[1]张亚南,徐志云.针灸联合耳穴揿针治疗老年高血压合并缺血性卒中认知功能障碍疗效研究[J].陕西中医,2026,(8):1125-1129.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.021]
　ZHANG Yanan,XU Zhiyun.Efficacy study on acupuncture combined with auricular point embedding needle in elderly hypertensive patients complicated with ischemic stroke and cognitive dysfunction[J].,2026,(8):1125-1129.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.021]
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针灸联合耳穴揿针治疗老年高血压合并缺血性卒中认知功能障碍疗效研究

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年8期
页码:
1125-1129
栏目:
针灸经络
出版日期:
2026-08-05

文章信息/Info

Title:
Efficacy study on acupuncture combined with auricular point embedding needle in elderly hypertensive patients complicated with ischemic stroke and cognitive dysfunction
作者:
张亚南; 徐志云
（南通市第二人民医院，江苏 南通 226002）
Author(s):
ZHANG Yanan; XU Zhiyun
(Nantong Second People’s Hospital,Nantong 226002，China)
关键词:
高血压; 缺血性卒中; 针灸; 耳穴揿针; 认知功能; 氧化应激; 同型半胱氨酸; 中枢神经递质
Keywords:
Hypertension; Ischemic stroke; Acupuncture; Auricular point press needle; Cognitive function; Oxidative stress; Homocysteine; Central neurotransmitters
分类号:
R 544.1
DOI:
DOI:10.3969/j.issn.1000-7369.2026.08.021
文献标志码:
A
摘要:
目的：探讨针灸联合耳穴揿针治疗对老年高血压合并缺血性卒中（IS）认知功能障碍患者氧化应激、同型半胱氨酸（Hcy）和中枢神经递质水平影响。方法：选择高血压合并IS认知功能障碍患者76例，采用简单随机数字表法将患者随机分为对照组、观察组，各38例。对照组采取常规治疗和认知功能训练，观察组在对照组基础上采用针灸联合耳穴揿针治疗，两组均治疗12周。比较两组治疗前后氧化应激和Hcy水平，中枢神经递质水平，蒙特利尔认知评估量表（MoCA）评分和功能独立性评定量表（FIM），韦氏记忆量表Ⅳ中文版（成人版）（WMS-Ⅳ）量表评分变化。结果：两组治疗后血清超氧化物歧化酶（SOD）、多巴胺（DA）、乙酰胆碱（ACh）和γ- 氨基丁酸（GABA）水平高于治疗前，而丙二醛（MDA）和Hcy水平低于治疗前（P＜0.05）。观察组治疗后血清SOD、DA、ACh和GABA水平高于对照组，而MDA和Hcy水平低于对照组（P＜0.05）。两组治疗后MoCA量表和功能独立性评定量表（FIM）评分高于治疗前（P＜0.05）。观察组治疗后MoCA量表和FIM量表评分高于对照组（P＜0.05）。两组治疗后工作记忆、视觉记忆和听觉记忆评分高于治疗前（P＜0.05）。观察组治疗后工作记忆、视觉记忆和听觉记忆评分高于对照组（P＜0.05）。结论：针灸联合耳穴揿针治疗对老年高血压合并IS认知功能障碍患者效果较好，可减轻患者氧化应激反应，降低Hcy水平，调控中枢神经递质水平。
Abstract:
Objective:To investigate effects of acupuncture combined with ear acupressure needles on oxidative stress,homocysteine (Hcy),and central neurotransmitter levels in elderly patients with hypertension complicated by ischemic stroke (IS) and cognitive impairment.Methods:A total of 76 patients with hypertension and IS-related cognitive impairment were randomly divided into control group and observation group,each comprising 38 cases,using simple random number table method.The control group received standard treatment and cognitive training,while the observation group received acupuncture combined with ear acupressure needles in addition to standard treatment.Both groups were treated for 12 weeks.Changes in oxidative stress and Hcy levels,central neurotransmitter levels,Montreal cognitive assessment(MoCA) scores,functional independence measure (FIM) scores,and wechsler memory scale Ⅳ Chinese version (adult edition) (WMS-Ⅳ) scores before and after treatment were compared between the two groups.Results:After treatment,serum superoxide dismutase (SOD),dopamine (DA),acetylcholine (ACh),and γ-aminobutyric acid (GABA) levels were higher than pre-treatment levels,while malondialdehyde (MDA) and Hcy levels were lower (P＜0.05).In the observation group,post-treatment serum SOD,DA,ACh,and GABA levels were significantly higher than those in the control group,whereas MDA and Hcy levels were significantly lower (P＜0.05).MoCA and FIM scores improved significantly after treatment in both groups compared to baseline (P＜0.05),and the observation group showed higher MoCA and FIM scores than the control group (P＜0.05).Working memory,visual memory,and auditory memory scores also improved significantly after treatment in both groups (P＜0.05),with the observation group showing higher scores than the control group (P＜0.05).Conclusion:Acupuncture combined with ear acupressure needles was effective in treating elderly patients with hypertension and IS-related cognitive impairment,helping to reduce oxidative stress,lower Hcy levels,and regulate central neurotransmitter levels.

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备注/Memo

备注/Memo:
江苏省中医药管理局科研基金资助项目（MS20231114）；江苏省南通市社会民生科技计划项目（MSZ2024093）
更新日期/Last Update: 2026-08-13