[1]宋旭丹,张宪忠.五虫通络胶囊治疗后循环缺血性眩晕临床研究[J].陕西中医杂志,2021,(4):452-455.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.012]
　SONG Xudan,ZHANG Xianzhong.Study on posterior circulation ischemic vertigo treated with Wuchong Tongluo capsule[J].,2021,(4):452-455.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.012]
点击复制

五虫通络胶囊治疗后循环缺血性眩晕临床研究
分享到：

《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年4期
页码:
452-455
栏目:
临床研究
出版日期:
2021-04-05

文章信息/Info

Title:
Study on posterior circulation ischemic vertigo treated with Wuchong Tongluo capsule
作者:
宋旭丹1; 张宪忠2
(1.山东中医药大学,山东 济南 250355; 2.日照市中医医院,山东 日照 276800)
Author(s):
SONG Xudan; ZHANG Xianzhong
(Shandong University of Traditional Chinese Medicine,Ji'nan 250355,China)
关键词:
后循环缺血;  眩晕;  五虫通络胶囊;  痰瘀阻窍型;  Nε-羧甲基赖氨酸;  氧化低密度脂蛋白
Keywords:
Posterior circulation ischemic;  Vertigo;  Wuchong Tongluo capsule;  Phlegm stasis type;  N -carboxymethyl lysine;  Oxidized low density lipoprotein
分类号:
R 255.3
DOI:
DOI:10.3969/j.issn.1000-7369.2020.04.012
文献标志码:
A
摘要:
目的:观察五虫通络胶囊治疗后循环缺血(PCI)性眩晕(痰瘀阻窍型)疗效及对患者眩晕障碍量表筛查表(DHI-S)、眩晕评定量表评分系统(DARS)评分及血清Nε-羧甲基赖氨酸(CML)、氧化低密度脂蛋白(ox-LDL)水平的影响。方法:选取120例PCI性眩晕患者为对象,采用随机数字法将其分为对照组(n=60)和观察组(n=60),对照组给予甲磺酸倍他司汀治疗,观察组给予五虫通络胶囊治疗,比较两组临床疗效、中医证候积分、DHI-S和DARS评分、血清CML和ox-LDL水平、双侧椎动脉(VA)和基底动脉(BA)的平均血流速度(Vm)、全血高切黏度(HBV)、全血低切黏度(LBV)、血浆黏度(PRV)、纤维蛋白原(FIB)及不良反应发生率。结果:观察组治疗有效率高于对照组(93.33%与75.00%)(P<0.05); 治疗后观察组中医证候积分、DHI-S和DARS评分均显著低于对照组(均P<0.05); 治疗后观察组血清CML、ox-LDL水平均低于对照组(均P<0.05); 治疗后观察组VA、BA、Vm均高于对照组(均P<0.05); 治疗后观察组HBV、LBV、PRV、FIB水平均低于对照组(均P<0.05); 两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:五虫通络胶囊治疗PCI性眩晕(痰瘀阻窍型)疗效显著,可改善临床症状,降低血清CML、ox-LDL水平,改善血液流变学和血流速度,且安全性较高。
Abstract:
Objective:To observe the effects of Wuchong Tongluo capsule on the levels of N -carboxymethyl lysine(CML)and oxidized low density lipoprotein(ox-LDL)in patients with posterior circulation ischemic vertigo(phlegm stasis type)after treatment.Methods:A total of 120 cases of patients with PCI vertigo admitted as the object and divided by random number method into the control group(n=60)and the observation group(n=60).The control group was treated with betastatin mesylate and the observation group was treated with Wuchong Tongluo capsule.Clinical efficacy,TCM syndrome scores,DHI-S and DARS scores,serum CML and ox-LDL levels,bilateral vertebral artery(VA)and basilar artery(BA),whole blood high tangential viscosity(HBV),whole blood low tangential viscosity(LBV),plasma viscosity(PRV),fibrinogen(FIB),and incidence of adverse reactions.Results:The effective rate of treatment in the observation group was higher than that in the control group(93.33% vs 75.00%)(P<0.05).After treatment,the TCM syndrome score,DHI-s and DARS scores of the observation group were significantly lower than those of the control group(P<0.05).After treatment,serum levels of CML and ox-LDL in the observation group were lower than those in the control group(P<0.05).After treatment,the VA,BA and Vm in the observation group were higher than those in the control group(P<0.05).After treatment,HBV,LBV,PRV and FIB levels in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Wuchong Tongluo capsule is effective in the treatment of PCI induced vertigo(phlegm stasis type).It can improve clinical symptoms,reduce serum CML and ox-LDL levels,improve hemorheology and blood flow velocity,and is safe.

参考文献/References:

[1] 阮明军,郑 峰,伊万里,等.三参通络汤配合臭氧自血回输治疗后循环缺血性眩晕的临床研究[J].中国中医基础医学杂志,2017,40(12):1720-1723.
[2] 邵 亚,王英瑞.活血定眩汤治疗后循环缺血性眩晕的临床疗效观察[J].西部中医药,2016,29(9):113-115.
[3] 何 菊,张怀亮.后循环缺血性眩晕的中西医研究进展[J].中国中医基础医学杂志,2018,24(6):871-872.
[4] 刘雅芳,黄咏梅,戴 军,等.丁苯酞联合前列地尔注射液治疗后循环缺血性眩晕的临床效果[J].中国医药导报,2017,14(18):145-148.
[5] 邵 亚,王英瑞.活血定眩汤治疗后循环缺血性眩晕的临床疗效观察[J].西部中医药,2016,29(9):113-115.
[6] 陈灏珠.实用内科学[M].北京:人民卫生出版社,2001:93.
[7] 李国锐.中医病证诊断疗效标准[M].南京:南京大学出版社,1995:127-128.
[8] 国家食品药品监督管理局.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:171-172.
[9] 陈 鹏,薛常虎,杜 翔,等.自体血回输臭氧联合法舒地尔治疗后循环缺血性眩晕75例[J].陕西医学杂志,2016,45(9):1147-1148.
[10] 王亚婷,朱青霞.“清脑通络方”联合项三针温针治疗颈性眩晕63例临床研究[J].江苏中医药,2020,52(12):65-67.
[11] 张选国.眩晕灵治疗气虚血瘀型后循环缺血性眩晕的临床观察[J].陕西中医,2016,37(2):172-174.
[12] 魏国安,董 盛,雷根平.雷根平运用大剂量药物经验[J].中医学报,2020,35(11):2384-2387.
[13] 鞠 静,王从安.桂枝葛根汤结合针刺治疗老年人颈性眩晕的临床疗效及对预后的影响[J].中华中医药学刊,2020,38(11):154-158.
[14] 阮明军,郑 峰,伊万里.三参通络汤配合臭氧自血回输对后循环缺血性眩晕(气虚血瘀型)患者血黏度的影响[J].世界中西医结合杂志,2018,13(3):395-398,402.
[15] 席光明,李茂绪,牟 磊,等.五虫通络胶囊对脑梗死患者血液流变学指标的影响[J].吉林中医药,2019,39(3):321-323.
[16] 刘爱华,韩振翔.黄芪赤风汤合补中益气汤对气虚血瘀型后循环缺血性眩晕患者的临床疗效[J].中成药,2019,41(3):235-238.
[17] 张耀元,王立坤,常 青,等.血管性眩晕患者血清Nε-羧甲基赖氨酸、氧化低密度脂蛋白水平变化及其意义[J].山东医药,2018,58(27):54-57.
[18] 邱 惠,李卫萍,李虹伟,等.行直接PCI的急性ST段抬高型心肌梗死患者血清糖基化终末产物的水平研究[J].临床和实验医学杂志,2019,18(24):2580-2584.
[19] 王跃慧,田跃雷,梁文华,等.阿司匹林联合阿托伐他汀对缺血性脑血管病患者血清ox-LDL、炎性因子和颈动脉斑块的影响[J].河北医药,2016,38(11):1628-1631.
[20] 檀崇斌,朱 倩,甘成伟,等.替格瑞洛联合阿托伐他汀与阿司匹林在急性冠状动脉综合症经皮冠状动脉介入术术后应用效果及安全性[J].临床军医杂志,2020,48(10):1243-1245.

相似文献/References:

[1]胡萌萌,马晨超,王圆圆,等.丹参川芎嗪注射液联合前列地尔对后循环缺血性眩晕患者脑血流量及内皮功能的影响*[J].陕西中医杂志,2019,(11):1534.
　HU Mengmeng,MA Chenchao,WANG Yuanyuan,et al.Effect of Danshen ligustrazine injection combined with alprostadil on cerebral blood flow and endothelial function in patients with posterior circulation ischemic vertigo[J].,2019,(4):1534.
[2]张金钗,王连成△,杨昌宽.醒脑开窍针法联合通脉养脑汤治疗椎-基底动脉供血不足性眩晕疗效观察*[J].陕西中医杂志,2020,(7):969.[doi:DOI:10.3969/j.issn.10007369.2020.07.040]
[3]钟 路,尹胡海,黄 婕,等.从热毒学说论治高血压*[J].陕西中医杂志,2020,(8):1131.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.032]
　ZHONG Lu,YIN Huhai,HUANG Jie,et al.Treatment of hypertension by heat toxicology[J].,2020,(4):1131.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.032]
[4]李 冀,王托资,付 强.从“辰酉时”辨治高血压病探析[J].陕西中医杂志,2022,(3):338.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.016]
　LI Ji,WANG Tuozi,FU Qiang.Study on the theory of treating hypertension from “Chenyou Shi”[J].,2022,(4):338.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.016]
[5]蒋 霞.针灸结合穴位贴敷在脑动脉供血不足型眩晕患者中的应用[J].陕西中医杂志,2022,(7):950.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.034]
　JIANG Xia.Application of acupuncture and moxibustion combined with acupoint application intervention in patients with dizziness of cerebral arterial insufficiency[J].,2022,(4):950.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.034]
[6]刘川源,王 平,张德宏,等.旋提手法治疗颈椎病研究进展[J].陕西中医杂志,2023,(3):403.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.031]
　LIU Chuanyuan,WANG Ping,ZHANG Dehong,et al.Research progress on mechanism of cervical spondylosis with Xuanti Shoufa[J].,2023,(4):403.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.031]
[7]王 兴,郭 珍,杨志宏.杨志宏教授运用清心宁神汤异病同治经验[J].陕西中医杂志,2023,(6):773.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.021]
　WANG Xing,GUO Zhen,YANG Zhihong.Professor Yang Zhihong used the experience of homotherapy for heteropathy with Qingxin Ningshen decoction[J].,2023,(4):773.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.021]
[8]刘孟珍,潘秋旭,韦 斌.名中医方显明从少阳论治高血压病经验[J].陕西中医杂志,2023,(12):1783.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.026]
　LIU Mengzhen,PAN Qiuxu,WEI Bin.Professor Fang Xianming's clinical experience in treating hypertension from Shaoyang[J].,2023,(4):1783.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.026]
[9]胡兴律,王向阳,唐远山,等.定眩饮治疗后循环缺血性眩晕随机对照研究[J].陕西中医杂志,2021,(10):1375.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.012]
　HU Xinglyu,WANG Xiangyang,TANG Yuanshan,et al.A randomized controlled study of Dingxuan decotiom in the treatment of circulatory ischemic vertigo[J].,2021,(4):1375.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.012]

备注/Memo

备注/Memo:
基金项目:山东省中医药科技发展计划项目(2017-442)
更新日期/Last Update: 2021-04-09