[1]李 健,贾 瑞,王 超,等.健脾益气汤联合化疗对肺癌术后患者免疫功能的影响[J].陕西中医,2023,(4):459-462.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.011]
　LI Jian,JIA Rui,WANG Chao,et al.Effect of Jianpi Yiqi decoction combined with chemotherapy on immune function in patients with lung cancer after surgery[J].,2023,(4):459-462.[doi:DOI:10.3969/j.issn.1000-7369.2023.04.011]
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健脾益气汤联合化疗对肺癌术后患者免疫功能的影响
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《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2023年4期
页码:
459-462
栏目:
临床研究
出版日期:
2023-04-05

文章信息/Info

Title:
Effect of Jianpi Yiqi decoction combined with chemotherapy on immune function in patients with lung cancer after surgery
作者:
李 健1; 贾 瑞1; 王 超1; 丁家宝1; 高 鲲1; 刘 赫1; 丁玉龙2; 梁华刚1
(1.秦皇岛市第一医院,河北 秦皇岛 066099; 2.北京市丰台中西医结合医院,北京 100072)
Author(s):
LI Jian; JIA Rui; WANG Chao; DING Jiabao; GAO Kun; LIU He; DING Yulong; LIANG Huagang
(The First Hospital of Qinhuangdao,Qinhuangdao 066099,China)
关键词:
肺癌;  健脾益气汤;  培美曲塞;  白蛋白紫杉醇;  洛铂;  免疫功能
Keywords:
Lung cancer;  Jianpi Yiqi decoction;  Pemetrexed;  Albumin paclitaxel;  Lobaplatin;  Immune function
分类号:
R 734.2
DOI:
DOI:10.3969/j.issn.1000-7369.2023.04.011
文献标志码:
A
摘要:
目的:探究健脾益气汤联合化疗对肺癌术后患者免疫功能的影响。方法:回顾性分析106例肺癌术后患者临床资料,将采用常规化疗的患者纳入对照组(n=53),采用健脾益气汤联合化疗的患者纳入试验组(n=53)。比较两组疗效和治疗前后中医证候积分、免疫功能、生存质量及体重、不良反应。结果:两组患者均顺利完成化疗,试验组治疗总有效率高于对照组(P<0.05); 两组治疗后中医证候积分均下降,试验组低于对照组(P<0.05); 对照组治疗后CD3+、CD4+、CD4+/CD8+水平均下降,CD8+水平上升(P<0.05); 试验组CD3+、CD4+、CD4+/CD8+水平均上升,CD8+水平下降,试验组CD3+、CD4+、CD4+/CD8+、CD8+水平优于对照组(P<0.05); 治疗后,两组免疫球蛋白(Ig)A水平比较差异无统计学意义(P>0.05); 试验组IgM、IgG水平显著高于对照组(P<0.05); 两组治疗后Karnofsky体能状况(KPS)评分、体重均上升,且试验组高于对照组(P<0.05); 治疗期间两组恶心呕吐、脱发程度比较差异有统计学意义(P<0.05),肾、肝功能异常程度比较差异无统计学意义(P>0.05)。结论:健脾益气汤联合化疗可改善肺癌术后患者免疫功能,改善患者中医证候和生存质量,改善患者体重,减少化疗药物不良反应,提高疗效。
Abstract:
Objective:To explore the effect of Jianpi Yiqi decoction combined with chemotherapy on immune function in patients with lung cancer after surgery.Methods:A retrospectively was performed on the clinical data of 106 lung cancer patients who had undergone operation.Patients receiving conventional chemotherapy were included in the control group(n=53), and those receiving Jianpi Yiqi decoction combined with chemotherapy were included in the experimental group(n=53).The two groups were compared in terms of curative effect,TCM syndrome scores,immune function,quality of life,weight and adverse reactions.Results:All patients successfully completed chemotherapy.The total effective rate in the experimental group was higher than that in the control group(P<0.05).After treatment,TCM syndrome scores of the two groups decreased,and the scores of the experimental group were lower than those of the control group(P<0.05).After treatment,the levels of T lymphocyte subsets CD3+,CD4+ and CD4+/CD8+ decreased,while CD8+ level increased in the control group(P<0.05).After treatment,the levels of CD3+,CD4+ and CD4+/CD8+ increased,while CD8+ level decreased in the experimental group,the levels of CD3+,CD4+,CD4+/CD8+ and CD8+ in the experimental group were better than those in the control group(P<0.05).After treatment,there was no statistical difference in IgA level between the two groups(P>0.05).After treatment,the experimental group had higher IgM and IgG levels than the control group(P<0.05).After treatment,KPS scores and weight of the two groups increased,and those in the experimental group were higher than the control group(P<0.05).The severity of nausea,vomiting,and alopecia showed statistical difference between groups(P<0.05),but there was no statistical difference in the severity of renal and liver function abnormalities(P>0.05).Conclusion:Jianpi Yiqi decoction combined with chemotherapy can significantly improve immune function,improve TCM syndrome scores and quality of life,increase weight and reduce adverse reactions in patients with lung cancer,and improve efficacy.

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备注/Memo

备注/Memo:
基金项目:河北省秦皇岛市重点研发计划科技支撑项目(202004A103)
更新日期/Last Update: 2023-04-10