[1]刘 芳,张立祥,王慧敏,等.养生益肾汤对糖尿病肾病患者血清细胞因子水平及肾功能的影响[J].陕西中医,2022,(4):476-478,486.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.016]
　LIU Fang,ZHANG Lixiang,WANG Huimin,et al.Effect of Yangsheng Yishen decoction on serum cytokine level and renal function in patients with diabetic nephropathy[J].,2022,(4):476-478,486.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.016]
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养生益肾汤对糖尿病肾病患者血清细胞因子水平及肾功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年4期
页码:
476-478,486
栏目:
临床研究
出版日期:
2022-04-05

文章信息/Info

Title:
Effect of Yangsheng Yishen decoction on serum cytokine level and renal function in patients with diabetic nephropathy
作者:
刘 芳; 张立祥; 王慧敏; 李 越
(唐山市中医医院西院区肾病二科,河北 唐山 063000)
Author(s):
LIU Fang; ZHANG Lixiang; WANG Huimin; LI Yue
(The Second Department of Nephrology,West Campus,Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000,China)
关键词:
糖尿病肾病;  养生益肾汤;  厄贝沙坦;  细胞因子;  肾功能;  尿白蛋白排泄率
Keywords:
Diabetic nephropathy;  Yangsheng Yishen decoction;  Irbesartan;  Cytokines;  Renal function;  Urinary albumin excretion rate
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2022.04.016
文献标志码:
A
摘要:
目的:分析养生益肾汤对糖尿病肾病患者血清细胞因子水平及肾功能的影响。方法:将98例糖尿病肾病患者分为对照组、观察组,各49例。对照组口服厄贝沙坦,观察组采用厄贝沙坦联合养生益肾汤进行治疗,两组均治疗3个月。比较两组治疗3个月后的疗效,统计两组治疗前和治疗3个月后血糖代谢指标、血脂代谢指标、肾功能及血清细胞因子水平。结果:治疗3个月后,观察组总有效率高于对照组(P<0.05)。治疗前与治疗3个月后比较,观察组血清血糖代谢指标水平降低,且低于对照组(P<0.05)。治疗前与治疗3个月后比较,两组血清低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)、血肌酐(Scr)、血清细胞因子水平及尿白蛋白排泄率(UAER)降低,观察组均低于对照组(P<0.05)。治疗前与治疗3个月后比较,观察组血清高密度脂蛋白胆固醇(HDL-C)水平及肾小球滤过率(eGFR)升高,且均高于对照组(P<0.05)。结论:养生益肾汤可有效改善糖尿病肾病患者血糖代谢、血脂代谢情况、肾功能及疾病相关细胞因子的合成分泌。
Abstract:
Objective:To analyze the effects of Yangsheng Yishen decoction on serum cytokines and renal function in patients with diabetic nephropathy.Methods:A total of 98 patients with diabetic nephropathy were randomly divided into control group and observation group,with 49 cases in each group by random number table method.The control group received oral irbesartan,and the observation group received irbesartan combined with health-nourishing kidney decoction.The therapeutic effects of the two groups were compared after 3 months of treatment,and the levels of blood glucose metabolism,blood lipid metabolism,renal function and serum cytokine in the two groups were counted before treatment and after 3 months of treatment.Results:After 3 months of treatment,the total effective rate of observation group was higher than that of control group(P<0.05).Compared with before treatment,the levels of serum fasting blood glucose(FBG),2 h blood glucose(2 h PBG)and glycosylated hemoglobin(HbA1c)in the observation group decreased after 3 months of treatment,and which were lower than those in the control group(P<0.05).Compared with those before treatment,the levels of serum low density lipoprotein cholesterol(LDL-C),triglyceride(TG),total cholesterol(TC),serum creatinine(Scr),transforming growth factor-β(TGF-β),platelet-derived growth factor(PDGF),vascular endothelial growth factor(VEGF)and urinary albumin excretion rate(UAER)decreased after 3 months of treatment in both groups,and the observation group were lower than those in the control group(P<0.05).Compared with before treatment,the levels of serum high density lipoprotein cholesterol(HDL-C)and the glomerular filtration rate(eGFR)in observation group increased after 3 months of treatment,and which was higher than that in control group(P<0.05).Conclusion:Yangsheng Yishen decoction could effectively improve the synthesis and secretion of blood glucose metabolism,blood lipid metabolism,renal function and disease-related cytokines,and had a better clinical effect.

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备注/Memo

备注/Memo:
基金项目:河北省中医药管理局科研项目(2018323)
更新日期/Last Update: 2022-04-08