[1]胡兴律,王向阳,唐远山,等.定眩饮治疗后循环缺血性眩晕随机对照研究[J].陕西中医杂志,2021,(10):1375-1378.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.012]
　HU Xinglyu,WANG Xiangyang,TANG Yuanshan,et al.A randomized controlled study of Dingxuan decotiom in the treatment of circulatory ischemic vertigo[J].,2021,(10):1375-1378.[doi:DOI:10.3969/j.issn.1000-7369.2020.10.012]
点击复制

定眩饮治疗后循环缺血性眩晕随机对照研究
分享到：

《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2021年10期
页码:
1375-1378
栏目:
临床研究
出版日期:
2021-10-05

文章信息/Info

Title:
A randomized controlled study of Dingxuan decotiom in the treatment of circulatory ischemic vertigo
作者:
胡兴律1; 王向阳1; 唐远山1; 李 霖1; 2; 殷继超 2; 刘 波1; 段青于蓝1
(1.西安市中医医院,陕西 西安 710021; 2.陕西中医药大学,陕西 咸阳 712046)
Author(s):
HU Xinglyu; WANG Xiangyang; TANG Yuanshan; LI Lin; YIN Jichao; LIU Bo; DUAN Qingyulan
(Xi'an Traditional Chinese Medicine Hospital,Xi'an 710021,China)
关键词:
后循环缺血;  眩晕;  定眩饮;  经颅多普勒超声;  眩晕障碍量表;  血流平均速度;  双侧椎动脉
Keywords:
Posterior circulation ischemia;  Vertigo;  Dingxuan decotiom;  Transcranial doppler ultrasound;  Mean blood flow velocity;  Bilateral vertebral artery
分类号:
R 255.3
DOI:
DOI:10.3969/j.issn.1000-7369.2020.10.012
文献标志码:
A
摘要:
目的:探讨定眩饮对后循环缺血性眩晕患者临床症状、生活质量的改善情况,观察治疗前后经颅多普勒超声参数的变化。方法:将70例后循环缺血性眩晕患者随机分为治疗组和对照组,每组35例。对照组给予口服尼莫地平片(30 mg,3次/d,连续治疗2周为1个疗程)。治疗组予以口服定眩饮治疗(每日1剂,早晚口服200 ml,连续服用2周为1个疗程)。2个疗程后比较两组患者眩晕障碍量表(DHI)评分和中医临床证候积分的变化情况,同时观察两组患者治疗前、治疗2周后、治疗4周后的双侧椎动脉(BVA)和基底动脉(BA)的血流平均速度(Vm)的变化。 结果:治疗组的总有效率显著高于对照组(P<0.05); 治疗组患者眩晕障碍量表(DHI)评分和中医临床证候积分的改善情况明显优于对照组,差异有统计学意义(P<0.05); 治疗组在治疗2周后、治疗4周后的椎-基底动脉平均血流速度(Vm)明显高于对照组(P<0.05)。 结论:定眩饮能够有效缓解患者的眩晕症状,同时能够调节和改善患者椎-基底动脉的平均血流速度,是治疗后循环缺血性眩晕的一种有效的方法。
Abstract:
Objective:To investigate the improvement of clinical symptoms and quality of life in patients with posterior circulation ischemic vertigo treated with oral Dingxuan decotiom,and to observe the changes of transcranial doppler ultrasound parameters before and after treatment.Methods:70 patients with posterior circulation ischemic vertigo were randomly divided into treatment group(n=35)and control group(n=35).The control group was given nimodipine orally(30 mg,3 times a day,continuous treatment for 2 weeks as a course of treatment).The treatment group was treated with oral Dingxuan decotiom(one dose a day,200 ml in the morning and evening for 2 weeks as a course of treatment).After two courses of treatment,the changes of Dizziness handicap inventory(DHI)score of vertigo disorder scale and TCM clinical syndrome score were compared between the two groups.At the same time,the changes of mean blood flow velocity(Vm)of bilateral vertebral artery(BVA)and basilar artery(BA)were observed before treatment,after treatment and 2 weeks after treatment.Results:The effective rate of the treatment group was significantly higher than that of the control group,the DHI score of vertigo disorder scale and the score of TCM clinical syndrome in the treatment group were significantly better than those in the control group,and the average blood flow velocity of vertebrobasilar artery Vm in the treatment group was significantly higher than that in the control group after treatment and 2 weeks after treatment.Conclusion:Dingxuan decotiom can effectively relieve the symptoms of vertigo and regulate and improve the average blood flow velocity of vertebrobasilar artery.Dingxuan decotiom is an effective method for the treatment of posterior circulation ischemic vertigo.

参考文献/References:

[1] Cao Z,Zhu C,Zhou Y,et al.Risk factors related balance disorder for patients with dizziness/vertigo[J].BMC Neurol,2021,21(1):186.
[2] 黄 泽,胡跃强,陈莲梅,等.血府逐瘀汤治疗眩晕病研究进展[J].陕西中医,2020,41(8):1169-1172.
[3] Amin-Hanjani S,Stapleton CJ,Du X,et al.Hypoperfusion symptoms poorly predict hemodynamic compromise and stroke risk in vertebrobasilar disease[J].Stroke,2019,50(2):495-497.
[4] Merwick A,Werring D.Posterior circulation ischaemic stroke[J].BMJ,2014,348:3175.
[5] Gulli G,Khan S,Markus HS.Vertebrobasilar stenosis predicts high early recurrent stroke risk in posterior circulation stroke and TIA[J].Stroke,2009,40(8):2732-2737.
[6] Herdman D,Norton S,Pavlou M,et al.Vestibular deficits and psychological factors correlating to dizziness handicap and symptom severity[J].J Psychosom Res,2020,132:109969.
[7] 丛 宇,韩 旭,张忠平,等.针刺联合半夏白术天麻汤治疗痰浊中阻型颈性眩晕34例临床观察[J].中国民族民间医药,2018,27(8):80-82.
[8] 周卉芳.前列地尔注射液治疗后循环缺血的疗效及血流动力学分析[J].医药论坛杂志,2018,39(8):146-147.
[9] 刘天琪.天麻素注射液联合长春西汀注射液治疗急性眩晕的临床观察[J].中西医结合心脑血管病杂志,2018,16(8):1137-1138.
[10] 蔡 洪,杨德钱.半夏白术天麻汤对后循环缺血性眩晕的临床研究[J].中国中医急症,2019,28(5):848-850.
[11] Tsai TY,Li CY,Livneh H,et al.Decreased risk of stroke in patients receiving traditional Chinese medicine for vertigo:A population-based cohort study[J].J Ethnopharmacol,2016,184:138-143.
[12] Ma H,Guo L,Chen Y,et al.Linggui Zhugan decotiom for peripheral vertigo:A protocol for systematic review and meta-analysis[J].Medicine(Baltimore),2021,100(16):e25563.
[13] 宋旭丹,张宪忠.五虫通络胶囊治疗后循环缺血性眩晕临床研究[J].陕西中医,2021,42(4):452-455.
[14] 李焰生.中国后循环缺血的专家共识[J].中华内科杂志,2006,45(9):786-787.
[15] 王武庆,付 蓉,毕国荣,等.血管源性头晕/眩晕诊疗中国专家共识[J].中国神经免疫学和神经病学杂志,2020,27(4):253-260.
[16] 国家中医药管理局.中医病证诊断疗效标准[M].南京:南京大学出版社,1994:139-142.
[17] 王 宁.张怀亮教授在眩晕临床诊疗中运用瘀血致眩理论的经验探讨[D].郑州:河南中医药大学,2018.
[18] 佟佳馨.“无虚不作眩”学术思想研究溯源[J].辽宁中医药大学学报,2019,21(2):165-167.
[19] 张玉焕,张军平,朱亚萍.浅谈无瘀不作眩[J].新中医,2013,45(2):161-163.
[20] 刘 霞,李 凡,宋屿璠,等.四物汤药理及临床研究进展[J].中西医结合研究,2020,12(6):392-395.
[21] Yang TH,Xirasagar S,Cheng YF,et al.Association of cervical spondylosis with peripheral vertigo:A case-control study[J].Laryngoscope,2021,131(2):625-630.
[22] 齐海英.TCD在后循环缺血患者诊断中的应用[J].中国实用神经疾病杂志,2015,18(17):75-76.

相似文献/References:

[1]胡萌萌,马晨超,王圆圆,等.丹参川芎嗪注射液联合前列地尔对后循环缺血性眩晕患者脑血流量及内皮功能的影响*[J].陕西中医杂志,2019,(11):1534.
　HU Mengmeng,MA Chenchao,WANG Yuanyuan,et al.Effect of Danshen ligustrazine injection combined with alprostadil on cerebral blood flow and endothelial function in patients with posterior circulation ischemic vertigo[J].,2019,(10):1534.
[2]张金钗,王连成△,杨昌宽.醒脑开窍针法联合通脉养脑汤治疗椎-基底动脉供血不足性眩晕疗效观察*[J].陕西中医杂志,2020,(7):969.[doi:DOI:10.3969/j.issn.10007369.2020.07.040]
[3]钟 路,尹胡海,黄 婕,等.从热毒学说论治高血压*[J].陕西中医杂志,2020,(8):1131.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.032]
　ZHONG Lu,YIN Huhai,HUANG Jie,et al.Treatment of hypertension by heat toxicology[J].,2020,(10):1131.[doi:DOI:10.3969/j.issn.1000-7369.2020.08.032]
[4]李 冀,王托资,付 强.从“辰酉时”辨治高血压病探析[J].陕西中医杂志,2022,(3):338.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.016]
　LI Ji,WANG Tuozi,FU Qiang.Study on the theory of treating hypertension from “Chenyou Shi”[J].,2022,(10):338.[doi:DOI:10.3969/j.issn.1000-7369.2022.03.016]
[5]蒋 霞.针灸结合穴位贴敷在脑动脉供血不足型眩晕患者中的应用[J].陕西中医杂志,2022,(7):950.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.034]
　JIANG Xia.Application of acupuncture and moxibustion combined with acupoint application intervention in patients with dizziness of cerebral arterial insufficiency[J].,2022,(10):950.[doi:DOI:10.3969/j.issn.1000-7369.2022.07.034]
[6]刘川源,王 平,张德宏,等.旋提手法治疗颈椎病研究进展[J].陕西中医杂志,2023,(3):403.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.031]
　LIU Chuanyuan,WANG Ping,ZHANG Dehong,et al.Research progress on mechanism of cervical spondylosis with Xuanti Shoufa[J].,2023,(10):403.[doi:DOI:10.3969/j.issn.1000-7369.2023.03.031]
[7]王 兴,郭 珍,杨志宏.杨志宏教授运用清心宁神汤异病同治经验[J].陕西中医杂志,2023,(6):773.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.021]
　WANG Xing,GUO Zhen,YANG Zhihong.Professor Yang Zhihong used the experience of homotherapy for heteropathy with Qingxin Ningshen decoction[J].,2023,(10):773.[doi:DOI:10.3969/j.issn.1000-7369.2023.06.021]
[8]刘孟珍,潘秋旭,韦 斌.名中医方显明从少阳论治高血压病经验[J].陕西中医杂志,2023,(12):1783.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.026]
　LIU Mengzhen,PAN Qiuxu,WEI Bin.Professor Fang Xianming's clinical experience in treating hypertension from Shaoyang[J].,2023,(10):1783.[doi:DOI:10.3969/j.issn.1000-7369.2023.12.026]
[9]宋旭丹,张宪忠.五虫通络胶囊治疗后循环缺血性眩晕临床研究[J].陕西中医杂志,2021,(4):452.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.012]
　SONG Xudan,ZHANG Xianzhong.Study on posterior circulation ischemic vertigo treated with Wuchong Tongluo capsule[J].,2021,(10):452.[doi:DOI:10.3969/j.issn.1000-7369.2020.04.012]

备注/Memo

备注/Memo:
基金项目:陕西省重点研发计划项目(2020SF-275); 陕西省中医药管理局科研项目(2019-GJ-LC007); 西安市科技计划项目(2019115613YX011SF044)
更新日期/Last Update: 2021-10-09