[1]张华峰,魏 星,张 杨.健脾益气法治疗慢性萎缩性胃炎机制研究进展[J].陕西中医,2023,(6):808-810,814.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.028]
　ZHANG Huafeng,WEI Xing,ZHANG Yang.Mechanism of spleen invigorating and qi invigorating in the treatment of chronic atrophic gastritis[J].,2023,(6):808-810,814.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.028]
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健脾益气法治疗慢性萎缩性胃炎机制研究进展
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年6期
页码:
808-810,814
栏目:
综 述
出版日期:
2023-06-05

文章信息/Info

Title:
Mechanism of spleen invigorating and qi invigorating in the treatment of chronic atrophic gastritis
作者:
张华峰1; 魏 星1; 张 杨2
(1.黑龙江中医药大学,黑龙江 哈尔滨 150040; 2.黑龙江中医药大学附属第一医院,黑龙江 哈尔滨 150040)
Author(s):
ZHANG Huafeng; WEI Xing; ZHANG Yang
(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
关键词:
慢性萎缩性胃炎;  健脾;  益气;  脾胃气虚;  黏膜萎缩
Keywords:
Chronic atrophic gastritis;  Spleen invigorating;  Qi invigorating;  Spleen and stomach qi deficiency;  Atrophy of mucosa
分类号:
R 573.3
DOI:
DOI:10.3969/j.issn.1000-7369.2023.06.028
文献标志码:
A
摘要:
慢性萎缩性胃炎(CAG)是一种机制复杂、病因多样且患病率较高的胃癌前病变,健脾益气法作为治疗CAG的重要治疗大法,具有提升生活质量、加强常规药物疗效、逆转黏膜病变等优点,对于因先天禀赋不足、外邪侵袭、情志不遂、饮食失节等导致的脾胃气虚型CAG有着明显效果,在临床治疗中被广泛应用。根据现代研究发现,基于此法所用方药具备抑制炎症因子、调控基因、胃液、降低细菌感染、调节细胞增殖凋亡、影响免疫细胞等作用,因而认为健脾益气法治疗CAG作用机制可能与抗炎、修复保护胃黏膜、清除幽门螺杆菌、调控信号通路以及调节机体免疫等有关。现通过总结相关文献,对健脾益气法治疗CAG的机制进行论述。
Abstract:
Chronic atrophic gastritis(CAG)is a kind of precancerous lesion with complex mechanism,diverse etiology,and high prevalence.As an important therapeutic method for CAG,the spleen invigorating qi method is good at improving quality of life,enhancing the efficacy of conventional drugs,and reversing mucosal lesions,etc.It has obvious effect on spleen and stomach qi deficiency CAG caused by congenital deficiency of natural endowments,invasion of external evil,emotional paralysis,diet disorders and so on,and is widely used in clinical treatment.According to modern studies,the prescription used in this method can inhibit inflammatory factors,regulate genes,gastric fluid,reduce bacterial infection,regulate cell proliferation and apoptosis,and affect immune cells,etc.Therefore,the mechanism of strengthening spleen and invigorating qi in the treatment of CAG may be related to anti-inflammation,repair and protection of gastric mucosa,removal of Helicobacter pylori,regulation of signal pathway and regulation of body immunity.By summarizing relevant literature,this paper discusses the mechanism of invigorating the spleen and invigorating qi in the treatment of CAG.

参考文献/References:

[1] Yang H,Yang WJ,Hu B.Gastric epithelial histology and precancerous conditions[J].World J Gastrointest Oncol,2022,14(2):396-412.
[2] 国家消化系疾病临床医学研究中心.中国胃黏膜癌前状态及病变的处理策略专家共识(2020)[J].中华消化内镜杂志,2020,37(11):769-780.
[3] 房静远,杜奕奇,刘文忠,等.中国慢性胃炎共识意见精简版(2017年,上海)[J].上海医学,2017,40(12):705-708.
[4] 徐 晴,王 萍,姜艾利,等.从脾虚论治慢性萎缩性胃炎及胃癌前病变的思考[J].中华中医药学刊,2021,39(8):186-188.
[5] 张声生,唐旭东,黄穗平,等.慢性胃炎中医诊疗专家共识意见(2017)[J].中华中医药杂志,2017,32(7):3060-3064.
[6] 白 光,唐旭东,周红丽,等.慢性萎缩性胃炎以脾虚血瘀论治探析[J].中华中医药学刊,2021,39(9):28-31.
[7] 吉跃进,沈 洪,朱 磊.中药治疗慢性萎缩性胃炎研究进展[J].中华中医药学刊,2021,39(5):166-170.
[8] 朱方石.健脾益气方对慢性萎缩性胃炎疗效的理论机制探讨[J].中国中医基础医学杂志,2017,23(4):471-472.
[9] 吴 晋.替普瑞酮治疗老年HP阳性慢性萎缩性胃炎临床效果分析[J].陕西医学杂志,2021,50(6):735-737.
[10] 徐小颖,张北雪,逄 健,等.白术和4种不同来源的苍术对脾气虚大鼠的药效学比较[J].中国实验方剂学杂志,2020,26(15):39-45.
[11] 董 宇,赵丽沙,邱 萍,等.基于代谢组学和生物信息学的益胃饮干预胃癌前病变机制研究[J].中草药,2020,51(21):5478-5486.
[12] 刘 鹏,江晓涛,聂课朝,等.肿瘤免疫细胞因子与慢性萎缩性胃炎“炎-癌转化”研究进展[J].中华中医药杂志,2022,37(6):3346-3351.
[13] 贾 靖,徐甜甜,张 毅,等.健脾益气方治疗慢性萎缩性胃炎临床疗效[J].中国中西医结合消化杂志,2021,29(8):575-579.
[14] Tiwari SK,Shaik AS,Shaik AP,et al.Gene expression patterns of COX-1,COX-2 and iNOS in H.Pylori infected histopathological conditions[J].Microb Pathog,2019,135:103634.
[15] 聂闪闪,李 洵,赵玉航,等.加味四君子汤含药血清对胃癌细胞SGC-7901凋亡相关因子表达的影响[J].中国实验方剂学杂志,2019,25(9):25-30.
[16] 黄婷婷,周晓虹.二参三草汤治疗慢性萎缩性胃炎癌前病变的临床观察及其对PTEN、ERK、AKT表达影响的研究[J].中医药信息,2016,33(1):49-52.
[17] 王 杰,马虹宇,高云霄,等.化浊解毒方对慢性萎缩性胃炎大鼠的保护作用[J].中国中西医结合杂志,2022,42(3):348-354.
[18] 李 慧,刘金凤,奚玉杰,等.欣胃颗粒对胃癌前病变大鼠胃黏膜组织关键基因EGFR和PTEN表达的影响[J].时珍国医国药,2022,33(7):1608-1611.
[19] 裴俊文,孙太振,蒋立峰.基于对SGC-7901细胞Survivin、Bcl-2基因的调控探讨益气化瘀散结方影响胃癌细胞增殖凋亡的作用机制[J].陕西中医,2019,40(4):411-414.
[20] 张世洋,刘美辰,唐 飞,等.人参、白术有效组分群对慢性萎缩性胃炎大鼠口腔、肠道菌群的影响[J].中成药,2020,42(1):48-54.
[21] Lahner E,Carabotti M,Annibale B.Treatment of helicobacter pylori infection in atrophic gastritis[J].World Journal of Gastroenterology,2018,24(22):2373-2380.
[22] 余 明,王 博,张亚飞,等.癌前病变及胃癌与幽门螺杆菌感染的关系探讨[J].陕西医学杂志,2018,47(11):1424-1426.
[23] 时艳华,任喜尚,秦 芳,等.扶正消萎汤治疗脾胃虚弱型慢性萎缩性胃炎的临床观察[J].中华中医药学刊,2020,38(5):86-88.
[24] 王 平,赵 澄,吴 涛,等.黄芪甲苷对幽门螺杆菌定植相关因子的影响[J].中医学报,2021,36(7):1480-1485.
[25] 闫 媛,庄 坤,张 欣,等.Wnt信号通路组件在胃癌及慢性萎缩性胃炎中的表达分析[J].陕西医学杂志,2017,46(2):158-159.
[26] 刘宇旻.健脾益气方对β-catenin、GSK3β表达的影响及对CAG大鼠成模抑制作用的研究[D].南京:南京中医药大学,2017.
[27] 杜爱平,张利伟,翟亚娟.叶酸联合萎胃颗粒对HP阳性慢性萎缩性胃炎患者血清炎性指标和外周血T细胞亚群的影响[J].免疫学杂志,2019,35(2):151-156.
[28] 闫 强,杨国强.健脾清胃汤治疗脾胃虚弱型慢性萎缩性胃炎疗效及对患者免疫功能的影响[J].陕西中医,2019,40(8):1014-1017.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81973601)
更新日期/Last Update: 2023-06-09