药杂志,2012,16(23):100.
[10] 姜晗昉,宋国红,车 利,等.口服小剂量环磷酰胺节拍疗法治疗晚期转移性乳腺癌23例临床分析[J].中国肿瘤临床,2011,38(2):104-107.
[11] 尹 月,邱新野,刘泽源.老年非小细胞肺癌患者化疗药物治疗进展[J].中国药物应用与监测,2012,9(3):169-172.
[12] 王振华,孙桂芝.孙桂芝治疗肺癌经验内[J].辽宁中医杂志,2010,28(5):263-264.
[13] 于小伟,徐 川,李 敏,等.益气固本抗癌方联合化疗对晚期非小细胞肺癌患者肿瘤标志物、炎症因子及生活质量的影响[J].陕西中医,2016,37(7):844-845.
[14] 许先荣,赵桂芝,朱婉萍,等.紫杉醇脂质体联合中药姜黄素对小鼠转移性肺癌的影响[J].中国中医药科技,2016,23(5):551-553.
[15] 刘 健,孙增涛,刘 伟,等.益气活血解毒法对肺癌微环境作用探析[J].陕西中医,2018,39(9):1285-1287.

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备注/Memo

备注/Memo:
*国家自然科学基金资助项目(81874431)
更新日期/Last Update: 2020-03-31