[1]杜思鸿,秦文鹏,闫硕,等.石菖蒲常见药对防治阿尔茨海默病机制研究进展[J].陕西中医,2026,(8):1137-1142.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.023]
　DU Sihong,QIN Wenpeng,YAN Shuo,et al.Research progress on mechanism of commonly used medicinal pairs of acorus tatarinowii in prevention and treatment of Alzheimer’s disease[J].,2026,(8):1137-1142.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.023]
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石菖蒲常见药对防治阿尔茨海默病机制研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年8期
页码:
1137-1142
栏目:
综述
出版日期:
2026-08-05

文章信息/Info

Title:
Research progress on mechanism of commonly used medicinal pairs of acorus tatarinowii in prevention and treatment of Alzheimer’s disease
作者:
杜思鸿1; 秦文鹏1; 闫硕1; 何江龙1; 崔书克1; 2
（1.河南中医药大学，河南 郑州450000；2.河南中医药大学第三附属医院，河南 郑州450003）
Author(s):
DU Sihong1; QIN Wenpeng1; YAN Shuo1; HE Jianglong1; CUI Shuke1; 2
（1.Henan University of Chinese Medicine,Zhengzhou 450000,China;2.The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhenghzhou 450003,China）
关键词:
石菖蒲; 阿尔茨海默病; 药对; 药理机制; 神经保护; 信号通路
Keywords:
Acorus tatarinowii; Alzheimer’s disease; Drug combination; Pharmacological mechanism; Neuroprotection; Signaling pathway
分类号:
R 28
DOI:
DOI:10.3969/j.issn.1000-7369.2026.08.023
文献标志码:
A
摘要:
阿尔茨海默病（AD）是一种以认知功能障碍为主要表现的中枢神经系统退行性疾病，目前现代医学干预效果有限。石菖蒲具有开窍豁痰、醒神益智之效，其防治阿尔茨海默病的作用机制涉及抗神经炎症、抗氧化应激、调节胆碱能系统、拮抗Aβ与Tau病理、抑制神经细胞凋亡与调节自噬、调节肠道菌群等多个环节。在临床应用中，石菖蒲常与远志、川芎、人参、五味子、益智仁、何首乌、熟地黄、茯苓等药物配伍，针对痰浊蒙窍、瘀血阻络、气虚痰阻等不同证型发挥协同增效作用。
Abstract:
Alzheimer’s disease (AD) was a degenerative disease of central nervous system characterized by cognitive dysfunction.Currently,the effect of modern medical intervention was limited.Acorus tatarinowii had effects of opening orifices,resolving phlegm,awakening mind and enhancing intelligence.Its mechanism of action in preventing and treating Alzheimer’s disease involves multiple aspects such as anti-neuroinflammation,anti-oxidative stress,regulation of cholinergic system,antagonism of Aβ and Tau pathology,inhibition of neuronal apoptosis and regulation of autophagy,and regulation of the intestinal flora.In clinical application,Acorus tatarinowii was often combined with polygala tenuifolia,ligusticum Chuanxiong,Ginseng,Schisandra chinensis,alpinia oxyphylla,polygonum multiflorum,rehmannia glutinosa,and poria cocos,etc.To exert a synergistic effect in treating different syndrome types such as phlegm turbidity obscuring orifices,blood stasis blocking collaterals,and Qi deficiency with phlegm obstruction.

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备注/Memo

备注/Memo:
国家中医药管理局科技项目（GZY-KJS-2023-010）；河南省特色骨干学科中医学学科建设项目（STG-ZYX03-202130）；河南中医药大学横向课题（HZY2020001）
更新日期/Last Update: 2026-08-13