[1]陈澍,邓媛媛,张勉之.基于“血不利则为水”理论探讨巨噬细胞极化与糖尿病肾病相关性[J].陕西中医,2026,(4):522-525,530.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.017]
　CHEN Shu,DENG Yuanyuan,ZHANG Mianzhi.The correlation between macrophage polarization and diabetic nephropathy based on the TCM theory of “unsmooth blood circulation results in water”[J].,2026,(4):522-525,530.[doi:DOI:10.3969/j.issn.1000-7369.2026.04.017]
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基于“血不利则为水”理论探讨巨噬细胞极化与糖尿病肾病相关性

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2026年4期
页码:
522-525,530
栏目:
学术探讨
出版日期:
2026-04-05

文章信息/Info

Title:
The correlation between macrophage polarization and diabetic nephropathy based on the TCM theory of “unsmooth blood circulation results in water”
作者:
陈澍1; 邓媛媛1; 张勉之2; 3; 4
（1.北京中医药大学，北京 100029；2.北京中医药大学附属东方医院，北京 100078；3.天津市中医药研究院附属医院，天津 300120；4.天津市中西医结合医院,天津 300100)
Author(s):
CHEN Shu1; DENG Yuanyuan1; ZHANG Mianzhi2; 3; 4
（1.Beijing University of Chinese Medicine,Beijing 100029，China；2.Oriental Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100078，China；3.Tianjin Research Institute of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China；4.Tianjin Traditional Chinese and Western Medicine Hospital,Tianjin 300100,China)
关键词:
糖尿病肾病; 巨噬细胞; 血不利则为水; 肾络瘀滞; 水湿内停; 补肾活血
Keywords:
Diabetic nephropathy; Macrophage; Unsmooth blood circulation results in water; Renal collaterals stasis; Internal retention of water-dampness; Tonify the kidney and activate blood circulation
分类号:
R 587.2
DOI:
DOI:10.3969/j.issn.1000-7369.2026.04.017
文献标志码:
A
摘要:
糖尿病肾病（DN）是糖尿病的高发并发症之一，其病程迁延难愈。肾脏M1/M2型巨噬细胞极化失衡与肾脏免疫紊乱、肾组织炎症与纤维化密切相关；“血不利则为水”是中医阐释血水代谢的经典理论，揭示血瘀与水停的病理关联，而巨噬细胞的极化过程与该理论高度契合。基于此探讨“血不利则为水”、巨噬细胞极化与DN的关系，认为“肾络瘀滞”为其病因之本，“水湿内停”为其病因之标。“肾络瘀滞”核心源于脾肾气阴亏虚，“水湿内停”主要是瘀、湿、浊毒留滞，治法以补肾活血、健脾利湿、化浊解毒、养阴清热为主，以达血水调和，为DN的诊治提供思路。
Abstract:
Diabetic nephropathy (DN) is one of the highly prevalent complications of diabetes mellitus,characterized by a protracted and refractory clinical course.The imbalance of M1/M2 macrophage polarization in the kidney is closely associated with renal immune disorder,renal tissue inflammation and fibrosis.The theory of “unsmooth blood circulation results in water” is a classic traditional Chinese Medicine doctrine illustrating the metabolism of blood and body fluid,revealing the pathological correlation between blood stasis and fluid accumulation.Notably,the process of macrophage polarization is highly consistent with this theory.Based on this,we explore the relationship among “unsmooth blood circulation results in water”,macrophage polarization and DN,proposing that “renal collaterals stasis” serves as the fundamental etiology,while “internal retention of water-dampness” acts as the superficial manifestation.The core mechanism of “renal collaterals stasis” originates from Qi-Yin deficiency of the spleen and kidney,and “internal retention of water-dampness” is mainly caused by the stagnation of blood stasis,dampness and turbid toxin.The therapeutic principles include tonifying the kidney and activating blood circulation,invigorating the spleen and resolving dampness,eliminating turbidity and detoxifying,as well as nourishing Yin and clearing heat,so as to achieve the harmony of blood and fluid,thereby providing novel insights for the diagnosis and treatment of DN.

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备注/Memo

备注/Memo:
国家自然科学基金资助面上项目（82074242）；中央高水平中医医院临床科研业务费资助项目（DFRCZY-2024ARC-003）；张勉之天津市名中医传承工作室建设项目
更新日期/Last Update: 2026-04-05