[1]杨金月,孙宏新,施艾每,等.基于数据挖掘分析孙宏新治疗肺癌用药规律[J].陕西中医,2024,(9):1278-1282.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.030]
　YANG Jinyue,SUN Hongxin,SHI Aimei,et al.Discussion on SUN Hongxin's medication rule of traditional Chinese medicine in treating lung cancer based on data mining[J].,2024,(9):1278-1282.[doi:DOI:10.3969/j.issn.1000-7369.2024.09.030]
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基于数据挖掘分析孙宏新治疗肺癌用药规律
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2024年9期
页码:
1278-1282
栏目:
方药纵横
出版日期:
2024-09-05

文章信息/Info

Title:
Discussion on SUN Hongxin's medication rule of traditional Chinese medicine in treating lung cancer based on data mining
作者:
杨金月1; 孙宏新2; 施艾每1; 贾金虎1
(1.河南中医药大学,河南 郑州 450000; 2.河南中医药大学第一附属医院,河南 郑州 450000)
Author(s):
YANG Jinyue; SUN Hongxin; SHI Aimei; JIA Jinhu
(Henan University of Chinese Medicine,Zhengzhou 450000,China)
关键词:
肺癌;  中医药治疗;  孙宏新;  用药规律;  经验方;  数据挖掘
Keywords:
Lung cancer;  Traditional Chinese medicine treatment;  SUN Hongxin;  Regularity of medication;  Empirical prescription;  Data mining
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7369.2024.09.030
文献标志码:
A
摘要:
目的:收集孙宏新主任医师门诊使用中药治疗肺癌相关病例,采用数据挖掘技术,探讨其临床使用中医药治疗肺癌的用药规律,为临床治疗肺癌提供借鉴。方法:收集、整理孙宏新主任医师使用中医药治疗肺癌的门诊病例,建立肺癌病案数据库,对处方数据中所使用的中药进行频数统计、药物关联分析、聚类分析、因子分析。结果:此次纳入病案369例、总计1009诊次,涉及374味中药(累计频次19080次),分析得到仙鹤草、甘草、紫苏梗、半夏、蜀羊泉、合欢皮等20个高频中药,聚类识别为经典方“六君子汤、逍遥散”和孙宏新主任医师自拟经验方“二金合欢皮汤”; 中药性味归经分析:四气以温、平、寒为主,五味以甘、苦、辛为主,归经以肺、脾、肝经为主; 对高频中药进行相关性分析:药物-药物关联分析得到4个核心药组; 聚类分析得到4类药物组方; 因子分析提出3个公因子。结论:孙宏新主任医师治疗肺癌以补虚扶正、抗癌解毒为主; 从肺、脾、肝入手,辅以理气止咳化痰、并健脾补肺疏肝,意在培土生金、兼疏肝郁,寓攻于补,攻补兼施。可见孙宏新主任医师治疗肺癌秉持维持机体内“平衡”,在抗癌的同时,重视缓解患者痛苦,保存患者体力,延长生存期的学术特点。
Abstract:
Objective:Collect the case records of Dr.SUN Hongxin a chief physician,who uses Chinese herbal medicine to treat lung cancer,and apply data mining techniques to explore the drug usage patterns in her clinical use of Chinese medicine for lung cancer treatment.This can provide reference for clinical treatment of lung cancer.Methods:Chief physician SUN Hongxin's outpatient cases of lung cancer treated by TCM were collected and sorted out.The database of liver cancer cases was established,and the data were analyzed by frequency statistics,drug association analysis,cluster analysis and factor analysis.Results:369 cases of medical records were included in this study,totaling 1009 visits,involving 374 flavors of TCM(cumulative frequency of 19080 times),20 high-frequency Chinese medicines were screened out by frequency statistical analysis,such as Xianhecao,Gancao,Perilla stem,Banxia,Shuyangquan and Huanpi,were identified as the classic prescription “Liujunzi decoction,Xiaoyao decoction” and “Erjinhehuanpi decoction” designed by chief physician SUN Hongxin.Statistical analysis of TCM properties and meridians:The medicinal four qi were mainly warm,flat or cold,five wei were mainly sweet,bitter or pungent,the herb meridians were mainly lung meridian,spleen meridian or liver meridian.Correlation analysis of high-frequency Chinese medicine:4 core medicine groups are obtained by association rule analysis.4 drug combinations are obtained by cluster analysis.Factor analysis presents 3 common factors.Conclusion:Chief physician SUN Hongxin's traditional Chinese medicine treatment of lung cancer is focus on given priority to with tonifying deficiency,strengthening vital qi and anti-cancer.Starting from lung,spleen and liver,assisted clearing heat and phlegm,regulating qi and relieving cough.And aiming at cultivating soil and producing gold,and sparse liver depression.Combining attack with tonifying and replenishing.It can be seen that chief physician SUN Hongxin adheres to the idea of achieving “balance” in the body in the treatment of lung cancer,relieving patients pain,preserving patients physical strength and prolonging their survival while fighting cancer.

参考文献/References:

[1] 国家药典委员会.中华人民共和国药典:一部[M].北京:中国医药科技出版社,2020:1878-1881.
[2] 李灿东.中医诊断学[M].北京:中国中医药出版社,2018:231-233.
[3] 贾英杰.中西医结合肿瘤学[M].武汉:华中科技大学出版社,2009:723-754.
[4] 黄甫浩静,薄荣强,李萍.基于真实世界的名老中医辨治肺癌的复杂网络分析[J].中医药导报,2023,29(8):157-162.
[5] 刘珍,刘馨怡,金禹辰.基于数据挖掘探析现代湖湘名中医治疗肺癌用药规律[J].湖南中医杂志,2023,39(7):41-47.
[6] 孙宏新,孙君.周宜强教授诊治肺癌经验[J].中国中医药信息杂志,2000,7(4):68-69.
[7] 刘福栋,姜晓晨,花宝金.全国名中医朴炳奎“扶正培本”防治肺癌经验探析[J].北京中医药,2022,41(5):490-493.
[8] 张曦文,朴炳奎,花宝金.基于信息挖掘技术分析朴炳奎教授肺癌对症治疗用药与处方规律[J].世界中西医结合杂志,2020,15(6):1002-1008.
[9] 段启,孙宏新,袁成凤.孙宏新治疗肺癌合并肺部感染经验[J].中医临床研究,2021,13(35):39-41.
[10] 胡哲君,汤穆浛,张锐,等.基于“肝病实脾”理论探讨逍遥散对肝纤维化大鼠肝星状细胞铁死亡的影响[J].陕西中医, 2024,45(2):159-164.
[11] 董鑫,申俊丽,孙宏新.孙宏新治疗恶性肿瘤思想初探[J].中国民间疗法,2019,11(10):14-15.
[12] 罗阳敏,孙维旭,王银菊,等.六君子汤联合西药治疗慢性肺炎疗效及对患者肺功能的影响[J].陕西中医.2018,39(11):1540-1543.
[13] 梁玉,李艳芳,王小波.逍遥散联合重复经颅磁刺激治疗肝郁脾虚型抑郁症疗效及对患者血清FGF-22、BDNF水平的影响[J].陕西中医,2021,42(1):33-36.
[14] 钟赣生.中药学[M].北京:中国中医药出版社,2012:479-482.
[15] 李中梓.医宗必读[M].北京:人民卫生出版社出版,2006:404-464.
[16] 彭丽蓉,彭海燕.仙鹤草抗癌作用的临床与实验研究进展[J].中华中医药杂志,2022,37(7):3992-3994.
[17] 张尚龙,闫潇,杨秀娟,等.基于网络药理学和细胞验证探讨甘草抗肺癌机制[J].中国中医药信息杂志,2023,30(10):36-40.
[18] 刘裕良.中药龙葵、白英的甾体生物碱类成分及抗肿瘤作用研究[D].北京:中国中医科学院,2022.
[19] 崔迎霞.孙宏新主任医师应用半夏治疗恶性肿瘤经验[D].郑州:河南中医药大学,2019.
[20] 王恒,于淼,李伟楠.半夏化学成分及抗肿瘤作用机制研究进展[J].中医药导报,2021,27(8):49-52.
[21] 银瑞,王俊钢.白术多糖对肺癌模型大鼠免疫功能的调节作用及机制研究[J].中国医药生物技术,2019,14(6):527-533.
[22] TSUNEKI H,MA E,KOBAYASHI S,et al.Antiangiogenic activity of β-eudesmol in vitro and in vivo [J].European Journal of Pharmacology,2005,512(2):105-115.
[23] 杨金伟,张莹.猫爪草提取部位及有效成分抗肿瘤作用的研究进展[J].药物评价研究,2021,44(2):446-451.
[24] 于弘,胡倩,周光飚.肺癌中医证型与用药规律的研究[J].中成药,2022,44(7):2273-2278.
[25] 孙民朋,孙宏新.“大毒治病,十去其六”在肿瘤临床应用浅析[J].中医肿瘤学杂志,2022,4(3):1-4.
[26] 王树堂,周岱翰.从恶性肿瘤疗效评价的再认识谈完善中医肿瘤疗效评价标准的紧迫性[J].中医肿瘤学杂志,2023,5(3):1-7.

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备注/Memo

备注/Memo:
基金项目:河南省中医药科学研究专项课题(2019JDZX029)
更新日期/Last Update: 2024-09-09