[1]包桐,杨文莉,林欣,等.黄蜀葵花制剂-甲花片防治急性放射性心肌损伤临床研究[J].陕西中医,2025,46(11):1492-1498.[doi:DOI:10.3969/j.issn.1000-7369.2025.11.009]
　BAO Tong,YANG Wenli,LIN Xin,et al.Clinical study on prevention and treatment of acute radiation myocardial injury by Abelmoschus manihot[J].,2025,46(11):1492-1498.[doi:DOI:10.3969/j.issn.1000-7369.2025.11.009]
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黄蜀葵花制剂-甲花片防治急性放射性心肌损伤临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年11期
页码:
1492-1498
栏目:
临床研究
出版日期:
2025-11-05

文章信息/Info

Title:
Clinical study on prevention and treatment of acute radiation myocardial injury by Abelmoschus manihot
作者:
包桐1; 杨文莉1; 林欣2; 牛茹歌1; 徐中驰3; 赵云贺1
（1.南京中医药大学,江苏 南京 210023；2.南京中医药大学附属医院，江苏 南京 210029；3.南京工业大学，江苏 南京 211816)
Author(s):
BAO Tong1; YANG Wenli1; LIN Xin2; NIU Ruge1; XU Zhongchi3; ZHAO Yunhe1
(1.Nanjing University of Chinese Medicine,Nanjing 210023,China;2.Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China;3.Nanjing Technolog University,Nanjin 211816,China)
关键词:
急性放射性心肌损伤; 黄蜀葵花; 甲花片; 氧化应激; 放射治疗
Keywords:
Acute radiation-induced myocardial injury; Abelmoschus manihot; Jiahua tablet; Oxidative Stress; Radiation therapy
分类号:
R 542.2
DOI:
DOI:10.3969/j.issn.1000-7369.2025.11.009
文献标志码:
A
摘要:
目的：通过血清标志物及中医证候积分评估黄蜀葵花制剂-甲花片对急性放射性心肌损伤的保护作用及相关机制。方法：临床入组69例胸部恶性肿瘤接受放射治疗的患者，按随机数字表法分为对照组（38例）及试验组（31例）。对照组患者接受常规放射治疗及心肌保护药物治疗，试验组在此基础上加服甲花片。两组患者均在放疗前3 d及放疗后第7天检测血清指标。比较两组患者，包括可溶性ST2（sST2）、心肌肌钙蛋白Ⅰ（cTnI）、硫氧还蛋白（Trx）、硫氧还蛋白相互作用蛋白（TXNIP）、肿瘤坏死因子α（TNF-α）及同型半胱氨酸（Hcy）水平及治疗后中医证候积分水平变化。结果：治疗后，对照组sST2、cTnI、Trx、TXNIP、TNF-α及Hcy水平较干预前升高，差异有统计学意义（均P＜0.01）。试验组sST2、cTnI、Trx、TXNIP、TNF-α及Hcy水平较治疗前均有轻度升高，差异无统计学意义（P＞0.05）。组间比较，治疗前两组患者sST2、cTnI、Trx、TXNIP、TNF-α、Hcy水平比较，差异无统计学意义（均P＞0.05）。治疗后，试验组患者中医证候积分水平低于对照组，差异有统计学意义（P＜0.05）。治疗后，试验组患者sST2、cTnI、Trx、TXNIP、TNF-α及Hcy水平低于对照组，差异有统计学意义（均P＜0.05）。结论：黄蜀葵花制剂-甲花片可降低心肌损伤标志物水平，有效改善氧化应激及炎症损伤相关指标水平，改善患者中医证候，表明其对急性放射性心肌损伤具有明确的保护作用，潜在作用机制可能与抑制氧化应激反应、减轻炎症损伤相关信号通路激活有关。
Abstract:
Objective:To evaluate protective effects and underlying mechanisms of Abelmoschus manihot preparation (Jiahua Tablets) on acute radiation-induced myocardial injury through serum biomarkers and traditional Chinese medicine (TCM) syndrome scores.Methods:A total of 69 patients with thoracic malignancies receiving radiotherapy were enrolled and randomly divided into control group (n=38) and experimental group (n=31) using random number table.The control group received conventional radiotherapy and myocardial protective therapy,while the experimental group additionally took Jiahua Tablets.Serum biomarkers were measured in both groups at 3 days before radiotherapy and on the 7th day after radiotherapy.Changes in serum levels of soluble ST2 (sST2),cardiac troponin Ⅰ (cTnI),thioredoxin (Trx),thioredoxin-interacting protein (TXNIP),tumor necrosis factor-α (TNF-α),homocysteine (Hcy),and TCM syndrome scores were compared between the two groups.Results:In the control group,post-treatment levels of sST2,cTnI,Trx,TXNIP,TNF-α,and Hcy were significantly elevated compared to pre-treatment (all P＜0.01).In the experimental group,these biomarkers showed only mild increases post-treatment,with no significant differences (P＞0.05).No significant differences in pre-treatment biomarker levels (sST2,cTnI,Trx,TXNIP,TNF-α,Hcy) were observed between the two groups (all P＞0.05).Post-treatment TCM syndrome scores were significantly lower in the experimental group than in the control group (P＜0.05).Additionally,post-treatment levels of sST2,cTnI,Trx,TXNIP,TNF-α,and Hcy were markedly lower in the experimental group compared to the control group (all P＜0.05).Conclusion:Abelmoschus manihot preparation (Jiahua Tablets) significantly reduces myocardial injury biomarkers,effectively improves oxidative stress and inflammation-related indicators,and alleviates TCM syndrome scores,demonstrating a clear protective effect against acute radiation-induced myocardial injury.The potential mechanisms may involve inhibition of oxidative stress and suppression of inflammatory signaling pathway activation.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82274425）
更新日期/Last Update: 2025-11-04