[1]宗铭桐,李晴,褚雪镭,等.基于开阖枢理论防治结直肠癌肝转移[J].陕西中医,2026,(7):956-960.[doi:DOI:10.3969/j.issn.1000-7369.2026.07.017]
　ZONG Mingtong,LI Qing,CHU Xuelei,et al.Prevention and treatment of liver metastasis of colorectal cancer based on the theory of opening and closing pivot[J].,2026,(7):956-960.[doi:DOI:10.3969/j.issn.1000-7369.2026.07.017]
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基于开阖枢理论防治结直肠癌肝转移

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年7期
页码:
956-960
栏目:
学术探讨
出版日期:
2026-07-05

文章信息/Info

Title:
Prevention and treatment of liver metastasis of colorectal cancer based on the theory of opening and closing pivot
作者:
宗铭桐1; 2; 李晴2; 褚雪镭3; 薛鹏1; 朱世杰1
（1.中国中医科学院望京医院肿瘤科,北京 100102;2.北京中医药大学研究生院，北京 100029;3.中国中医科学院广安门医院肿瘤科，北京 100053)
Author(s):
ZONG Mingtong1; 2; LI Qing2; CHU Xuelei3; XUE Peng1; ZHU Shijie1
(1.Department of Oncology,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102，China;2.Graduate School of Beijing University of Chinese Medicine,Beijing 100029，China;3.Department of Oncology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053，China)
关键词:
结直肠癌; 肝转移; 开阖枢理论; 病机; 辨证论治
Keywords:
Colorectal cancer; Liver metastasis; Opening and closing pivot theory; Pathogenesis; Syndrome differentiation and treatment
分类号:
R 273
DOI:
DOI:10.3969/j.issn.1000-7369.2026.07.017
文献标志码:
A
摘要:
肝脏是结直肠癌最常见的转移部位。肝转移与局部免疫微环境改变密切相关，以免疫抑制、黏附分子增多、新血管生成为核心。中医认为其属传舍，追其源头多因肠癌三阳不利及病情迁延，导致三阴不利。从开阖枢理论出发可以认为该病的基本病机为肾枢不通、精卫失守，脾开不能、痰湿壅滞，肝阖不藏、瘀毒互结。在治疗上，应该以温煦少阴枢机、调节免疫功能，运化太阴气机开通、防止病理性细胞黏附，升发厥阴阖机、抑制血管异常新生为主要治法，方剂使用自拟方养肝益中方恢复开阖枢之功能，以改善免疫抑制、调节黏附分子、抗新血管生成，最终实现防治结直肠癌肝转移的目的。
Abstract:
The liver is the most common metastatic site of colorectal cancer.Liver metastasis is closely associated with changes in the local immune microenvironment,centered on immune suppression,increased adhesion molecules,and neovascularization.Traditional Chinese medicine (TCM) considers this condition as “transferring residence”,tracing its origin to the prolonged course of colorectal cancer due to dysfunction of the three Yang meridians,which leads to impairment of the three Yin meridians.From the perspective of the “opening and closing pivot” theory,the basic pathogenesis of this disease can be identified as:blockage of the kidney pivot leading to loss of essence and defense，failure of the spleen to open causing phlegm-dampness stagnation，and the liver’s inability to close resulting in mutual binding of stasis and toxins.In terms of treatment,the main approaches should be:warming the Shaoyin pivot to regulate immune function，promoting the transportation of Taiyin Qi to prevent pathological cell adhesion，and activating the Jueyin closing mechanism to inhibit abnormal neovascularization.The self-formulated Yanggan Yizhong decoction is used to restore the function of the opening and closing pivot.It aims to improve immune suppression,regulate adhesion molecules,and combat neovascularization,ultimately achieving the goal of preventing and treating liver metastasis of colorectal cancer.

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备注/Memo

备注/Memo:
国家自然科学基金资助面上项目（82575164）；中国中医科学院科技创新工程项目（CI12022C002-04）
更新日期/Last Update: 2026-07-10