[1]张 娜,黄玉珍,苏坤涵,等.参莲消积方治疗慢性萎缩性胃炎气虚瘀热证临床研究[J].陕西中医,2025,46(2):197-200.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.010]
 ZHANG Na,HUANG Yuzhen,SU Kunhan,et al.Clinical observation of Shenlian Xiaoji decoction in treating chronic atrophic gastritis with Qi deficiency and stasis-heat syndrome[J].,2025,46(2):197-200.[doi:DOI:10.3969/j.issn.1000-7369.2025.02.010]
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参莲消积方治疗慢性萎缩性胃炎气虚瘀热证临床研究
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年2期
页码:
197-200
栏目:
临床研究
出版日期:
2025-02-05

文章信息/Info

Title:
Clinical observation of Shenlian Xiaoji decoction in treating chronic atrophic gastritis with Qi deficiency and stasis-heat syndrome
作者:
张 娜1黄玉珍2苏坤涵1刘万里2
(1.南京中医药大学附属南京市中西医结合医院,江苏 南京 210014; 2.南京医科大学附属南京医院消化科,江苏 南京 210006)
Author(s):
ZHANG Na1HUANG Yuzhen2SU Kunhan1LIU Wanli2
(1.Nanjing Hospital of Integrated Chinese and Western Medicine Affiliated to the Nanjing University of Chinese Medicine,Nanjing 210014,China; 2.Department of Gastroenterology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)
关键词:
慢性萎缩性胃炎 气虚瘀热证 参莲消积方 胃蛋白酶原 γ干扰素
Keywords:
Chronic atrophic gastritis Qi deficiency and stasis-heat syndrome Shenlian Xiaoji decoction Pepsinogen Interferon-γ
分类号:
R 573.3
DOI:
DOI:10.3969/j.issn.1000-7369.2025.02.010
文献标志码:
A
摘要:
目的:分析参莲消积方治疗慢性萎缩性胃炎(CAG)气虚瘀热证的治疗效果。方法:采用随机数字表法将60例CAG气虚瘀热证患者分为观察组和对照组各30例,分别给予参莲消积方、胃复春片口服治疗,疗程皆为24周。对比分析两组治疗效果、两组前后中医证候积分、胃蛋白酶原Ⅰ(PG Ⅰ)、胃蛋白酶原Ⅱ(PG Ⅱ)、γ-干扰素(IFN-γ)水平的变化情况,并记录不良反应。结果:观察组治疗总有效率为86.67%(26/30),显著高于对照组的63.33%(19/30,P<0.05),两组治疗后中医证候积分均显著低于治疗前(P<0.05),PGⅠ、PGⅡ、IFN-γ水平均显著改善(P<0.05),观察组治疗后各项指标改善情况均优于对照组(P<0.05),两组均未见不良反应。结论:参莲消积方治疗CAG气虚瘀热证的临床疗效显著,可有效缓解症状,改善PGⅠ、PGⅡ、IFN-γ水平。
Abstract:
Objective:To evaluate the efficacy of Shenlian Xiaoji decoction in the management of chronic atrophic gastritis with Qi deficiency and stasis-heat syndrome.Methods:The investigation involved 60 participants,suffering from this condition,who were randomly allocated to either the observation group(comprising 30 cases)or the control group(also consisting of 30 cases).The duration of the therapeutic intervention was fixed at 24 weeks.The control group was treated with Weifuchun tablet,and the observation group was treated with Shenlian Xiaoji decoction.The therapeutic efficacy,TCM syndrome scores,PGⅠ,PGⅡ,and IFN-γ levels were compared and analyzed between the two groups before and after treatment.Additionally,any adverse reactions were meticulously documented.Results:The overall effective rate in the observation group was 86.67%(26/30),which was significantly superior to that of the control group 63.33%(19/30,P<0.05).Furthermore,the TCM syndrome scores in both groups after treatment were substantially lower compared to those prior to treatment(P<0.05).The levels of PGⅠ,PGⅡ and IFN-γ were significantly improved(P<0.05),and additionally,the post-treatment improvement in all indices within the observation group was superior to those observed in the control group,with statistical significance(P<0.05).There were no adverse reactions in both groups.Conclusion:Shenlian Xiaoji decoction has significant clinical efficacy in the treatment of chronic atrophic gastritis with Qi deficiency and stasis-heat syndrome,which can effectively relieve symptoms and improve PGⅠ,PGⅡ and IFN-γ levels.

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备注/Memo

备注/Memo:
[基金项目]国家自然科学基金资助项目(82174125); 江苏省中医药领军人才培养项目[苏中医科教(2023)17号]; 南京市卫生科技发展专项资金资助项目(YKK21193)
更新日期/Last Update: 2025-02-08