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　QIN Ruiqi,CHEN Yinghua,SUN Wei,et al.Effects of Xingshen Tongluo Yizhi acupuncture therapy on cognitive function and serum inflammatory factors in patients with vascular dementia[J].,2026,(8):1108-1112.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.018]
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醒神通络益智针刺法对血管性痴呆患者认知功能和血清炎症因子的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年8期
页码:
1108-1112
栏目:
针灸经络
出版日期:
2026-08-05

文章信息/Info

Title:
Effects of Xingshen Tongluo Yizhi acupuncture therapy on cognitive function and serum inflammatory factors in patients with vascular dementia
作者:
秦瑞琦; 陈英华; 孙玮; 苏晓庆; 王浩宇; 苗悦
（黑龙江中医药大学附属第一医院，黑龙江 哈尔滨 150040）
Author(s):
QIN Ruiqi; CHEN Yinghua; SUN Wei; SU Xiaoqing; WANG Haoyu; MIAO Yue
（First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China）
关键词:
血管性痴呆; 醒神通络益智针刺法; 认知功能; 炎症因子; 白细胞介素10; 基质金属蛋白酶9
Keywords:
Vascular dementia; Xingshen Tongluo Yizhi acupuncture therapy; Cognitive function; Inflammatory factors; Interleukin-10; Matrix metalloproteinase-9
分类号:
R 245.31
DOI:
DOI:10.3969/j.issn.1000-7369.2026.08.018
文献标志码:
A
摘要:
目的：观察醒神通络益智针刺法对血管性痴呆（VD）患者认知功能及血清炎症因子白细胞介素-6（IL-6）、白细胞介素-10（IL-10）、基质金属蛋白酶-9（MMP-9）水平的影响。方法：选取VD患者130例，采用随机数字编号法，将患者分成观察组、对照组，每组65例。在两组均接受常规药物治疗基础上，对照组实施常规针刺法治疗，取穴百会、四神聪、双侧内关、悬钟、太溪、足三里；观察组则是采用醒神通络益智针刺法治疗，取穴百会、四神聪、情感区、双侧风池、内关、丰隆、太溪、悬钟。两组每日均治疗1次，每周5次，连续治疗8周。比较两组中医证候积分的差异，采用简易精神状态检查量表（MMSE）比较两组患者认知功能，比较血清炎症因子水平IL-6、IL-10、MMP-9差异，记录不良反应发生情况。结果：治疗后，两组中医证候积分、血清IL-6及MMP-9水平均较治疗前降低（P＜0.05），且观察组上述指标的改善程度均优于对照组（P＜0.05）。两组MMSE评分及血清IL-10水平均较治疗前升高，且观察组升高幅度大于对照组（P＜0.05）。安全性方面，观察组出现内关穴局部疼痛1例（1.54%），对照组出现血肿1例（1.54%），两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：醒神通络益智针刺法能有效改善VD患者的中医证候与认知功能，调节血清IL-6、IL-10、MMP-9水平，且安全性较好，其疗效机制可能与调控炎症反应有关。
Abstract:
Objective:To observe effects of Xingshen Tongluo Yizhi acupuncture method on cognitive function and serum inflammatory factors interleukin-6 (IL-6),interleukin-10 (IL-10)，and matrix metalloproteinase-9 (MMP-9) levels in patients with vascular dementia (VD).Methods:A total of 130 VD patients were selected and randomly divided into observation group and control group，with 65 cases in each group.Both groups received conventional drug treatment.The control group were treated with conventional acupuncture at Baihui，Sishencong，bilateral Neiguan，Xuanzhong，Taixi，and Zusanli.The observation group were treated with Xingshen Tongluo Yizhi acupuncture method at Baihui，Sishencong，Affective Zone，bilateral Fengchi，Neiguan，Fenglong，Taixi and Xuanzhong.Both groups were treated once daily，five times a week，for eight consecutive weeks.The differences in TCM syndrome scores，cognitive function as measured by the mini-mental state examination (MMSE)，and serum levels of IL-6，IL-10，and MMP-9 were compared between the two groups.Adverse reactions were also recorded.Results:After treatment，the TCM syndrome scores and serum levels of IL-6 and MMP-9 in both groups were significantly lower than those before treatment (P＜0.05)，and improvement in the observation group was better than that in the control group (P＜0.05).MMSE scores and serum IL-10 levels in both groups were significantly higher than those before treatment，and the increase in the observation group were greater than those in the control group (P＜0.05).In terms of safety，one case (1.54%) in the observation group experienced local pain at Neiguan acupoint，and one case (1.54%) in the control group developed a hematoma.There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion:Xingshen Tongluo Yizhi acupuncture method can effectively improve TCM syndrome and cognitive function of VD patients，regulate serum levels of IL-6，IL-10，and MMP-9，and has better safety.Its therapeutic mechanism may be related to the regulation of inflammatory responses.the regulation of inflammatory response,which has certain clinical promotion value.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目（82474650）;黑龙江省自然科学基金资助项目（ZD2021H007）;黑龙江省中医药科研项目（ZHY2023-189,ZHY2023-209,ZHY2024-090,ZYW2024-112）
更新日期/Last Update: 2026-08-13