[1]裴书飞,夏永欣.康复新液联合奥美拉唑治疗Ⅱ~Ⅲ级反流性食管炎效果研究*[J].陕西中医杂志,2019,(1):61-63.
　PEI Shufei,XIA Yongxin..Effect of omeprazole combined with Kangfuxin liquid on treatment of grade II to grade III reflux esophagitis[J].,2019,(1):61-63.
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康复新液联合奥美拉唑治疗Ⅱ~Ⅲ级反流性食管炎效果研究*
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《陕西中医》杂志[ISSN:1000-7369/CN:61-1281/TN]

卷:
期数:
2019年1期
页码:
61-63
栏目:
临床研究
出版日期:
2019-01-05

文章信息/Info

Title:
Effect of omeprazole combined with Kangfuxin liquid on treatment of grade II to grade III reflux esophagitis
文章编号:
DOI:10.3969/j.issn.10007369.2019.01.019
作者:
裴书飞; 夏永欣
河南省南阳市中心医院消化内科二病区 （南阳473000）
Author(s):
PEI Shufei; XIA Yongxin.
Department of Digestive Internal Medicine, Nanyang Central Hospital in Henan Province（Nanyang 473000）
关键词:
反流性食管炎; 奥美拉唑; 康复新液; Ⅱ~Ⅲ级; 不良反应; 复发率
Keywords:
Key words Omeprazole;  Kangfuxin Liquid;  Grade Ⅱ to Ⅲ;  Reflux esophagitis; Adverse reaction; Recurrencerate
分类号:
R571
文献标志码:
A
摘要:
摘 要 目的：探讨奥美拉唑与康复新液联合治疗Ⅱ~Ⅲ级反流性食管炎的效果。方法：选择Ⅱ~Ⅲ级反流性食管炎患者122例，以随机数表法将其分为对照组与研究组，每组各61例。对照组口服奥美拉唑治疗，研究组在此基础上口服康复新液治疗。根据2002年试行的《中药新药临床研究指导原则》对比两组临床疗效，根据SavaryMiller标准对比两组内镜下疗效，对比两组治疗期间的不良反应，以及停药4周后的复发情况。结果：研究组治疗的总有效率为91.80%高于对照组77.05%（P<0.05）。研究组内镜观察下的总有效率为88.52%高于对照组73.77%（P<0.05）。两组不良反应发生率对比差异无统计学意义（P>0.05）。停药4周后随访显示，研究组的复发率13.11%低于对照组29.51%（P<0.05）。结论：奥美拉唑与康复新液联合治疗Ⅱ~Ⅲ级反流性食管炎效果显著，且降低了复发率，适于临床应用。
Abstract:
Abstract Objective: To explore the effect of omeprazole combined with Kangfuxin liquid in the treatment of reflux esophagitis of grade Ⅱ to grade Ⅲ. Methods: 122 patients with grade II ~ III reflux esophagitis were divided into a control group and a study group with 61 cases in each group. The control group was treated with omeprazole, and the study group was treated with Kangfuxin liquid. According to the clinical study guiding principles of Chinese medicine new medicine in 2002, the clinical efficacy of the two groups was compared. According to the SavaryMiller standard, the efficacy of the two groups was compared, the adverse reactions during the treatment of the two groups were compared, and the recurrence of the two groups after the withdrawal of 4W was compared. Results: The total effective rate of the study group was 91.80%, which was higher than that of the control group (77.05%) (P<0.05). The total effective rate of the study group under endoscopy was 88.52%, which was higher than that of the control group 73.77%(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). After the withdrawal of 4W, the recurrence rate in the study group was 13.11% lower than that in the control group 29.51% (P<0.05). Conclusion: Omeprazole combined with Kangfuxin Liquid is effective in treating grade Ⅱ ~ Ⅲ grade reflux esophagitis, and significantly reduces the relapse rate. 

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备注/Memo

备注/Memo:
*河南省科技厅重点科技攻关项目（0211041800）
更新日期/Last Update: 2019-03-13