[1]邹玲孜,朱莹.基于“土壅木郁”探讨慢性萎缩性胃炎合并焦虑状态的论治[J].陕西中医,2025,46(10):1371-1375.[doi:DOI:10.3969/j.issn.1000-7369.2025.10.014]
 ZOU Lingzi,ZHU Ying.Discussion on the treatment of chronic atrophic gastritis complicated with anxiety state based on the theory of “earth stagnation and wood depression”[J].,2025,46(10):1371-1375.[doi:DOI:10.3969/j.issn.1000-7369.2025.10.014]
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基于“土壅木郁”探讨慢性萎缩性胃炎合并焦虑状态的论治

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年10期
页码:
1371-1375
栏目:
学术探讨
出版日期:
2025-10-05

文章信息/Info

Title:
Discussion on the treatment of chronic atrophic gastritis complicated with anxiety state based on the theory of “earth stagnation and wood depression”
作者:
邹玲孜朱莹
(湖南中医药大学第一附属医院,湖南 长沙 410007)
Author(s):
ZOU LingziZHU Ying
(The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
关键词:
慢性萎缩性胃炎土壅木郁焦虑抑郁病因病机
Keywords:
Chronic atrophic gastritisEarth stagnationWood depressionAnxiety stateDepressive stateEtiology and pathogenesis
分类号:
R 573.32
DOI:
DOI:10.3969/j.issn.1000-7369.2025.10.014
文献标志码:
A
摘要:
慢性萎缩性胃炎(CAG)是临床上常见的一种慢性胃部疾病,主要表现为反复发作且无规律上腹部疼痛不适或者胀满疼痛等。对于CAG,西医缺乏明显有效的治疗手段,而中医从整体观念论治,对于CAG的治疗具有明显的优势。通过阐述“土壅木郁”的理论内涵,从而探讨慢性萎缩性胃炎合并焦虑状态的发病机制,认为“脾虚土壅”是CAG合并焦虑状态的发病之本,而“木郁不畅”是CAG合并焦虑状态发病的关键之因。而HP感染、炎症免疫反应异常、脑肠轴功能失调在一定程度上反映了“土壅木郁”的状态,影响了CAG 合并焦虑状态的发生发展。治疗当以健运脾气贯穿治病的整个过程,配合疏肝通络治法,CAG病情迁延不愈,病程较长,久病必瘀,治病后期当以配合祛瘀通络之法,佐以心理疏导,调畅情志。
Abstract:
Chronic atrophic gastritis (CAG) is a common chronic gastric disease in clinical practice,mainly characterized by recurrent and irregular upper abdominal pain,discomfort or distension and pain.Western medicine lacks effective therapy for CAG,while traditional Chinese medicine has obvious advantages based on the holistic concept.By elaborating on the the theoretical connotation of “earth stagnation and wood depression”,this article explores the pathogenesis of CAG combined with anxiety state,and holds that “spleen deficiency and earth congestion” is the root cause of CAG combined with anxiety state,while “wood depression and lack of smoothness” is the key factor.Helicobacter pylori (HP) infection,abnormal inflammatory immune response,and brain-gut axis dysfunction to some extent reflect the state of “earth stagnation and wood depression”,which affects the occurrence and development of CAG combined with anxiety state.The treatment should focus on invigorating and regulating the spleen qi throughout the entire treatment process,combined with the method of soothing the liver and unblocking the meridians.As CAG has a prolonged course and is difficult to cure,long-term illness leads to blood stasis.In the later stage of treatment,it is necessary to combine the method of removing blood stasis and unblocking the meridians,and assist with psychological counseling to regulate emotions.

参考文献/References:

[1]张声生,刘吉祥,李丹艳,等.慢性萎缩性胃炎及胃癌前病变的中医诊疗前景广阔[J].中国中西医结合消化杂志,2024,32(6):461-468.
[2]YIN Y,LIANG H,WEI N,et al.Prevalence of chronic atrophic gastritis worldwide from 2010 to 2020:An updated systematic review and meta-analysis[J].Ann Palliat Med,2022,11(12):3697-3703.
[3]LI J,PAN J,XIAO D,et al.Chronic atrophic gastritis and risk of incident upper gastrointestinal cancers:A systematic review and meta-analysis[J].J Transl Med,2024,22(1):429.
[4]苏春娇,吴媛媛.焦虑抑郁对慢性非萎缩性胃炎消化道症状的影响[J].国际精神病学杂志,2024,51(6):1931-1933.
[5]朱延涛,王国军.慢性萎缩性胃炎的中医药治疗研究进展[J].浙江临床医学,2025,27(2):312-313.
[6]黄元御,张琦.四圣心源[M].北京:中国医药科技出版社,2020:121-122.
[7]孙宁宁,叶永安.“土壅木郁”理论及其在肝病临床中的应用[J].世界中医药,2015,10(3):383-386.
[8]唐容川,吴少祯.血证论[M].北京:中国医药科技出版社,2020:88.
[9]秦伯未.增补谦斋医学讲稿[M].北京:中国医药科学技术出版社,2021:232-233.
[10]刘頔,纪立金.浅谈“土壅木郁”理论与临床运用[J].中华中医药杂志,2021,36(4):1956-1958.
[11]刘玲,陆西宛,何珂,等.七味白术散对脾虚湿困型肥胖症患者糖脂代谢及肠道菌群的影响[J].中医杂志,2020,61(23):2082-2086.
[12]李莉,朱蕾蕾,孙祝美,等.慢性萎缩性胃炎中医证型分布及幽门螺杆菌感染、胃黏膜病理变化情况分析[J].上海中医药杂志,2019,53(6):20-23.
[13]陈柳伊,弓明燕,陈泽林.对肠-脑-皮轴及其与中医联系的思考[J].中华中医药杂志,2019,34(1):275-277.
[14]徐楚楚.慢性萎缩性胃炎患者睡眠质量与中医证型及病理分型的相关性研究[D].北京:北京中医药大学,2021.
[15]李军祥,陈誩,吕宾,等.慢性萎缩性胃炎中西医结合诊疗共识意见(2017年)[J].中国中西医结合消化杂志,2018,26(2):121-131.
[16]吉祥,卞兆连,邵建国.幽门螺杆菌与胃癌的研究进展[J].交通医学,2021,35(2):129-134.
[17]伍抒妍.慢性胃炎患者幽门螺杆菌阳性与焦虑抑郁情绪严重程度及消化道症状的相关性分析[J].大医生,2024,9(13):106-109.
[18]吴国江,万爱兰,杨肇熙,等.神经质人格对HP感染人群生存质量的影响:焦虑抑郁的中介作用[J].南昌大学学报(医学版),2020,60(1):79-82.
[19]WESSLER S,KRISCH L M,ELMER D P,et al.From inflammation to gastric cancer:The importance of hedgehog/gli signaling in helicobacter pylori-induced chronic inflammatory and neoplastic diseases[J].Cell Commun Signal,2017,15(1):15.
[20]SONG H,HELD M,SANDIN S,et al.Increase in the prevalence of atrophic gastritis among adults age 35 to 44 years old in northern sweden between 1990 and 2009[J].Clin Gastroenterol Hepatol,2015,13(9):1592-1600.
[21]黎秀娟,黎丽群,马超北,等.基于“脾-线粒体相关”探讨NLRP3炎症小体与慢性萎缩性胃炎的关系[J].中国实验方剂学杂志,2023,29(17):267-273.
[22]李金萍,刘阳,李桂云.基于胃黏膜MyD88、ATF2、NF-κB蛋白表达情况分析化浊解毒方加减治疗慢性萎缩性胃炎的机制[J].四川中医,2024,42(9):123-127.
[23]林秩冰,张丹,李长政,等.情绪障碍在炎症性肠病发病机制中的研究进展[J].国际精神病学杂志,2024,51(6):1703-1706.
[24]CAO Y,CHEN H,TAN Y,et al.Protection of p-coumaric acid against chronic stress-induced neurobehavioral deficits in mice via activating the pka-creb-bdnf pathway[J].Physiol Behav,2024,273:114415.
[25]刘磊,李冰冰,林家茂.“慢性应激-免疫微环境重塑”视角下的乳腺癌肝郁证治解读[J].疑难病杂志,2023,22(9):999-1003.
[26]MAYER E A,NANCE K,CHEN S.The gut-brain axis[J].Annu Rev Med,2022,73:439-453.
[27]TAIT C,SAYUK G S.The brain-gut-microbiotal axis:A framework for understanding functional GI illness and their therapeutic interventions[J].Eur J Intern Med,2021,84:1-9.
[28]倪兴国.慢性萎缩性胃炎伴肠上皮化生的相关因素研究[D].哈尔滨:黑龙江中医药大学,2023.
[29]李元.基于脑肠肽探讨功能性腹泻脾虚证“脾失健运”生物学机制及中药疗效机制[D].北京:北京中医药大学,2018.
[30]王伟明,柳昕坤,施嘉祥,等.基于脑—肠轴理论从肝论治消化性溃疡的中医治要探析[J].环球中医药,2025,18(4):764-768.
[31]廖小梅.抑郁症与甲状腺激素的研究进展[J].中国实用神经疾病杂志,2024,27(10):1316-1320.

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备注/Memo

备注/Memo:
国家自然科学基金资助项目(82374426);全国名老中医药专家传承工作室建设项目[国中医药人教函(2022)75号]
更新日期/Last Update: 2025-10-10