[1]刘 晶,沈宝华,冉颖卓.益肾固摄活血通络法治疗肾虚血瘀型糖尿病肾病临床疗效[J].陕西中医,2023,(4):446-450.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.008]
　LIU Jing,SHEN Baohua,RAN Yingzhuo.Clinical effect of Yishen Gushe,Huoxue Tongluo method on diabetic nephropathy of kidney deficiency and blood stasis type[J].,2023,(4):446-450.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.008]
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益肾固摄活血通络法治疗肾虚血瘀型糖尿病肾病临床疗效
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年4期
页码:
446-450
栏目:
临床研究
出版日期:
2023-04-05

文章信息/Info

Title:
Clinical effect of Yishen Gushe,Huoxue Tongluo method on diabetic nephropathy of kidney deficiency and blood stasis type
作者:
刘 晶; 沈宝华; 冉颖卓
(南京中医药大学附属南京中医院,江苏 南京 210022)
Author(s):
LIU Jing; SHEN Baohua; RAN Yingzhuo
(Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,China)
关键词:
糖尿病肾病;  肾虚血瘀;  尿蛋白;  同型半胱氨酸;  血清胱抑素C
Keywords:
Diabetic nephropathy;  Kidney deficiency and blood stasis;  Urinary protein;  Homocysteine;  Cystatin C
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2023.04.008
文献标志码:
A
摘要:
目的:观察益肾固摄活血通络法治疗肾虚血瘀型早期糖尿病肾病的临床疗效。方法:将110例肾虚血瘀型早期糖尿病肾病患者随机分为对照组和观察组,每组各55例。对照组采用糖尿病肾病基础治疗,观察组在对照组基础上,加用益肾固摄活血通络中药治疗,疗程均为2个月。比较两组治疗前后的中医症候评分、糖代谢、肾功能、尿蛋白指标的变化,评价两组总体临床疗效及安全性。结果:治疗2个月后,观察组总有效率为85.45%,对照组为63.64%,观察组总有效率显著高于对照组(P<0.05)。治疗后,两组中医症候评分、空腹血糖、餐后2 h血糖、糖化血红蛋白、同型半胱氨酸(Hcy)、血清胱抑素C(CysC)、尿蛋白相关指标均较治疗前改善(均P<0.05),且观察组中医症候评分、糖化血红蛋白、尿微量白蛋白(UmALB)、尿α1微球蛋白(α1-MG)、尿白蛋白/肌酐比值(UACR)、Hcy、CysC水平改善更明显,差异有统计学意义(均P<0.05)。两组治疗期间均未发生不良反应。结论:益肾固摄活血通络法治疗肾虚血瘀型早期糖尿病肾病具有显著的临床疗效,能有效改善症状,降低血糖、尿蛋白、Hcy、CysC水平。
Abstract:
Objective:To observe the clinical effect of Yishen Gushe,Huoxue Tongluo method on patients with early diabetic nephropathy of kidney deficiency and blood stasis type.Methods:110 patients with early diabetic nephropathy of kidney deficiency and blood stasis type were divided into control group and observation group randomly,with 55 cases in each group.The control group was treated with basic treatment of diabetic nephropathy,and the observation group was treated with traditional Chinese medicine for Yishen Gushe,Huoxue Tongluo method on the basis of the control group.The course of treatment was two months.The changes of TCM syndrome score,glucose metabolism index,renal function index and urine protein index were compared before and after treatment in the two groups,and the overall clinical efficacy and safety of the two groups were evaluated.Results:After two months of treatment,the total effective rate rate of TCM syndrome in the observation group was 85.45%,and that in the control group was 63.64%.The total effective rate in the observation group was apparently better than that in the control group(P<0.05).After treatment,the TCM symptom score,fasting blood glucose,2 hours postprandial blood glucose,glycosylated hemoglobin,Hcy,CysC,and urinary protein related indicators of the two groups were improved to varying degrees compared with those before treatment(P<0.05).In addition,the levels of TCM symptom score,glycosylated hemoglobin,UmALB,urinary α1-MG,UACR,Hcy,CysC in the observation group were more significant improved,statistically significant(P<0.05).No adverse reactions occurred in the two groups during treatment.Conclusion:Yishen Gushe,Huoxue Tongluo method has significant clinical effect on early diabetes nephropathy of kidney deficiency and blood stasis type,which can effectively relieve the symptoms,decrease blood glucose,urinary protein,Hcy and serum CysC.

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备注/Memo

备注/Memo:
基金项目:江苏省中医药局科技项目(PY201504); 南京市医学科技发展项目(YKK15125)
更新日期/Last Update: 2023-04-10