[1]谢东明,黄治胜,罗 巧.丹芪祛瘀止痛汤对慢性萎缩性胃炎患者血清胃蛋白酶原及相关指标的影响[J].陕西中医,2022,(4):487-491.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.019]
　XIE Dongming,HUANG Zhisheng,LUO Qiao.Effect of Danqi Quyu Zhitong decoction on serum PGⅠ,PGⅡ and serum related indexes in patients with chronic atrophic gastritis[J].,2022,(4):487-491.[doi:DOI:10.3969/j.issn.1000-7369.2022.04.019]
点击复制

丹芪祛瘀止痛汤对慢性萎缩性胃炎患者血清胃蛋白酶原及相关指标的影响
分享到：

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2022年4期
页码:
487-491
栏目:
临床研究
出版日期:
2022-04-05

文章信息/Info

Title:
Effect of Danqi Quyu Zhitong decoction on serum PGⅠ,PGⅡ and serum related indexes in patients with chronic atrophic gastritis
作者:
谢东明1; 黄治胜2; 罗 巧1
(1.成都中医药大学附属医院,四川 成都 610075; 2.简阳市中医医院,四川 简阳 641400)
Author(s):
XIE Dongming; HUANG Zhisheng; LUO Qiao
(Affiliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
关键词:
慢性萎缩性胃炎;  丹芪祛瘀止痛汤;  胃蛋白酶原Ⅰ;  胃蛋白酶原Ⅱ;  胃泌素17;  肿瘤坏死因子-α;  白细胞介素1β
Keywords:
Chronic atrophic gastritis;  Danqi Quyu Zhitong decoction;  Pepsinogen I;  Pepsinogen Ⅱ;  Gastrin 17;  Tumor necrosis factor-α;  Interleukin 1β
分类号:
R 573.32
DOI:
DOI:10.3969/j.issn.1000-7369.2022.04.019
文献标志码:
A
摘要:
目的:探讨丹芪祛瘀止痛汤对慢性萎缩性胃炎患者血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)及血清相关指标的影响。方法:以90例慢性萎缩性胃炎患者为研究对象,按随机数字表法分为对照组(45例,给予四联杀菌方治疗)和研究组(45例,在对照组治疗的基础上给予丹芪祛瘀止痛汤治疗)。观察两组治疗后临床疗效及不良反应,对比治疗前后中医证候积分、胃黏膜血流量、PGⅠ、PGⅡ、胃泌素17(G-17)、肿瘤坏死因子-α(TNF-α)、白细胞介素1β(IL-1β)、表皮生长因子(EGF)水平。结果:治疗前,两组胃脘隐痛且痛有定处拒按、夜间疼痛明显、嗳气吐酸、口干发苦、乏力、食少、便溏、胃窦小弯、胃窦前壁、胃窦大弯、胃窦后壁的血流量、PGⅠ、PGⅡ、G-17、TNF-α、IL-1β、EGF水平比较,差异均无统计学意义(P>0.05); 治疗后,两组胃脘隐痛且痛有定处拒按、夜间疼痛明显、嗳气吐酸、口干发苦、乏力、食少、便溏、PGⅠ、G-17、TNF-α、IL-1β水平均较治疗前降低,胃窦小弯、胃窦前壁、胃窦大弯、胃窦后壁的血流量较治疗前更快,PGⅡ、EGF水平较治疗前升高,与对照组相比,研究组临床疗效、胃脘隐痛且痛有定处拒按、夜间疼痛明显、嗳气吐酸、口干发苦、乏力、食少、便溏、PGⅠ、G-17、TNF-α、IL-1β水平更低,胃窦小弯、胃窦前壁、胃窦大弯、胃窦后壁的血流量更快,PGⅡ、EGF水平更高,差异均有统计学意义(P<0.05)。在治疗过程中,两组均未出现不良反应。结论:丹芪祛瘀止痛汤能够有效改善慢性萎缩性胃炎患者临床症状,且能够调节胃黏膜血流量、血清PGⅠ、PGⅡ及血清相关指标水平,可在临床应用。
Abstract:
Objecive:To investigate the effect of Danqi Quyu Zhitong decoction on serum PGⅠ,PGⅡ and serum related indexes in patients with chronic atrophic gastritis Methods:Taking 90 patients with chronic atrophic gastritis as the research objects,they were divided into control group(45 cases treated with Silian Sterilization decoction)and study group according to the random number table method(45 cases were treated with Danqi Quyu Zhitong decoction on the basis of the treatment of the control group).Observed the clinical efficacy and adverse reactions of the two groups after treatment,and compared the TCM syndrome scores,gastric mucosal blood flow,pepsinogen I(PGⅠ),pepsinogen Ⅱ(PGⅡ),and gastrin 17(G-17)before and after treatment.Tumor necrosis factor-α(TNF-α),interleukin 1β(IL-1β),epidermal growth factor(EGF)levels.Results:Before treatment,the two groups of gastric cavity had dull pain and pain at fixed locations,obvious pain at night,belching and vomiting acid,dry mouth,bitterness,fatigue,lack of food,loose stools,small curvature of gastric antrum,anterior wall of gastric antrum,large gastric antrum,there was no significant difference in blood flow,PGⅠ,PGⅡ,G-17,TNF-α,IL-1β,and EGF levels in the posterior wall of the gastric antrum(P>0.05).After treatment,the two groups had dull gastric pain and pain was fixed and refused to press,pain at night was obvious,belching and vomiting acid,dry mouth,bitterness,fatigue,lack of food,loose stools,PGⅠ,G-17,TNF-α,IL-1β levels were lower than before treatment,gastric antrum the blood flow of the minor curvature,the anterior wall of the gastric antrum,the greater curvature of the gastric antrum,and the posterior wall of the gastric antrum were faster than before treatment,and the levels of PGⅡ and EGF were higher than those before treatment.Compared with the control group,the study group had clinical efficacy and dull gastric pain in addition,the pain was fixed and refused to press,the pain was obvious at night,belching and vomiting acid,dry mouth and bitterness,fatigue,lack of food,loose stools,lower levels of PGⅠ,G-17,TNF-α,IL-1β,and small curvature of the gastric antrum the blood flow in the anterior wall of the gastric antrum,the greater curvature of the gastric antrum,and the posterior wall of the gastric antrum was faster,and the levels of PGⅡ and EGF were higher.The difference was statistically significant(P<0.05).During the treatment,no adverse reactions occurred in the two groups.Conclusion: Danqi Quyu Zhitong decoction can effectively improve the clinical symptoms of patients with chronic atrophic gastritis,and can regulate the gastric mucosal blood flow,serum PGⅠ,PGⅡ and serum related index levels,and can be popularized and applied in clinical practice.

参考文献/References:

[1] 李志更,李玉波,王俊文,等.慢性萎缩性胃炎中医证候分布频率的Meta分析[J].中国中西医结合杂志,2020,40(1):52-58.
[2] 林 玲,韩 涛,陆 璐,等.慢性萎缩性胃炎及胃癌前病变动物模型的总结应用与评述[J].中国实验方剂学杂志,2019,25(2):220-227.
[3] 杜 亮,吴学勇,吴 伟.慢性萎缩性胃炎与胃镜、胃黏膜病理及幽门螺旋杆菌感染的相关性研究[J].陕西医学杂志,2017,46(12):1676-1677.
[4] 刘怀智,周海娟,陈 刚.健脾消萎方联合西药治疗慢性萎缩性胃炎疗效研究[J].陕西中医,2020,41(12):1767-1769.
[5] 雷 琼,曹海芳,王芝林,等.香砂养胃丸联合替普瑞酮胶囊治疗慢性萎缩性胃炎的疗效观察[J].陕西中医,2018,39(1):71-73.
[6] 王炳予,袁星星,杨 磊,等.丹芪祛瘀止痛颗粒治疗气虚血瘀型慢性萎缩性胃炎疗效及对炎性因子和细胞因子的影响[J].现代中西医结合杂志,2017,26(30):3314-3317.
[7] 中华医学会消化病学分会.中国慢性胃炎共识意见[J].胃肠病学,2006,11(11):674-682.
[8] 国家食品药品监督管理局.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:124-129.
[9] 王 阳.基于络病理论探析慢性萎缩性胃炎“气络失和、毒损血络”病机[J].陕西中医,2020,41(11):1632-1634,1638.
[10] 付利然,张士金,郭伟胜.益气化瘀解毒方对慢性萎缩性胃炎癌前病变的疗效及对细胞周期蛋白E表达和肿瘤标记物的影响[J].中华中医药学刊,2017,35(10):256-258.
[11] 汤秋芳,廖郁文,沈智理.加味六君子汤治疗气虚血瘀型慢性萎缩性胃炎临床观察[J].山西中医,2020,36(7):7-9.
[12] 王国庆,刘红军,梁素芳.益气活血方联合三联疗法对气虚血瘀型慢性萎缩性胃炎患者炎性反应和血液流变学的影响[J].世界中医药,2019,14(1):182-186.
[13] 吴 晋.替普瑞酮治疗老年HP阳性慢性萎缩性胃炎临床效果分析[J].陕西医学杂志,2021,50(6):735-737,762.
[14] Bang CS,Lee JJ,Baik GH.Prediction of chronic atrophic gastritis andgastric neoplasms by serum pepsinogen assay:A systematic review and meta-analysis of diagnostic test accuracy[J].J Clin Med,2019,8(5):657.
[15] 陈亚军,罗 俊,韩 怡.胃蛋白酶原1、G-17、HP-IgG检测结合胃黄色素瘤对诊断萎缩性胃炎准确性分析[J].分子诊断与治疗杂志,2021,13(4):547-550.
[16] 王晓楠,张亚峰.慢性萎缩性胃炎的诊治进展[J].中南医学科学杂志,2020,48(3):323-326.
[17] 高 洁.胃蛋白酶原、胃泌素-17在慢性萎缩性胃炎中的表达及其与幽门螺杆菌感染相关性分析[J].陕西医学杂志,2019,48(1):131-134.
[18] Wei X,Feng XP,Wang LY,et al.Improved methodfor inducing chronic atrophic gastritis in mice[J].World J Gastrointest Oncol,2019,11(12):1115-1125.
[19] 李德成,张守菊,李 霞.胃炎宁颗粒联合维酶素治疗慢性萎缩性胃炎的临床研究[J].现代药物与临床,2019,34(5):1379-1383.
[20] 王雪梅,严光俊,刘 冲.半夏泄心汤加减治疗脾胃湿热型慢性萎缩性胃炎患者的临床效果[J].世界中医药,2019,14(2):171-175.
[21] 娄莹莹,李佃贵,霍永利,等.化浊解毒和胃方对慢性萎缩性胃炎患者VEGF、EGF及Th1/Th2平衡的影响[J].中国医药导报,2020,17(4):143-146.(收稿:2021-09-30)

相似文献/References:

[1]孙明明,李 聪,史 林.王庆国教授对慢性萎缩性胃炎的治疗经验探析[J].陕西中医,2019,(2):260.
　SUN Mingming,LI Cong,SHI Lin..Analysis on the treatment experience of chronic atrophic gastritis by professor WANG Qingguo[J].,2019,(4):260.
[2]钱元霞,汤玲珺,钱 祯,等.四逆散对慢性萎缩性胃炎癌前病变大鼠的作用及机制研究*[J].陕西中医,2019,(8):990.
　QIAN Yuanxia,TANG Lingjun,QIAN Zhen,et al.The effect of Sinisan on the rats of precancerous lesion of chronic atrophic gastritis and its mechanism[J].,2019,(4):990.
[3]闫 强,杨国强 △.健脾清胃汤治疗脾胃虚弱型慢性萎缩性胃炎疗效及对患者免疫功能的影响[J].陕西中医,2019,(8):1014.
　YAN Qiang,YANG Guoqiang..Effect of Jianpi Qingwei decoction on chronic atrophic gastritis of spleen and stomach deficiency and its influence on patients' immune function[J].,2019,(4):1014.
[4]杨宏升.安胃活血汤联合序贯法治疗慢性萎缩性胃炎胃癌前病变疗效研究[J].陕西中医,2019,(9):1195.
　YANG Hongsheng..Effect of Anwei Huoxue decoction combined with sequential therapy on gastric precancerous lesions of chronic atrophic gastritis[J].,2019,(4):1195.
[5]马佳乐 ,李慧臻.中医治疗慢性萎缩性胃炎研究进展*[J].陕西中医,2019,(11):1646.
　MA Jiale,LI Huizhen..Traditional Chinese medicine in the treatment of chronic atrophic gastritis[J].,2019,(4):1646.
[6]曾微微,麦联任,张 玲,等.健胃益脾汤治疗慢性萎缩性胃炎疗效及对患者胃蛋白酶原的影响*[J].陕西中医,2020,(11):1548.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.008]
　ZENG Weiwei,MAI Lianren,ZHANG Ling,et al.Effect of Jianwei Yipi decoction on treating chronic atrophic gastritis and its influence on pepsinogen[J].,2020,(4):1548.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.008]
[7]王 阳.基于络病理论探析慢性萎缩性胃炎“气络失和,毒损血络”病机*[J].陕西中医,2020,(11):1632.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.030]
　WANG Yang..Analysis of pathogenesis of chronic atrophic gastritis based on collateral disease theory[J].,2020,(4):1632.[doi:DOI:10.3969/j.issn.1000-7369.2020.11.030]
[8]张紫涵,陈 俊,徐 丹.苦参碱联合胃复春片治疗慢性萎缩性胃炎疗效及对患者血清胃蛋白酶原亚群的影响[J].陕西中医,2021,(3):323.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.013]
　ZHANG Zihan,CHEN Jun,XU Dan.Effect of matrine combined with Weifuchun tablet on efficacy and serum pepsinogen subgroup in patients with chronic atrophic gastritis[J].,2021,(4):323.[doi:DOI:10.3969/j.issn.1000-7369.2020.03.013]
[9]寇 媛,闻新丽,薛 峰.养胃清热化瘀汤治疗慢性萎缩性胃炎及癌前病变临床研究[J].陕西中医,2021,(9):1233.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.021]
　KOU Yuan,WEN Xinli,XUE Feng.Clinical study on Yangwei Qingre Huayu decoction in treatment of chronic atrophic gastritis and precancerous lesions[J].,2021,(4):1233.[doi:DOI:10.3969/j.issn.1000-7369.2020.09.021]
[10]张 鹏,于 勇,万 强,等.补虚养胃汤加减治疗慢性萎缩性胃炎疗效及对患者胃肠功能的影响[J].陕西中医,2022,(1):66.[doi:DOI:10.3969/j.issn.1000-7369.2022.01.016]

备注/Memo

备注/Memo:
基金项目:四川省中医药管理局资助项目(2019A035)
更新日期/Last Update: 2022-04-08