[1]孙雪琴,黄雷,刘尚.通督调神针法治疗急性脑梗死疗效及对患者kruppel样转录因子2、内皮型一氧化氮合酶3的影响[J].陕西中医,2025,46(6):835-838,843.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.024]
　SUN Xueqin,HUANG Lei.Tongdu Tiaoshen acupuncture on acute cerebral infarction and its influence on KLF2 and NOS3[J].,2025,46(6):835-838,843.[doi:DOI:10.3969/j.issn.1000-7369.2025.06.024]
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通督调神针法治疗急性脑梗死疗效及对患者kruppel样转录因子2、内皮型一氧化氮合酶3的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年6期
页码:
835-838,843
栏目:
针灸经络
出版日期:
2025-06-05

文章信息/Info

Title:
Tongdu Tiaoshen acupuncture on acute cerebral infarction and its influence on KLF2 and NOS3
作者:
孙雪琴; 黄雷; 刘尚
（湖南中医药大学第一附属医院疼痛科，湖南 长沙 410021）
Author(s):
SUN Xueqin; HUANG Lei
（Pain Department of the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410021,China）
关键词:
急性脑梗死; 针刺; 通督调神; kruppel样转录因子2; 内皮型一氧化氮合酶3; 血管内皮功能
Keywords:
Acute cerebral infarction; Acupuncture; Tongdu Tiaoshen; Kruppel-like transcription factor 2; Endothelial nitric oxide synthase 3; Vascular endothelial function
分类号:
R 743.3
DOI:
DOI:10.3969/j.issn.1000-7369.2025.06.024
文献标志码:
A
摘要:
目的：探讨通督调神针法治疗急性脑梗死（ACI）的临床疗效，初步分析其作用机制。方法：将ACI患者114例随机分为观察组和对照组，每组57例，观察组予以通督调神针刺，对照组予以常规针刺，疗程为4周。比较两组症状评分、美国国立卫生研究院卒中量表（NIHSS）评分、Fugl-Meyer 量表（FMA）评分、改良Berthel指数量表（MBI）评分，并比较两组血清kruppel样转录因子2（KLF2）、内皮型一氧化氮合酶3（NOS3）、血管内皮生长因子（VEGF）、内皮素-1（ET-1）、一氧化氮（NO）水平，并比较两组治疗总有效率。结果：治疗后观察组主要症状半身不遂、口角歪斜、言语不利、舌强言謇低于对照组（P＜0.01），NIHSS评分低于对照组（P＜0.01），FMA评分、MBI评分高于对照组（P＜0.01），血清KLF2、NOS3高于对照组（P＜0.01），血清VEGF、ET-1、NO水平低于对照组（P＜0.01），治疗总有效率高于对照组（P＜0.05）。结论：通督调神针法可有效缓解患者症状，提高日常生活活动能力，治疗ACI效果显著，其机制可能与调节KLF2、NOS3表达，改善血管内皮功能有关。
Abstract:
Objective:To explore the clinical efficacy of the Tongdu Tiaoshen acupuncture in the treatment of acute cerebral infarction (ACI),and to analyze its mechanism of action preliminarily.Methods:A total of 114 ACI patients were divided into an observation group and a control group,with 57 cases in each group.The observation group were treated with Tongdu Tiaoshen acupuncture,while the control group were treated with routine acupuncture for a course of 4 weeks.The symptom scores,National Institutes of Health Stroke Scale (NIHSS) scores,Fugl Meyer Scale (FMA) scores,and Modified Berthel Index (MBI) scores before and after treatment between two groups were compared,and the serum levels of kruppel-like transcription factor 2 (KLF2),endothelial nitric oxide synthase 3 (NOS3),vascular endothelial growth factor (VEGF),endothelin-1 (ET-1),and nitric oxide (NO) between the two groups were compared, the total effective rate of the two groups was compared.Results:The main symptoms of the observation group were hemiplegia,crooked corners of the mouth,poor speech,and strong tongue of the observation group were lower than those of the control group (P<0.01).The NIHSS score was lower than that of the control group (P<0.01),FMA score and MBI score were higher than those of the control group (P<0.01),serum KLF2 and NOS3 were higher than those of the control group (P<0.01),serum VEGF,ET-1,and NO levels were lower than those of the control group (P<0.01),and the total effective rate of treatment was higher than that of the control group (P<0.05).Conclusion:Tongdu Tiaoshen acupuncture can effectively alleviate symptoms,improve daily living activities,and it has a significant therapeutic effect on ACI.Its mechanism may be related to regulating the expression of KLF2 and NOS3,and improving vascular endothelial function.

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备注/Memo

备注/Memo:
湖南省自然科学基金资助项目(2024JJ9439)
更新日期/Last Update: 2025-06-09