[1]郝圣阳,杨娅妮,马鹏程,等.龙牡安神方治疗冠心病PCI术后心胆气虚型焦虑抑郁研究进展[J].陕西中医,2026,(8):1143-1148.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.024]
　HAO Shengyang,YANG Yani,MA Pengcheng,et al.Research progress on Longmu Anshen formula for treating anxiety and depression of heart and gallbladder Qi deficiency type after PCI in coronary heart disease[J].,2026,(8):1143-1148.[doi:DOI:10.3969/j.issn.1000-7369.2026.08.024]
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龙牡安神方治疗冠心病PCI术后心胆气虚型焦虑抑郁研究进展

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年8期
页码:
1143-1148
栏目:
综述
出版日期:
2026-08-05

文章信息/Info

Title:
Research progress on Longmu Anshen formula for treating anxiety and depression of heart and gallbladder Qi deficiency type after PCI in coronary heart disease
作者:
郝圣阳1; 杨娅妮1; 马鹏程2; 彭晓明2
（1.甘肃中医药大学中西医结合学院，甘肃 兰州 730030；2.甘肃中医药大学附属医院脑病科，甘肃 兰州 730030）
Author(s):
HAO Shengyang1; YANG Yani1; MA Pengcheng2; PENG Xiaoming2
（1.Integrated Traditional Chinese and Western Medicine College，Gansu University of Chinese Medicine,Lanzhou 730030,China；2.Department of Encephalopathy,Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730030,China）
关键词:
龙牡安神方; PCI术后; 心胆气虚; 焦虑抑郁; 心胆同治
Keywords:
Longmu Anshen formula; Post-PCI; Heart and gallbladder Qi deficiency; Anxiety and depression; Integrated treatment of heart and gallbladder
分类号:
R 541.4
DOI:
DOI:10.3969/j.issn.1000-7369.2026.08.024
文献标志码:
A
摘要:
经皮冠状动脉介入治疗（PCI）是冠心病血运重建的重要手段，但术后焦虑抑郁高，是不可忽视的临床问题。2014年《经皮冠状动脉介入治疗手术前后抑郁和（或）焦虑中医诊疗专家共识》将PCI术后焦虑抑郁归为中医“郁证”范畴，其中“心胆气虚证”是核心证型之一。龙牡安神方以龙骨、牡蛎为君药，配伍酸枣仁等安神定志之品，深合“心胆同治、形神共调”之旨。基于“心胆相通”理论，梳理PCI术后心胆气虚证的病机演变与证候特征，解析龙牡安神方的组方原理与药对配伍内涵，结合实验研究与临床证据，探讨其通过调节神经炎症、平衡脑内神经递质、调控应激反应轴及脑肠轴等多途径,发挥抗焦虑抑郁效应的中医机制与现代诠释，为该方的临床推广与深入研究提供理论依据。
Abstract:
Percutaneous coronary intervention (PCI) was crucial revascularization approach for coronary artery disease,high incidence of postoperative anxiety and depression has become an undeniable clinical concern.The 2014 expert consensus on traditional Chinese medicine diagnosis and treatment of depression and/or anxiety before and after PCI explicitly classified post-PCI anxiety and depression as belonging to the TCM syndrome category of Yuzheng(depression syndrome),with Heart-Gallbladder Qi deficiency syndrome being one of its core patterns.Longmu Anshen formula primarily composed of Dragon’s bone and oyster as key ingredients,combined with calming agents such as Ziziphus Jujuba seed,closely aligns with principle of treating both heart and gallbladder while harmonizing body and mind.Based on classical theory of interconnection between heart and gallbladder.This study systematically reviews pathogenic evolution and clinical characteristics of Heart-Gallbladder Qi deficiency dyndrome following PCI,analyzes formulation principles and herbal pairings of Longmu Anshen formula,and integrates experimental research and clinical evidence to explore its mechanisms in alleviating anxiety and depression through multiple pathways-such as modulating neuroinflammation,balancing neurotransmitters in the brain,and regulating the stress response axis and gut-brain axis—from both traditional Chinese medicine and modern perspectives.To provide theoretical support for clinical application and further research of this formula.

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备注/Memo

备注/Memo:
甘肃省中医药管理局科技项目（GZKG-2024-59）；甘肃省自然科学基金资助项目（24JRRA1039）
更新日期/Last Update: 2026-08-13