[1]严海兵,刘顺,杨秀珍.健脾益肾化浊方联合二甲双胍治疗多囊卵巢综合征合并胰岛素抵抗疗效及对患者性激素和糖脂代谢的影响[J].陕西中医,2025,46(9):1193-1197.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.008]
　YAN Haibing,LIU Shun,YANG Xiuzhen.Effects of Jianpi Yishen Huazhuo formula combined with metformin on efficacy,sex hormones,and glucose-lipid metabolism in patients with polycystic ovary syndrome complicated by insulin resistance[J].,2025,46(9):1193-1197.[doi:DOI:10.3969/j.issn.1000-7369.2025.09.008]
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健脾益肾化浊方联合二甲双胍治疗多囊卵巢综合征合并胰岛素抵抗疗效及对患者性激素和糖脂代谢的影响

《陕西中医》[ISSN:1000-7369/CN:61-1281/TN]

卷:
46
期数:
2025年9期
页码:
1193-1197
栏目:
临床研究
出版日期:
2025-09-05

文章信息/Info

Title:
Effects of Jianpi Yishen Huazhuo formula combined with metformin on efficacy,sex hormones,and glucose-lipid metabolism in patients with polycystic ovary syndrome complicated by insulin resistance
作者:
严海兵; 刘顺; 杨秀珍
（南京中医药大学附属医院 江苏省中医院，江苏 南京 211164）
Author(s):
YAN Haibing; LIU Shun; YANG Xiuzhen
(Affiliated Hospital of Nanjing University of Chinese Medicine，Jiangsu Provincial Hospital of Chinese Medicine,Nanjing 211164,China)
关键词:
多囊卵巢综合征; 胰岛素抵抗; 健脾益肾化浊方; 二甲双胍; 性激素; 糖脂代谢
Keywords:
Polycystic ovary syndrome; Insulin resistance; Jianpi Yishen Huazhuo formula; Metformin; Sex hormones; Glucose-lipid metabolism
分类号:
R 711.73
DOI:
DOI:10.3969/j.issn.1000-7369.2025.09.008
文献标志码:
A
摘要:
目的：探讨健脾益肾化浊方联合二甲双胍治疗多囊卵巢综合征（PCOS）合并胰岛素抵抗（IR）的临床疗效及对患者性激素和糖脂代谢的影响。方法：选取106例PCOS-IR患者随机分为观察组（健脾益肾化浊方+二甲双胍，n=53）和对照组（二甲双胍单药，n=53），疗程3个月经周期。评估两组治疗前后基础体温（BBT）排卵率、性激素水平[总睾酮（T）、黄体生成素（LH）、卵泡刺激素（FSH）]、糖脂代谢指标[空腹血糖（FPG）、空腹胰岛素（FINS）、HOMA-IR、血脂谱及胰岛素敏感性（葡萄糖输注率GIR、M值）]，并监测安全性。结果：治疗后，观察组BBT排卵率显著高于对照组（P<0.05）；两组性激素（T、LH）水平均显著降低（P<0.05），但组间比较无统计学差异（P>0.05）。糖脂代谢方面，观察组FINS、HOMA-IR、总胆固醇（TC）、三酰甘油（TG）改善幅度均优于对照组（均P<0.05），胰岛素敏感性指标（GIR、M值）提升更显著（P<0.001）。两组不良反应发生率比较无统计学差异（P>0.05）。结论：健脾益肾化浊方联合二甲双胍可协同改善PCOS-IR患者排卵功能及糖脂代谢紊乱，疗效优于二甲双胍单药治疗，且安全性良好。
Abstract:
Objective:To investigate the clinical efficacy of Jianpi Yishen Huazhuo formula combined with metformin in treating polycystic ovary syndrome (PCOS) complicated by insulin resistance (IR) and its effects on sex hormones and glucose-lipid metabolism.Methods:A total of 106 PCOS-IR patients were randomly divided into an observation group (Jianpi Yishen Huazhuo formula + metformin,n=53) and a control group (metformin alone,n=53) for a treatment course of three menstrual cycles.Outcomes included basal body temperature (BBT) ovulation rate,sex hormone levels [total testosterone （T）,luteinizing hormone （LH）,follicle-stimulating hormone （FSH)],glucose-lipid metabolism indicators [fasting plasma glucose (FPG),fasting insulin (FINS),HOMA-IR,lipid profiles],insulin sensitivity [glucose infusion rate (GIR),M-value],and safety monitoring.Results:After treatment,the BBT ovulation rate in the observation group was significantly higher than in the control group (P<0.05).Both groups showed significant reductions in sex hormone levels (T,LH;P<0.05),with no intergroup differences (P>0.05).In glucose-lipid metabolism,the observation group demonstrated superior improvements in FINS,HOMA-IR,total cholesterol (TC),and triglycerides (TG) compared to the control group(P<0.05).Insulin sensitivity indices (GIR,M-value) were also significantly enhanced in the observation group (P<0.001).No statistical difference in adverse reaction rates was observed between the groups (P>0.05).Conclusion:The combination of Jianpi Yishen Huazhuo formula and metformin synergistically improves ovulation function and glucose-lipid metabolism in PCOS-IR patients,with superior efficacy to metformin monotherapy and good safety.

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备注/Memo

备注/Memo:
江苏省科学技术厅基础研究计划（自然科学基金）-面上项目（BK20211395）
更新日期/Last Update: 2025-09-08